Tau in the Pathophysiology of Parkinson’s Disease

• Published in: Journal of molecular neuroscience Vol. 71; no. 11; pp. 2179 - 2191
• Main Authors: Pan, Lina, Meng, Lanxia, He, Mingyang, Zhang, Zhentao
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2021; Springer Nature B.V
• Subjects: Alzheimer's disease; Animals; Autopsies; Autopsy; Biomedical and Life Sciences; Biomedicine; Cell Biology; Dopamine receptors; Genome-wide association studies; Genomes; Humans; Lewy bodies; Movement disorders; Neurochemistry; Neurodegenerative diseases; Neurology; Neurons; Neurosciences; Paralysis; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Pathophysiology; Progressive supranuclear palsy; Proteomics; Structure-function relationships; Substantia nigra; Synuclein; Tau protein; tau Proteins - chemistry; tau Proteins - genetics; tau Proteins - metabolism; α-Synuclein; Tau; Pathophysiology; Parkinson’s disease

The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs) in remaining neurons. LBs primarily consist of aggregated α-Synuclein (α-Syn). However, accumulating evidence suggests that Tau,...