Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice

• Published in: Scientific reports Vol. 8; no. 1; pp. 6554 - 15
• Main Authors: Darzi, S., Deane, J. A., Nold, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K. S., Vashi, A. V., Werkmeister, J. A., Gargett, C. E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.04.2018; Nature Publishing Group
• Subjects: 13; 13/100; 13/106; 13/107; 13/109; 13/21; 13/31; 14/19; 38/77; 631/250/2504; 631/532/2074; 64/60; 692/308/2171; CCR7 protein; Cytokines; Endometrium; Gelatin; Gene expression; Humanities and Social Sciences; Immune status; Immune system; Immunocompetence; Immunomodulation; Inflammation; Interleukin 1; Interleukin 10; Macrophages; Mesenchyme; mRNA; multidisciplinary; Paracrine signalling; Pelvic organ prolapse; Polyamides; Science; Science (multidisciplinary); Skin; Stem cell transplantation; Stem cells; Stromal cells; Tissue engineering; Tumor necrosis factor-TNF; Wound healing

The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism...