Associations between Brain Alpha-Tocopherol Stereoisomer Profile and Hallmarks of Brain Aging in Centenarians

• Published in: Antioxidants Vol. 13; no. 8; p. 997
• Main Authors: Chan, Jia Pei, Tanprasertsuk, Jirayu, Johnson, Elizabeth J., Dey, Priyankar, Bruno, Richard S., Johnson, Mary Ann, Poon, Leonard W., Davey, Adam, Woodard, John L., Kuchan, Matthew J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.08.2024; MDPI
• Subjects: Adults; Aging; Alpha tocopherol; Amputation; Amygdala; Amyloid; Analysis; Body mass index; Brain; Brain research; Centenarians; Cognition; Cognition & reasoning; Cognitive ability; cortex; Cortex (frontal); Dietary supplements; Food fortification; frontal lobe; Georgia; Geriatrics; neurofibrillary tangle; Older people; Oldest old people; Physiological aspects; Review boards; Senile plaques; Stereoisomers; Temporal lobe; tocopherol; Vitamin E; United States; United States > US; Georgia; older adult; cognition; centenarian; neurofibrillary tangle; vitamin E; tocopherol; aging; amyloid plaque; brain

Brain alpha-tocopherol (αT) concentration was previously reported to be inversely associated with neurofibrillary tangle (NFT) counts in specific brain structures from centenarians. However, the contribution of natural or synthetic αT stereoisomers to this relationship is unknown. In this study, αT...