A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling
Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphe...
Saved in:
| Published in | Cell research Vol. 31; no. 10; pp. 1088 - 1105 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Singapore
Springer Singapore
01.10.2021
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (
SNHG9
) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically,
SNHG9
and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of
SNHG9
suppresses xenograft breast tumor growth. Clinically, expression of
SNHG9
positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e.,
SNHG9
) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1). |
|---|---|
| AbstractList | Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (
SNHG9
) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically,
SNHG9
and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of
SNHG9
suppresses xenograft breast tumor growth. Clinically, expression of
SNHG9
positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e.,
SNHG9
) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1). Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically, expression of SNHG9 positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e., SNHG9) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1).Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically, expression of SNHG9 positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e., SNHG9) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1). Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role in signal transduction remains largely undeciphered. In this study, we uncovered a lipid-associated lncRNA, small nucleolar RNA host gene 9 (SNHG9) as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1 (LATS1) and inhibiting the Hippo pathway. Mechanistically, SNHG9 and its associated phosphatidic acids (PA) interact with the C-terminal domain of LATS1, promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation. Loss of SNHG9 suppresses xenograft breast tumor growth. Clinically, expression of SNHG9 positively correlates with YAP activity and breast cancer progression. Taken together, our results uncover a novel regulatory role of a tumor-promoting lncRNA (i.e., SNHG9) in signal transduction and cancer development by facilitating the LLPS of a signaling kinase (i.e., LATS1). |
| Author | Liu, Fang-Zhou Li, Jun-Hong Li, Xu Xiong, Yan Zhang, Zhen Wang, Liang-Jing Zhou, Tianhua Li, Rui-Hua Lin, Aifu Yan, Qingfeng Shao, Jian-Zhong Tian, Tian Ju, Huai-Qiang Wang, Wenqi Shi, Cheng-Yu Ge, Qi-Wei Liu, Ya-Zhuo Liu, Jian He, Xin-Yu Sang, Ling-Jie Yang, Zuo-Zhen |
| Author_xml | – sequence: 1 givenname: Rui-Hua surname: Li fullname: Li, Rui-Hua organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 2 givenname: Tian surname: Tian fullname: Tian, Tian organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine – sequence: 3 givenname: Qi-Wei orcidid: 0000-0003-1689-6836 surname: Ge fullname: Ge, Qi-Wei organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine and Institute of Gastroenterology, Zhejiang University – sequence: 4 givenname: Xin-Yu surname: He fullname: He, Xin-Yu organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 5 givenname: Cheng-Yu surname: Shi fullname: Shi, Cheng-Yu organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 6 givenname: Jun-Hong surname: Li fullname: Li, Jun-Hong organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 7 givenname: Zhen surname: Zhang fullname: Zhang, Zhen organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 8 givenname: Fang-Zhou surname: Liu fullname: Liu, Fang-Zhou organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 9 givenname: Ling-Jie orcidid: 0000-0003-1485-2426 surname: Sang fullname: Sang, Ling-Jie organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 10 givenname: Zuo-Zhen surname: Yang fullname: Yang, Zuo-Zhen organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 11 givenname: Ya-Zhuo surname: Liu fullname: Liu, Ya-Zhuo organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 12 givenname: Yan surname: Xiong fullname: Xiong, Yan organization: Department of Orthopedic Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University – sequence: 13 givenname: Qingfeng orcidid: 0000-0002-5381-8426 surname: Yan fullname: Yan, Qingfeng organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 14 givenname: Xu surname: Li fullname: Li, Xu organization: Key Laboratory of Structural Biology of Zhejiang Province, Westlake Laboratory of Life Sciences and Biomedicine, Westlake University – sequence: 15 givenname: Huai-Qiang orcidid: 0000-0003-1713-5465 surname: Ju fullname: Ju, Huai-Qiang organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine – sequence: 16 givenname: Jian orcidid: 0000-0002-1447-0973 surname: Liu fullname: Liu, Jian organization: Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, International Campus, Zhejiang University, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University – sequence: 17 givenname: Liang-Jing surname: Wang fullname: Wang, Liang-Jing organization: Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine and Institute of Gastroenterology, Zhejiang University – sequence: 18 givenname: Jian-Zhong orcidid: 0000-0002-7702-7098 surname: Shao fullname: Shao, Jian-Zhong organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University – sequence: 19 givenname: Wenqi orcidid: 0000-0003-4053-5088 surname: Wang fullname: Wang, Wenqi organization: Department of Developmental and Cell Biology, University of California, Irvine – sequence: 20 givenname: Tianhua surname: Zhou fullname: Zhou, Tianhua organization: Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine and Institute of Gastroenterology, Zhejiang University, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Cancer Center, Zhejiang University – sequence: 21 givenname: Aifu orcidid: 0000-0002-3968-3617 surname: Lin fullname: Lin, Aifu email: linaifu@zju.edu.cn organization: MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Cancer Center, Zhejiang University, Breast Center of the First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory for Cell and Gene Engineering of Zhejiang Province |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34267352$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Ustu1TAQjVARfcAPsECW2LAJjF-JvUG6qmiLdFUQLQtWluM4ua5y7dROkNhU_AN_yJfgS1oeXXTlkeacM2fG57DY88HboniO4TUGKt4khhkhJRBcAnAKpXxUHOCaibIWVOzlGiC3KiD7xWFKVwCEM46fFPuUkaqmnBwUNys0bkIaN3pyrTNIG9eWjfOt8z0avPl0vkIX52enEnW5NbhJTzah9eryAqPBXc-u_fn9x1JkIZ0sSnbUMasFj6aAxhi2YbIoeBN66_OEL6uPKLne6yGPeFo87vSQ7LPb96j4fPLu8visXH84fX-8WpeGM5hK0lDGa8J112DQUmpBhIQOLLOSYdM0HeOmoy3VtRG8FfkGEqoWsxo0s2DoUfF20R3nZmtbY_0U9aDG6LY6flNBO_V_x7uN6sNXJZioalllgVe3AjFczzZNauuSscOgvQ1zUoRzImshKcnQl_egV2GOed8dqhakYhwgo1786-iPlbuvyQCxAEwMKUXbKbO7fr5rNugGhUHtUqCWFKicAvU7BUpmKrlHvVN_kEQXUspg39v41_YDrF_hUMWv |
| CitedBy_id | crossref_primary_10_1016_j_cyto_2024_156585 crossref_primary_10_1073_pnas_2115369119 crossref_primary_10_1124_dmd_123_001570 crossref_primary_10_1631_jzus_B2300497 crossref_primary_10_1016_j_compbiomed_2024_107975 crossref_primary_10_3390_cancers14071830 crossref_primary_10_3389_fonc_2021_810893 crossref_primary_10_1038_s41392_024_01805_4 crossref_primary_10_3389_fimmu_2023_1265517 crossref_primary_10_1016_j_ceb_2023_102243 crossref_primary_10_1124_jpet_124_002174 crossref_primary_10_1158_0008_5472_CAN_24_1271 crossref_primary_10_1186_s12943_023_01814_x crossref_primary_10_1038_s41556_022_00911_1 crossref_primary_10_1038_s41540_024_00414_9 crossref_primary_10_1158_0008_5472_CAN_24_0067 crossref_primary_10_1186_s13046_022_02403_4 crossref_primary_10_1038_s41467_023_42341_z crossref_primary_10_1096_fj_202300216R crossref_primary_10_2139_ssrn_4066027 crossref_primary_10_1038_s41417_022_00487_w crossref_primary_10_1007_s11160_022_09734_7 crossref_primary_10_1007_s11239_023_02798_7 crossref_primary_10_3389_fgene_2022_930792 crossref_primary_10_62347_YZGC6734 crossref_primary_10_1111_boc_202400115 crossref_primary_10_1158_0008_5472_CAN_22_1289 crossref_primary_10_1016_j_ceb_2025_102476 crossref_primary_10_1096_fj_202400436R crossref_primary_10_3389_fchem_2022_834503 crossref_primary_10_1038_s41556_023_01162_4 crossref_primary_10_1073_pnas_2202133119 crossref_primary_10_1158_0008_5472_CAN_22_0717 crossref_primary_10_1631_jzus_B2200194 crossref_primary_10_1007_s11427_023_2425_2 crossref_primary_10_3390_ijms242015418 crossref_primary_10_3389_fgene_2022_834471 crossref_primary_10_1016_j_isci_2022_105275 crossref_primary_10_1038_s41467_025_56879_7 crossref_primary_10_1038_s41556_023_01309_3 crossref_primary_10_1038_s41589_023_01516_x crossref_primary_10_1016_j_tig_2023_09_001 crossref_primary_10_1080_19491034_2023_2293599 crossref_primary_10_1073_pnas_2220296120 crossref_primary_10_1016_j_canlet_2024_216614 crossref_primary_10_1002_ctm2_1300 crossref_primary_10_1038_s41419_023_05802_3 crossref_primary_10_1002_mco2_70128 crossref_primary_10_1016_j_jbior_2024_101069 crossref_primary_10_1007_s12094_022_03060_x crossref_primary_10_1007_s42764_022_00091_0 crossref_primary_10_1016_j_ijbiomac_2024_137748 crossref_primary_10_3390_ijms24021579 crossref_primary_10_1161_CIRCRESAHA_122_322113 crossref_primary_10_3390_cancers15235497 crossref_primary_10_1002_mco2_141 crossref_primary_10_1038_s41392_022_01076_x crossref_primary_10_1038_s41467_023_37871_5 crossref_primary_10_3390_ijms24032197 crossref_primary_10_3390_jdb11040045 crossref_primary_10_18632_aging_204812 crossref_primary_10_1016_j_celrep_2022_111935 crossref_primary_10_1093_nar_gkac233 crossref_primary_10_1073_pnas_2206694120 crossref_primary_10_1038_s41388_023_02910_4 crossref_primary_10_2139_ssrn_4189094 crossref_primary_10_1016_j_jare_2024_02_010 crossref_primary_10_1166_jbn_2023_3665 crossref_primary_10_1186_s13046_024_03225_2 crossref_primary_10_1002_mco2_133 crossref_primary_10_1016_j_cellsig_2023_110848 crossref_primary_10_3390_ijms242115897 crossref_primary_10_1021_acsnano_4c07783 crossref_primary_10_3390_ijms25010597 crossref_primary_10_1007_s11033_023_08548_5 crossref_primary_10_1126_science_ade0522 crossref_primary_10_5582_bst_2022_01304 crossref_primary_10_1016_j_bbcan_2024_189206 crossref_primary_10_1002_mco2_640 crossref_primary_10_1038_s41419_023_05933_7 crossref_primary_10_1007_s10565_024_09874_5 crossref_primary_10_1016_j_lfs_2024_122931 crossref_primary_10_1093_carcin_bgad080 crossref_primary_10_1038_s42255_022_00616_7 crossref_primary_10_1186_s13046_024_03109_5 crossref_primary_10_3390_cells11071149 crossref_primary_10_1007_s12032_023_02179_3 crossref_primary_10_1007_s12013_022_01067_3 crossref_primary_10_1186_s12943_025_02239_4 crossref_primary_10_1080_15548627_2024_2325304 crossref_primary_10_1186_s13578_023_01101_8 crossref_primary_10_1038_s41392_024_02070_1 crossref_primary_10_1038_s41401_024_01306_8 crossref_primary_10_3389_fimmu_2024_1485123 crossref_primary_10_1007_s11427_024_2661_3 crossref_primary_10_18632_aging_205212 crossref_primary_10_1016_j_tem_2023_10_003 |
| Cites_doi | 10.1016/j.cell.2020.09.002 10.1038/ncomms9357 10.1038/ncb3113 10.1172/JCI79573 10.1073/pnas.86.14.5351 10.1016/j.cell.2014.10.013 10.1101/gad.1909210 10.1016/j.cell.2015.10.044 10.1016/j.devcel.2010.09.011 10.1016/j.molcel.2009.01.026 10.1038/nrm.2017.7 10.1038/ncb3464 10.1074/jbc.M709037200 10.1016/j.molcel.2015.09.006 10.1126/science.aat1022 10.1016/j.ccell.2015.02.004 10.1038/ncb3295 10.1016/j.molcel.2018.08.038 10.1016/j.cell.2018.06.006 10.1038/s41556-020-0572-2 10.1038/s41586-019-1374-1 10.1016/j.molcel.2019.08.014 10.1126/science.aaf4382 10.1242/dev.045500 10.1038/ncb3473 10.1074/jbc.R114.566091 10.1038/nature22822 10.1038/s41556-019-0433-z 10.1038/nrc3458 10.1073/pnas.79.6.1683 10.1126/science.aar7432 10.1016/j.molcel.2015.08.018 10.1101/gad.274027.115 10.1016/j.molcel.2018.08.014 10.1124/pr.114.009217 10.1194/jlr.R083964 10.1016/j.semcdb.2018.07.001 10.1146/annurev-micro-090817-062814 10.15252/embj.201797609 10.1101/gad.264929.115 10.1126/science.aao0409 10.1016/j.cell.2018.11.034 10.1126/science.aar7366 10.1016/j.molcel.2015.09.017 10.1016/j.cell.2018.12.035 10.1016/j.jmb.2018.05.003 10.1073/pnas.1500851112 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS 2021 2021. The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS. The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS 2021. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS 2021 – notice: 2021. The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS. – notice: The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS 2021. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI RC3 7X8 5PM |
| DOI | 10.1038/s41422-021-00530-9 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1748-7838 |
| EndPage | 1105 |
| ExternalDocumentID | PMC8486796 34267352 10_1038_s41422_021_00530_9 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 81872300; 81672791; 82071567 funderid: https://doi.org/10.13039/501100001809 – fundername: NIGMS NIH HHS grantid: R01 GM126048 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 81872300 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 81672791 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 82071567 – fundername: ; grantid: 81872300; 81672791; 82071567 |
| GroupedDBID | --- -01 -0A -Q- -SA -S~ 0R~ 29B 2WC 36B 39C 3V. 4.4 406 53G 5GY 5VR 5XA 5XB 6J9 70F 7X7 88E 8FE 8FH 8FI 8FJ 92E 92I 92M 9D9 9DA AACDK AAHBH AANZL AASML AATNV AAXDM AAYZH AAZLF ABAKF ABAWZ ABJNI ABUWG ABZZP ACAOD ACGFO ACGFS ACIWK ACKTT ACMJI ACPRK ACRQY ACZOJ ADBBV ADFRT ADHDB AEFQL AEJRE AEMSY AENEX AESKC AEUYN AEVLU AEXYK AFBBN AFKRA AFRAH AFSHS AFUIB AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AOIJS AXYYD BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI C1A CAG CAJEA CCEZO CCPQU CCVFK CHBEP COF CS3 CW9 DIK DNIVK DPUIP DU5 E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FA0 FDQFY FERAY FIGPU FIZPM FSGXE FYUFA GX1 HCIFZ HMCUK HYE HZ~ IWAJR JSO JUIAU JZLTJ KQ8 LGEZI LK8 LOTEE M1P M7P NADUK NAO NQJWS NXXTH O9- OK1 P2P PQQKQ PROAC PSQYO Q-- Q-0 R-A RNS RNT RNTTT ROL RPM RT1 S.. SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT T8Q TAOOD TBHMF TCJ TDRGL TGP TR2 U1F U1G U5A U5K UKHRP WFFXF XSB ~88 AAYXX ABBRH ABDBE ABFSG ACMFV ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT ABRTQ CGR CUY CVF ECM EIF NPM PJZUB PPXIY PQGLB 7QO 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI PUEGO RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c540t-2b345725afb10a99a82890f0e4e941cbbf45cf3d3a7c85d8748906d1470a4e0c3 |
| IEDL.DBID | 7X7 |
| ISSN | 1001-0602 1748-7838 |
| IngestDate | Thu Aug 21 18:39:21 EDT 2025 Fri Jul 11 03:57:30 EDT 2025 Sat Aug 23 14:49:24 EDT 2025 Mon Jul 21 06:03:06 EDT 2025 Tue Jul 01 03:41:39 EDT 2025 Thu Apr 24 23:07:57 EDT 2025 Fri Feb 21 02:38:08 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | 2021. The Author(s), under exclusive licence to Center for Excellence in Molecular Cell Science, CAS. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c540t-2b345725afb10a99a82890f0e4e941cbbf45cf3d3a7c85d8748906d1470a4e0c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-1713-5465 0000-0002-3968-3617 0000-0003-1485-2426 0000-0003-1689-6836 0000-0002-7702-7098 0000-0003-4053-5088 0000-0002-5381-8426 0000-0002-1447-0973 |
| OpenAccessLink | https://www.nature.com/articles/s41422-021-00530-9.pdf |
| PMID | 34267352 |
| PQID | 2578264500 |
| PQPubID | 536307 |
| PageCount | 18 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8486796 proquest_miscellaneous_2552978932 proquest_journals_2578264500 pubmed_primary_34267352 crossref_citationtrail_10_1038_s41422_021_00530_9 crossref_primary_10_1038_s41422_021_00530_9 springer_journals_10_1038_s41422_021_00530_9 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-01 |
| PublicationDateYYYYMMDD | 2021-10-01 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Singapore |
| PublicationPlace_xml | – name: Singapore – name: England – name: London |
| PublicationTitle | Cell research |
| PublicationTitleAbbrev | Cell Res |
| PublicationTitleAlternate | Cell Res |
| PublicationYear | 2021 |
| Publisher | Springer Singapore Nature Publishing Group |
| Publisher_xml | – name: Springer Singapore – name: Nature Publishing Group |
| References | Hahn (CR8) 2018; 175 Cai (CR17) 2019; 21 Lin (CR3) 2017; 19 Du, Chen (CR9) 2018; 361 Halder, Johnson (CR23) 2011; 138 Clemson (CR11) 2009; 33 Meng, Moroishi, Guan (CR44) 2016; 30 Zhao, Li, Lei, Guan (CR25) 2010; 24 Fay, Anderson (CR36) 2018; 430 Langdon, Gladfelter (CR41) 2018; 72 Pan (CR24) 2010; 19 Larson (CR15) 2017; 547 Bruntz, Lindsley, Brown (CR22) 2014; 66 Harvey, Zhang, Thomas (CR27) 2013; 13 Sawyer, Bartek, Dundr (CR16) 2019; 90 Egea-Jimenez, Zimmermann (CR19) 2018; 59 Micsonai (CR46) 2015; 112 Meng (CR32) 2015; 6 Ries (CR7) 2019; 571 Zhu (CR18) 2020; 183 Shin, Brangwynne (CR35) 2017; 357 Yu, Zhao, Guan (CR28) 2015; 163 Lin, Protter, Rosen, Parker (CR33) 2015; 60 Wang (CR34) 2018; 174 Burke, Janke, Rhine, Fawzi (CR40) 2015; 60 Ni, Zheng, Hara, Pan, Luo (CR29) 2015; 29 Li (CR30) 2017; 19 Wang, Xu, Wang, Cao (CR31) 2017; 358 Hauser, Gains (CR42) 1982; 79 Langdon (CR13) 2018; 360 Alberti, Gladfelter, Mittag (CR10) 2019; 176 Liu (CR6) 2015; 27 Foster, Salloum, Menon, Frias (CR20) 2014; 289 Daneshvar (CR37) 2020; 22 Zhang (CR39) 2015; 60 Maharana (CR12) 2018; 360 Wang (CR47) 2015; 17 Sang, Ju (CR5) 2018; 72 Lin (CR2) 2016; 18 Han (CR21) 2018; 72 Zhou (CR26) 2015; 125 Hauser (CR43) 1989; 86 Hao, Chun, Cheung, Rashidi, Yang (CR45) 2008; 283 Zheng (CR4) 2017; 36 Yao (CR14) 2019; 76 Xing (CR1) 2014; 159 Banani, Lee, Hyman, Rosen (CR38) 2017; 18 Y Lin (530_CR33) 2015; 60 H Hauser (530_CR43) 1989; 86 Y Hao (530_CR45) 2008; 283 X Zhou (530_CR26) 2015; 125 K Daneshvar (530_CR37) 2020; 22 A Lin (530_CR3) 2017; 19 RC Bruntz (530_CR22) 2014; 66 Z Meng (530_CR32) 2015; 6 Z Meng (530_CR44) 2016; 30 IA Sawyer (530_CR16) 2019; 90 B Zhao (530_CR25) 2010; 24 W Wang (530_CR47) 2015; 17 AL Egea-Jimenez (530_CR19) 2018; 59 DA Foster (530_CR20) 2014; 289 B Liu (530_CR6) 2015; 27 C Li (530_CR30) 2017; 19 EM Langdon (530_CR13) 2018; 360 A Lin (530_CR2) 2016; 18 KA Burke (530_CR40) 2015; 60 D Pan (530_CR24) 2010; 19 S Alberti (530_CR10) 2019; 176 RW Yao (530_CR14) 2019; 76 KF Harvey (530_CR27) 2013; 13 X Zheng (530_CR4) 2017; 36 RJ Ries (530_CR7) 2019; 571 S Hahn (530_CR8) 2018; 175 H Hauser (530_CR42) 1982; 79 AG Larson (530_CR15) 2017; 547 J Wang (530_CR34) 2018; 174 MM Fay (530_CR36) 2018; 430 Y Shin (530_CR35) 2017; 357 P Wang (530_CR31) 2017; 358 G Zhu (530_CR18) 2020; 183 H Zhang (530_CR39) 2015; 60 H Han (530_CR21) 2018; 72 A Micsonai (530_CR46) 2015; 112 FX Yu (530_CR28) 2015; 163 L Ni (530_CR29) 2015; 29 D Cai (530_CR17) 2019; 21 SF Banani (530_CR38) 2017; 18 M Du (530_CR9) 2018; 361 G Halder (530_CR23) 2011; 138 Z Xing (530_CR1) 2014; 159 EM Langdon (530_CR41) 2018; 72 L-J Sang (530_CR5) 2018; 72 S Maharana (530_CR12) 2018; 360 CM Clemson (530_CR11) 2009; 33 |
| References_xml | – volume: 183 start-page: 1 year: 2020 end-page: 13 ident: CR18 article-title: Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation publication-title: Cell. doi: 10.1016/j.cell.2020.09.002 – volume: 6 year: 2015 ident: CR32 article-title: MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway publication-title: Nat Commun. doi: 10.1038/ncomms9357 – volume: 17 start-page: 490 year: 2015 end-page: 499 ident: CR47 article-title: AMPK modulates Hippo pathway activity to regulate energy homeostasis publication-title: Nat Cell Biol. doi: 10.1038/ncb3113 – volume: 125 start-page: 2123 year: 2015 end-page: 2135 ident: CR26 article-title: Estrogen regulates Hippo signaling via GPER in breast cancer publication-title: J Clin Invest. doi: 10.1172/JCI79573 – volume: 86 start-page: 5351 year: 1989 end-page: 5355 ident: CR43 article-title: Mechanism of spontaneous vesiculation publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.86.14.5351 – volume: 159 start-page: 1110 year: 2014 end-page: 1125 ident: CR1 article-title: lncRNA directs cooperative epigenetic regulation downstream of chemokine signals publication-title: Cell. doi: 10.1016/j.cell.2014.10.013 – volume: 24 start-page: 862 year: 2010 end-page: 874 ident: CR25 article-title: The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version publication-title: Genes Dev. doi: 10.1101/gad.1909210 – volume: 163 start-page: 811 year: 2015 end-page: 828 ident: CR28 article-title: Hippo pathway in organ size control, tissue homeostasis, and cancer publication-title: Cell. doi: 10.1016/j.cell.2015.10.044 – volume: 19 start-page: 491 year: 2010 end-page: 505 ident: CR24 article-title: The hippo signaling pathway in development and cancer publication-title: Dev Cell. doi: 10.1016/j.devcel.2010.09.011 – volume: 33 start-page: 717 year: 2009 end-page: 726 ident: CR11 article-title: An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles publication-title: Mol Cell. doi: 10.1016/j.molcel.2009.01.026 – volume: 18 start-page: 285 year: 2017 end-page: 298 ident: CR38 article-title: Biomolecular condensates: organizers of cellular biochemistry publication-title: Nat Rev Mol Cell Biol. doi: 10.1038/nrm.2017.7 – volume: 19 start-page: 106 year: 2017 end-page: 119 ident: CR30 article-title: A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis publication-title: Nat Cell Biol. doi: 10.1038/ncb3464 – volume: 283 start-page: 5496 year: 2008 end-page: 5509 ident: CR45 article-title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP publication-title: J Biol Chem. doi: 10.1074/jbc.M709037200 – volume: 60 start-page: 231 year: 2015 end-page: 241 ident: CR40 article-title: Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.09.006 – volume: 361 start-page: 704 year: 2018 end-page: 709 ident: CR9 article-title: DNA-induced liquid phase condensation of cGAS activates innateimmune signaling publication-title: Science. doi: 10.1126/science.aat1022 – volume: 27 start-page: 370 year: 2015 end-page: 381 ident: CR6 article-title: A cytoplasmic NF-kappaB interacting long noncoding RNA blocks IkappaB phosphorylation and suppresses breast cancer metastasis publication-title: Cancer Cell. doi: 10.1016/j.ccell.2015.02.004 – volume: 18 start-page: 213 year: 2016 end-page: 224 ident: CR2 article-title: The LINK-A lncRNA activates normoxic HIF1alpha signalling in triple-negative breast cancer publication-title: Nat Cell Biol. doi: 10.1038/ncb3295 – volume: 72 start-page: 328 year: 2018 end-page: 40.e328 ident: CR21 article-title: Regulation of the hippo pathway by phosphatidic acid-mediated lipid-protein interaction publication-title: Mol Cell. doi: 10.1016/j.molcel.2018.08.038 – volume: 174 start-page: 688 year: 2018 end-page: 99.e616 ident: CR34 article-title: A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins publication-title: Cell. doi: 10.1016/j.cell.2018.06.006 – volume: 22 start-page: 1211 year: 2020 end-page: 1222 ident: CR37 article-title: lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation publication-title: Nat Cell Biol. doi: 10.1038/s41556-020-0572-2 – volume: 571 start-page: 424 year: 2019 end-page: 428 ident: CR7 article-title: m(6)A enhances the phase separation potential of mRNA publication-title: Nature. doi: 10.1038/s41586-019-1374-1 – volume: 76 start-page: 767 year: 2019 end-page: 83.e711 ident: CR14 article-title: Nascent Pre-rRNA Sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus publication-title: Mol Cell. doi: 10.1016/j.molcel.2019.08.014 – volume: 357 start-page: eaaf4382 year: 2017 ident: CR35 article-title: Liquid phase condensation in cell physiology and disease publication-title: Science. doi: 10.1126/science.aaf4382 – volume: 138 start-page: 9 year: 2011 end-page: 22 ident: CR23 article-title: Hippo signaling: growth control and beyond publication-title: Development. doi: 10.1242/dev.045500 – volume: 19 start-page: 238 year: 2017 end-page: 251 ident: CR3 article-title: The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors publication-title: Nat Cell Biol. doi: 10.1038/ncb3473 – volume: 289 start-page: 22583 year: 2014 end-page: 22588 ident: CR20 article-title: Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR) publication-title: J Biol Chem. doi: 10.1074/jbc.R114.566091 – volume: 547 start-page: 236 year: 2017 end-page: 240 ident: CR15 article-title: Liquid droplet formation by HP1alpha suggests a role for phase separation in heterochromatin publication-title: Nature. doi: 10.1038/nature22822 – volume: 21 start-page: 1578 year: 2019 end-page: 1589 ident: CR17 article-title: Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression publication-title: Nat Cell Biol. doi: 10.1038/s41556-019-0433-z – volume: 13 start-page: 246 year: 2013 end-page: 257 ident: CR27 article-title: The Hippo pathway and human cancer publication-title: Nat Rev Cancer. doi: 10.1038/nrc3458 – volume: 79 start-page: 1683 year: 1982 end-page: 1687 ident: CR42 article-title: Spontaneous vesiculation of phospholipids: a simple and quick method of forming unilamellar vesicles publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.79.6.1683 – volume: 360 start-page: 922 year: 2018 end-page: 927 ident: CR13 article-title: mRNA structure determines specificity of a polyQ-driven phase separation publication-title: Science. doi: 10.1126/science.aar7432 – volume: 60 start-page: 208 year: 2015 end-page: 219 ident: CR33 article-title: Formation and maturation of phase-separated liquid droplets by RNA-binding proteins publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.08.018 – volume: 30 start-page: 1 year: 2016 end-page: 17 ident: CR44 article-title: Mechanisms of Hippo pathway regulation publication-title: Genes Dev. doi: 10.1101/gad.274027.115 – volume: 72 start-page: 71 year: 2018 end-page: 83.e77 ident: CR5 article-title: LncRNA CamK-A regulates Ca -signaling-mediated tumor microenvironment remodeling publication-title: Mol Cell doi: 10.1016/j.molcel.2018.08.014 – volume: 66 start-page: 1033 year: 2014 end-page: 1079 ident: CR22 article-title: Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer publication-title: Pharmacol Rev. doi: 10.1124/pr.114.009217 – volume: 59 start-page: 1554 year: 2018 end-page: 1560 ident: CR19 article-title: Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles publication-title: J Lipid Res. doi: 10.1194/jlr.R083964 – volume: 90 start-page: 94 year: 2019 end-page: 103 ident: CR16 article-title: Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing publication-title: Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2018.07.001 – volume: 72 start-page: 255 year: 2018 end-page: 271 ident: CR41 article-title: A new lens for RNA localization: liquid-liquid phase separation publication-title: Annu Rev Microbiol. doi: 10.1146/annurev-micro-090817-062814 – volume: 36 start-page: 3325 year: 2017 end-page: 3335 ident: CR4 article-title: LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism publication-title: EMBO J. doi: 10.15252/embj.201797609 – volume: 29 start-page: 1416 year: 2015 end-page: 1431 ident: CR29 article-title: Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling publication-title: Genes Dev. doi: 10.1101/gad.264929.115 – volume: 358 start-page: 1051 year: 2017 end-page: 1055 ident: CR31 article-title: An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism publication-title: Science. doi: 10.1126/science.aao0409 – volume: 175 start-page: 1723 year: 2018 end-page: 1725 ident: CR8 article-title: Phase separation, protein disorder, and enhancer function publication-title: Cell. doi: 10.1016/j.cell.2018.11.034 – volume: 360 start-page: 918 year: 2018 end-page: 921 ident: CR12 article-title: Share RNA buffers the phase separation behavior of prion-like RNA binding proteins publication-title: Science. doi: 10.1126/science.aar7366 – volume: 60 start-page: 220 year: 2015 end-page: 230 ident: CR39 article-title: RNA controls PolyQ protein phase transitions publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.09.017 – volume: 176 start-page: 419 year: 2019 end-page: 434 ident: CR10 article-title: Considerations and challenges in studying liquid-liquid phase separation and biomolecular condensates publication-title: Cell. doi: 10.1016/j.cell.2018.12.035 – volume: 430 start-page: 4685 year: 2018 end-page: 4701 ident: CR36 article-title: The role of RNA in biological phase separations publication-title: J Mol Biol. doi: 10.1016/j.jmb.2018.05.003 – volume: 112 start-page: E3095 year: 2015 end-page: E3103 ident: CR46 article-title: Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy publication-title: Proc Natl Acad Sci. doi: 10.1073/pnas.1500851112 – volume: 66 start-page: 1033 year: 2014 ident: 530_CR22 publication-title: Pharmacol Rev. doi: 10.1124/pr.114.009217 – volume: 125 start-page: 2123 year: 2015 ident: 530_CR26 publication-title: J Clin Invest. doi: 10.1172/JCI79573 – volume: 6 year: 2015 ident: 530_CR32 publication-title: Nat Commun. doi: 10.1038/ncomms9357 – volume: 357 start-page: eaaf4382 year: 2017 ident: 530_CR35 publication-title: Science. doi: 10.1126/science.aaf4382 – volume: 19 start-page: 491 year: 2010 ident: 530_CR24 publication-title: Dev Cell. doi: 10.1016/j.devcel.2010.09.011 – volume: 90 start-page: 94 year: 2019 ident: 530_CR16 publication-title: Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2018.07.001 – volume: 289 start-page: 22583 year: 2014 ident: 530_CR20 publication-title: J Biol Chem. doi: 10.1074/jbc.R114.566091 – volume: 360 start-page: 922 year: 2018 ident: 530_CR13 publication-title: Science. doi: 10.1126/science.aar7432 – volume: 19 start-page: 106 year: 2017 ident: 530_CR30 publication-title: Nat Cell Biol. doi: 10.1038/ncb3464 – volume: 30 start-page: 1 year: 2016 ident: 530_CR44 publication-title: Genes Dev. doi: 10.1101/gad.274027.115 – volume: 86 start-page: 5351 year: 1989 ident: 530_CR43 publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.86.14.5351 – volume: 21 start-page: 1578 year: 2019 ident: 530_CR17 publication-title: Nat Cell Biol. doi: 10.1038/s41556-019-0433-z – volume: 76 start-page: 767 year: 2019 ident: 530_CR14 publication-title: Mol Cell. doi: 10.1016/j.molcel.2019.08.014 – volume: 72 start-page: 328 year: 2018 ident: 530_CR21 publication-title: Mol Cell. doi: 10.1016/j.molcel.2018.08.038 – volume: 430 start-page: 4685 year: 2018 ident: 530_CR36 publication-title: J Mol Biol. doi: 10.1016/j.jmb.2018.05.003 – volume: 36 start-page: 3325 year: 2017 ident: 530_CR4 publication-title: EMBO J. doi: 10.15252/embj.201797609 – volume: 22 start-page: 1211 year: 2020 ident: 530_CR37 publication-title: Nat Cell Biol. doi: 10.1038/s41556-020-0572-2 – volume: 360 start-page: 918 year: 2018 ident: 530_CR12 publication-title: Science. doi: 10.1126/science.aar7366 – volume: 60 start-page: 220 year: 2015 ident: 530_CR39 publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.09.017 – volume: 138 start-page: 9 year: 2011 ident: 530_CR23 publication-title: Development. doi: 10.1242/dev.045500 – volume: 29 start-page: 1416 year: 2015 ident: 530_CR29 publication-title: Genes Dev. doi: 10.1101/gad.264929.115 – volume: 159 start-page: 1110 year: 2014 ident: 530_CR1 publication-title: Cell. doi: 10.1016/j.cell.2014.10.013 – volume: 571 start-page: 424 year: 2019 ident: 530_CR7 publication-title: Nature. doi: 10.1038/s41586-019-1374-1 – volume: 60 start-page: 208 year: 2015 ident: 530_CR33 publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.08.018 – volume: 176 start-page: 419 year: 2019 ident: 530_CR10 publication-title: Cell. doi: 10.1016/j.cell.2018.12.035 – volume: 175 start-page: 1723 year: 2018 ident: 530_CR8 publication-title: Cell. doi: 10.1016/j.cell.2018.11.034 – volume: 112 start-page: E3095 year: 2015 ident: 530_CR46 publication-title: Proc Natl Acad Sci. doi: 10.1073/pnas.1500851112 – volume: 183 start-page: 1 year: 2020 ident: 530_CR18 publication-title: Cell. doi: 10.1016/j.cell.2020.09.002 – volume: 17 start-page: 490 year: 2015 ident: 530_CR47 publication-title: Nat Cell Biol. doi: 10.1038/ncb3113 – volume: 27 start-page: 370 year: 2015 ident: 530_CR6 publication-title: Cancer Cell. doi: 10.1016/j.ccell.2015.02.004 – volume: 19 start-page: 238 year: 2017 ident: 530_CR3 publication-title: Nat Cell Biol. doi: 10.1038/ncb3473 – volume: 59 start-page: 1554 year: 2018 ident: 530_CR19 publication-title: J Lipid Res. doi: 10.1194/jlr.R083964 – volume: 18 start-page: 285 year: 2017 ident: 530_CR38 publication-title: Nat Rev Mol Cell Biol. doi: 10.1038/nrm.2017.7 – volume: 547 start-page: 236 year: 2017 ident: 530_CR15 publication-title: Nature. doi: 10.1038/nature22822 – volume: 174 start-page: 688 year: 2018 ident: 530_CR34 publication-title: Cell. doi: 10.1016/j.cell.2018.06.006 – volume: 13 start-page: 246 year: 2013 ident: 530_CR27 publication-title: Nat Rev Cancer. doi: 10.1038/nrc3458 – volume: 163 start-page: 811 year: 2015 ident: 530_CR28 publication-title: Cell. doi: 10.1016/j.cell.2015.10.044 – volume: 72 start-page: 255 year: 2018 ident: 530_CR41 publication-title: Annu Rev Microbiol. doi: 10.1146/annurev-micro-090817-062814 – volume: 72 start-page: 71 year: 2018 ident: 530_CR5 publication-title: Mol Cell doi: 10.1016/j.molcel.2018.08.014 – volume: 60 start-page: 231 year: 2015 ident: 530_CR40 publication-title: Mol Cell. doi: 10.1016/j.molcel.2015.09.006 – volume: 33 start-page: 717 year: 2009 ident: 530_CR11 publication-title: Mol Cell. doi: 10.1016/j.molcel.2009.01.026 – volume: 79 start-page: 1683 year: 1982 ident: 530_CR42 publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.79.6.1683 – volume: 361 start-page: 704 year: 2018 ident: 530_CR9 publication-title: Science. doi: 10.1126/science.aat1022 – volume: 358 start-page: 1051 year: 2017 ident: 530_CR31 publication-title: Science. doi: 10.1126/science.aao0409 – volume: 18 start-page: 213 year: 2016 ident: 530_CR2 publication-title: Nat Cell Biol. doi: 10.1038/ncb3295 – volume: 283 start-page: 5496 year: 2008 ident: 530_CR45 publication-title: J Biol Chem. doi: 10.1074/jbc.M709037200 – volume: 24 start-page: 862 year: 2010 ident: 530_CR25 publication-title: Genes Dev. doi: 10.1101/gad.1909210 |
| SSID | ssj0025451 |
| Score | 2.6200168 |
| Snippet | Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1088 |
| SubjectTerms | 13/1 13/109 13/51 13/89 13/95 14/19 14/32 14/35 631/67/1347 631/80/86 64/60 82/51 82/80 82/83 Biological activity Biological Phenomena Biomedical and Life Sciences Breast cancer Cancer Cell Biology Cell Line, Tumor Cell Proliferation Hippo Signaling Pathway Homeostasis Humans Kinases Life Sciences Lipids Liquid phases Nucleoli Phase separation Phosphatidic acid Phosphatidic Acids Phosphoproteins - genetics Phosphorylation Protein Serine-Threonine Kinases - genetics RNA, Long Noncoding - genetics Signal processing Signal Transduction Signaling snoRNA Tumor suppressor genes Tumors Xenografts Xenotransplantation YAP-Signaling Proteins Yes-associated protein |
| Title | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling |
| URI | https://link.springer.com/article/10.1038/s41422-021-00530-9 https://www.ncbi.nlm.nih.gov/pubmed/34267352 https://www.proquest.com/docview/2578264500 https://www.proquest.com/docview/2552978932 https://pubmed.ncbi.nlm.nih.gov/PMC8486796 |
| Volume | 31 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFRIXxJuUUhmJG1h1YjuPEwqoZYVgVfUhLafIsR1tpFWSkt0DF8R_4B_yS5hxsrtaKnqLZCeOPWPPN_b4G0LeWOWU1lXKEiFjJsFDYTpThoWhBgDrQhH6bA1fp_HkSn6eqdm44daPYZXrNdEv1LY1uEd-jKoFxltx_r67Zpg1Ck9XxxQad8k-UpehViezrcMF6MA7XD5sKMZInoPhmnl63Evc_GAYoIB6yFm2a5huoM2bQZP_nJx6g3T6kDwYkSTNB9E_Indc85jcG3JL_nhCfua0m7d9N4eht7Wh2tQW3WC0VXTRmPNpTi-mk08ZraDIU3W7nn7JLy9CuqivV7X98-v38AAfAltHezfwhLcNXba083F8jraNaUEJoYVv-RnFcBCNN9yfkqvTk8uPEzYmW2AGQNuSRaWQKomUrsqQ6yzT6IrxijvpMhmasqykMpWwQicmVTZF1hoe21AmXEvHjXhG9pq2cS8INSKNnQy5tYBVokSVcZxWqQNX2ForuAxIuB7pwoxM5JgQY1H4E3GRFoN0CpBO4aVTZAF5u3mnG3g4bq19uBZgMc7JvthqUEBeb4phNuERiW5cu8I6KgK_GkBtQJ4P8t40JwDMJIBXA5LsaMKmAjJ175Y09dwzdqcDr2FA3q11Zvtb_-_Fwe29eEnuR6i_PrLwkOwtv6_cK0BIy_LIT4Mjsv_hZHp2_hfbIw12 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwEB6VIgQXxD8pBYwEJ4jqJHZ-DghFQNnS7QrRrbScgmM72kirJCW7Qr0g3oH34KF4EsbOZldLRW-9RbLzO5893xePZwCeK665EEXsRgELXYYKxRUJl67nCSSw2gs8W63haBQOTtjHCZ9swe9-L4wJq-znRDtRq1qaf-R7BlrovDmlb5pT11SNMqurfQmNDhaH-uw7Srb29cE7tO8L399_P347cJdVBVyJ7GTu-nnAeORzUeQeFUkijOagBdVMJ8yTeV4wLotABSKSMVexSc9CQ-WxiAqmqQzwulfgKjpeasReNFkLPGQjVuDZMKXQRA7tdNva472WmZ8trgmIMLinbrLpCM-x2_NBmv-s1FoHuH8Lbi6ZK0k7qN2GLV3dgWtdLcuzu_AjJc20bpspmlqVkghZKiO7jW8ks0p-HqXkeDT4kJACm2xqcN2SYTo-9sisPF2U6s_PX90BXgh9K2l1l5e8rsi8Jo2NG9SkrmSNoMc7fEk_ERN-IsyO-ntwcilmuA_bVV3ph0BkEIeaeVQp5EZ-xPMwjItYo_RWSgWUOeD1XzqTy8znpgDHLLMr8EGcddbJ0DqZtU6WOPBydU7T5f24sPdub8BsOQe02RqxDjxbNePoNUsyotL1wvThPup4JNEOPOjsvbpdgOQpQn7sQLSBhFUHkxl8s6UqpzZDeNzlUXTgVY-Z9WP9_y12Ln6Lp3B9MD4aZsOD0eEjuOEbLNuoxl3Ynn9b6MfIzub5EzskCHy97DH4F9G2SBU |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtNAEB6VVCAuFf-4FFgkOIGVtb3rnwNCgTaktERRf6T2ZNa7ayVSZKd1ItQL4h14Gx6HJ2F2bacKFb31Fmk3dpyZ2fk-77czAK8V11yIPHajgIUuQ4biioRL1_MEAljtBZ7t1vB1GA6O2ZcTfrIGv9uzMEZW2a6JdqFWpTTvyLvGtTB5c0q7eSOLGG33P8zOXNNByuy0tu00ahfZ0xffkb5V73e30dZvfL-_c_Rp4DYdBlyJSGXu-lnAeORzkWceFUkiDP-gOdVMJ8yTWZYzLvNABSKSMVexKdVCQ-WxiAqmqQzwurdgPTKsqAPrH3eGo4Ml3UNsYumeFS2FRke0WR9yj7sVM69eXCOPMFFA3WQ1LV7Bulclm__s29p02L8HGw2OJb3a8e7Dmi4ewO26s-XFQ_jRI7NxWc3GaHg1kUTIiTIk3GRKMi3kwbBHDoeDzwnJccgWCtcV2e8dHXpkOjlbTNSfn7_qD3ghzLSk0nWV8rIg85LMrIpQk7KQJYYA3uG0NyJGjCLM-fpHcHwjhngMnaIs9FMgMohDzTyqFCIlP-JZGMZ5rJGIK6UCyhzw2n86lU0ddNOOY5ra_fggTmvrpGid1FonTRx4u_zOrK4Ccu3srdaAabMiVOml_zrwajmMsWw2aEShy4WZw31k9QipHXhS23t5uwChVIRo2YFoxROWE0yd8NWRYjK29cLjuqqiA-9an7n8Wf9_is3rn-Il3MH4S_d3h3vP4K5vXNlKHLegMz9f6OcI1ebZiyYmCHy76TD8C-lmTbA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+phosphatidic+acid-binding+lncRNA+SNHG9+facilitates+LATS1+liquid%E2%80%93liquid+phase+separation+to+promote+oncogenic+YAP+signaling&rft.jtitle=Cell+research&rft.au=Li%2C+Rui-Hua&rft.au=Tian%2C+Tian&rft.au=Ge%2C+Qi-Wei&rft.au=He%2C+Xin-Yu&rft.date=2021-10-01&rft.issn=1001-0602&rft.eissn=1748-7838&rft.volume=31&rft.issue=10&rft.spage=1088&rft.epage=1105&rft_id=info:doi/10.1038%2Fs41422-021-00530-9&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41422_021_00530_9 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1001-0602&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1001-0602&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1001-0602&client=summon |