Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice

The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 8; no. 1; pp. 6554 - 15
Main Authors Darzi, S., Deane, J. A., Nold, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K. S., Vashi, A. V., Werkmeister, J. A., Gargett, C. E.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.04.2018
Nature Publishing Group
Subjects
13
13/100
13/106
13/107
13/109
13/21
13/31
14/19
38/77
631/250/2504
631/532/2074
64/60
692/308/2171
CCR7 protein
Cytokines
Endometrium
Gelatin
Gene expression
Humanities and Social Sciences
Immune status
Immune system
Immunocompetence
Immunomodulation
Inflammation
Interleukin 1
Interleukin 10
Macrophages
Mesenchyme
mRNA
multidisciplinary
Paracrine signalling
Pelvic organ prolapse
Polyamides
Science
Science (multidisciplinary)
Skin
Stem cell transplantation
Stem cells
Stromal cells
Tissue engineering
Tumor necrosis factor-TNF
Wound healing
Online AccessGet full text

Cover

Abstract The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In this study, we investigated the immunomodulatory effect of eMSC on the macrophage response to polyamide/gelatin composite mesh in an abdominal subcutaneous wound repair model in C57BL6 immunocompetent and NSG (NOD-Scid-IL2Rgamma null ) immunocompromised mice to determine whether responses differed in the absence of an adaptive immune system and NK cells. mCherry lentivirus-labelled eMSC persisted longer in NSG mice, inducing longer term paracrine effects. Inclusion of eMSC in the mesh reduced inflammatory cytokine (Il-1β, Tnfα) secretion, and in C57BL6 mice reduced CCR7 + M1 macrophages surrounding the mesh on day 3 and increased M2 macrophage marker mRNA ( Arg1 , Mrc1, Il10 ) expression at days 3 and 7. In NSG mice, these effects were delayed and only observed at days 7 and 30 in comparison with controls implanted with mesh alone. These results show that the differences in the immune status in the two animals directly affect the survival of xenogeneic eMSC which leads to differences in the short-term and long-term macrophage responses to implanted meshes.
AbstractList The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In this study, we investigated the immunomodulatory effect of eMSC on the macrophage response to polyamide/gelatin composite mesh in an abdominal subcutaneous wound repair model in C57BL6 immunocompetent and NSG (NOD-Scid-IL2Rgammanull) immunocompromised mice to determine whether responses differed in the absence of an adaptive immune system and NK cells. mCherry lentivirus-labelled eMSC persisted longer in NSG mice, inducing longer term paracrine effects. Inclusion of eMSC in the mesh reduced inflammatory cytokine (Il-1β, Tnfα) secretion, and in C57BL6 mice reduced CCR7+ M1 macrophages surrounding the mesh on day 3 and increased M2 macrophage marker mRNA (Arg1, Mrc1, Il10) expression at days 3 and 7. In NSG mice, these effects were delayed and only observed at days 7 and 30 in comparison with controls implanted with mesh alone. These results show that the differences in the immune status in the two animals directly affect the survival of xenogeneic eMSC which leads to differences in the short-term and long-term macrophage responses to implanted meshes.
Abstract The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In this study, we investigated the immunomodulatory effect of eMSC on the macrophage response to polyamide/gelatin composite mesh in an abdominal subcutaneous wound repair model in C57BL6 immunocompetent and NSG (NOD-Scid-IL2Rgamma null ) immunocompromised mice to determine whether responses differed in the absence of an adaptive immune system and NK cells. mCherry lentivirus-labelled eMSC persisted longer in NSG mice, inducing longer term paracrine effects. Inclusion of eMSC in the mesh reduced inflammatory cytokine (Il-1β, Tnfα) secretion, and in C57BL6 mice reduced CCR7 + M1 macrophages surrounding the mesh on day 3 and increased M2 macrophage marker mRNA ( Arg1 , Mrc1, Il10 ) expression at days 3 and 7. In NSG mice, these effects were delayed and only observed at days 7 and 30 in comparison with controls implanted with mesh alone. These results show that the differences in the immune status in the two animals directly affect the survival of xenogeneic eMSC which leads to differences in the short-term and long-term macrophage responses to implanted meshes.
The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In this study, we investigated the immunomodulatory effect of eMSC on the macrophage response to polyamide/gelatin composite mesh in an abdominal subcutaneous wound repair model in C57BL6 immunocompetent and NSG (NOD-Scid-IL2Rgamma null ) immunocompromised mice to determine whether responses differed in the absence of an adaptive immune system and NK cells. mCherry lentivirus-labelled eMSC persisted longer in NSG mice, inducing longer term paracrine effects. Inclusion of eMSC in the mesh reduced inflammatory cytokine (Il-1β, Tnfα) secretion, and in C57BL6 mice reduced CCR7 + M1 macrophages surrounding the mesh on day 3 and increased M2 macrophage marker mRNA ( Arg1 , Mrc1, Il10 ) expression at days 3 and 7. In NSG mice, these effects were delayed and only observed at days 7 and 30 in comparison with controls implanted with mesh alone. These results show that the differences in the immune status in the two animals directly affect the survival of xenogeneic eMSC which leads to differences in the short-term and long-term macrophage responses to implanted meshes.
The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated the chronic inflammatory response to a non-degradable polyamide/gelatin mesh in a xenogeneic rat skin wound repair model, but the mechanism remains unclear. In this study, we investigated the immunomodulatory effect of eMSC on the macrophage response to polyamide/gelatin composite mesh in an abdominal subcutaneous wound repair model in C57BL6 immunocompetent and NSG (NOD-Scid-IL2Rgamma ) immunocompromised mice to determine whether responses differed in the absence of an adaptive immune system and NK cells. mCherry lentivirus-labelled eMSC persisted longer in NSG mice, inducing longer term paracrine effects. Inclusion of eMSC in the mesh reduced inflammatory cytokine (Il-1β, Tnfα) secretion, and in C57BL6 mice reduced CCR7 M1 macrophages surrounding the mesh on day 3 and increased M2 macrophage marker mRNA (Arg1, Mrc1, Il10) expression at days 3 and 7. In NSG mice, these effects were delayed and only observed at days 7 and 30 in comparison with controls implanted with mesh alone. These results show that the differences in the immune status in the two animals directly affect the survival of xenogeneic eMSC which leads to differences in the short-term and long-term macrophage responses to implanted meshes.
ArticleNumber 6554
Author Gurung, S.
Darzi, S.
Werkmeister, J. A.
Nold, C. A.
Gough, D. J.
Mukherjee, S.
Gargett, C. E.
Deane, J. A.
Vashi, A. V.
Edwards, S. E.
Tan, K. S.
Author_xml – sequence: 1
  givenname: S.
  surname: Darzi
  fullname: Darzi, S.
  organization: The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University
– sequence: 2
  givenname: J. A.
  surname: Deane
  fullname: Deane, J. A.
  organization: The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University
– sequence: 3
  givenname: C. A.
  surname: Nold
  fullname: Nold, C. A.
  organization: The Ritchie Centre, Hudson Institute of Medical Research
– sequence: 4
  givenname: S. E.
  surname: Edwards
  fullname: Edwards, S. E.
  organization: CSIRO Manufacturing, Bayview Avenue
– sequence: 5
  givenname: D. J.
  surname: Gough
  fullname: Gough, D. J.
  organization: The Ritchie Centre, Hudson Institute of Medical Research
– sequence: 6
  givenname: S.
  surname: Mukherjee
  fullname: Mukherjee, S.
  organization: The Ritchie Centre, Hudson Institute of Medical Research
– sequence: 7
  givenname: S.
  surname: Gurung
  fullname: Gurung, S.
  organization: The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University
– sequence: 8
  givenname: K. S.
  surname: Tan
  fullname: Tan, K. S.
  organization: The Ritchie Centre, Hudson Institute of Medical Research
– sequence: 9
  givenname: A. V.
  surname: Vashi
  fullname: Vashi, A. V.
  organization: CSIRO Manufacturing, Bayview Avenue
– sequence: 10
  givenname: J. A.
  surname: Werkmeister
  fullname: Werkmeister, J. A.
  organization: The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University, CSIRO Manufacturing, Bayview Avenue
– sequence: 11
  givenname: C. E.
  orcidid: 0000-0002-3590-2077
  surname: Gargett
  fullname: Gargett, C. E.
  email: caroline.gargett@hudson.org.au
  organization: The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynaecology, Monash University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29700360$$D View this record in MEDLINE/PubMed
BookMark eNp9Ustu1DAUtVARfdAfYIEisWETxnachzdIaFTKSB2BaPeWx76ZpErsYDuV5ov4Te50ShlY4I3te88593lOTpx3QMgbRj8wWjSLKFgpm5yyJudCMplXL8gZp6LMecH5ydH7lFzGeE_xlFwKJl-RUy5rSouKnpGfV876EVLo9ZCtIYIz3W7E922CcXGbgt9_ljAMMVt7Ow86QZY6yNbaBD91egvZd4iTdxHtPluN06BdApt988NOj72FxTUgq3fZ0o-Tjz0KYKAuQ8tqHGfnDdoxTh-RpZ09skICl7J1b-A1ednqIcLl031B7j5f3S2_5Ddfr1fLTze5KQVNOW-srpuW6oZurCmM1kIUjNeibisKRloQ2ghbFVRQyWsLrG2plZtNaapWmuKCfDzITvNmBGswfNCDmkI_6rBTXvfqb4_rO7X1D6rEEaAgCrx_Egj-xwwxKazLYPu0Az9HxWnB9xlJjtB3_0Dv_RwcVrdHMUF5RQWi-AGF7Y4xQPucDKNqvwnqsAkKN0E9boKqkPT2uIxnyu-5I6A4ACK63BbCn9j_kf0FW93FaQ
CitedBy_id crossref_primary_10_1002_elsc_202000003
crossref_primary_10_1093_biolre_ioac158
crossref_primary_10_1186_s13578_020_00466_4
crossref_primary_10_1016_j_ejpb_2022_11_017
crossref_primary_10_1097_MOU_0000000000000625
crossref_primary_10_3389_fcell_2020_567610
crossref_primary_10_1016_j_intimp_2023_111397
crossref_primary_10_1093_rb_rbae032
crossref_primary_10_1016_j_intimp_2021_108404
crossref_primary_10_1097_MOU_0000000000000634
crossref_primary_10_3389_fcell_2018_00164
crossref_primary_10_1016_j_bbrc_2019_09_006
crossref_primary_10_1016_j_bioadv_2023_213669
crossref_primary_10_1016_j_reth_2022_05_008
crossref_primary_10_3390_jpm11090840
crossref_primary_10_1021_acs_biomac_8b01661
crossref_primary_10_3389_fphar_2020_00353
crossref_primary_10_1007_s00441_021_03453_4
crossref_primary_10_1016_j_biomaterials_2019_119495
crossref_primary_10_1016_j_actbio_2018_11_042
crossref_primary_10_3390_ijms22041708
crossref_primary_10_5582_bst_2020_03125
crossref_primary_10_3390_ijms222413385
crossref_primary_10_1016_j_actbio_2019_08_003
crossref_primary_10_3389_fbioe_2022_968482
crossref_primary_10_1016_j_apmt_2020_100890
crossref_primary_10_3389_fcell_2020_00497
crossref_primary_10_1098_rsfs_2018_0089
crossref_primary_10_1080_09205063_2021_1958184
crossref_primary_10_3389_fphar_2020_01332
Cites_doi 10.1126/science.8493529
10.1038/s41598-017-15217-8
10.1073/pnas.1306859110
10.1016/j.mattod.2015.01.019
10.1007/s00192-011-1476-2
10.1371/journal.pone.0001886
10.1165/rcmb.2010-0391OC
10.1093/humrep/dem265
10.1038/srep15042
10.1002/stem.2244
10.1016/j.actbio.2014.08.031
10.1073/pnas.90.20.9625
10.1097/AOG.0b013e3181f73729
10.4049/jimmunol.179.3.1855
10.1155/2015/968087
10.1111/j.1525-1594.2009.00749.x
10.1016/S0029-7844(97)00058-6
10.1007/s00192-005-0046-x
10.1038/nri2017
10.1038/nri3209
10.1517/14712598.2013.826187
10.1186/scrt532
10.1016/j.biomaterials.2010.07.032
10.1095/biolreprod.103.024109
10.1016/j.actbio.2016.07.003
10.1007/s00192-006-0202-y
10.1016/j.actbio.2014.10.043
10.1111/j.1525-1594.2011.01343.x
10.1016/j.jmbbm.2013.04.002
10.1163/1568562054798563
10.1016/j.exphem.2009.09.004
10.1095/biolreprod.115.136010
10.1007/s00464-010-1026-x
10.1038/nm.1905
10.1016/S0140-6736(99)90247-7
10.1016/j.actbio.2016.05.010
10.1016/j.smim.2007.11.004
10.1089/scd.2017.0177
10.1038/nmeth.2019
10.1093/humupd/dmw011
10.1111/luts.12098
10.5966/sctm.2015-0190
10.1371/journal.pone.0050044
10.1146/annurev-med-102715-092331
10.3727/096368911X637362
10.1002/14651858.CD004014.pub5
10.1002/jcb.24046
ContentType Journal Article
Copyright The Author(s) 2018
2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2018
– notice: 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
NPM
AAYXX
CITATION
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
DOI 10.1038/s41598-018-24919-6
DatabaseName Springer Nature OA Free Journals
PubMed
CrossRef
ProQuest Central (Corporate)
Health Medical collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Science Database
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database
CrossRef


PubMed
Database_xml – sequence: 1
  dbid: C6C
  name: Springer_OA刊
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 15
ExternalDocumentID 10_1038_s41598_018_24919_6
29700360
Genre Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
ADRAZ
AENEX
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IPNFZ
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNT
RNTTT
RPM
SNYQT
UKHRP
NPM
AAYXX
AFPKN
CITATION
7XB
8FK
K9.
PQEST
PQUKI
Q9U
7X8
5PM
ID FETCH-LOGICAL-c540t-28da78f0a80bdc3caa44312747f60ec9de4ac4d63040927de1ff0d9bb5c6f9c3
IEDL.DBID RPM
ISSN 2045-2322
IngestDate Tue Sep 17 21:13:42 EDT 2024
Thu Oct 24 23:58:58 EDT 2024
Sun Nov 10 07:02:34 EST 2024
Fri Aug 23 01:06:27 EDT 2024
Wed Oct 16 01:00:07 EDT 2024
Fri Oct 11 20:36:27 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-28da78f0a80bdc3caa44312747f60ec9de4ac4d63040927de1ff0d9bb5c6f9c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-3590-2077
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919927/
PMID 29700360
PQID 2031402604
PQPubID 2041939
PageCount 15
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919927
proquest_miscellaneous_2032431292
proquest_journals_2031402604
crossref_primary_10_1038_s41598_018_24919_6
pubmed_primary_29700360
springer_journals_10_1038_s41598_018_24919_6
PublicationCentury 2000
PublicationDate 2018-04-26
PublicationDateYYYYMMDD 2018-04-26
PublicationDate_xml – month: 04
  year: 2018
  text: 2018-04-26
  day: 26
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Olsen, Smith, Bergstrom, Colling, Clark (CR8) 1997; 89
Chapple (CR4) 2015; 7
Matsushima (CR13) 2009; 33
Ulrich (CR24) 2014; 20
Agrawal (CR41) 2014; 5
Vacanti, Langer (CR3) 1999; 354
Sridharan, Cameron, Kelly, Kearney, O’Brien (CR29) 2015; 18
Edwards (CR22) 2013; 23
Nemeth (CR31) 2009; 15
Konstantinovic (CR10) 2007; 18
Saldana (CR37) 2017; 7
Ionescu (CR35) 2012; 46
CR6
Zhao (CR15) 2012; 36
Barragan (CR39) 2016; 94
Luz-Crawford (CR38) 2016; 34
Darzi, Werkmeister, Deane, Gargett (CR18) 2016; 5
Darzi (CR49) 2016; 39
Maher, Feiner, Baessler, Schmid (CR7) 2013; 4
Dolce (CR14) 2010; 24
Shultz, Ishikawa, Greiner (CR33) 2007; 7
Ulrich, Muralitharan, Gargett (CR17) 2013; 13
Prockop, Oh (CR36) 2012; 113
Gigliobianco (CR5) 2015; 2015
Labow, Sa, Matheson, Santerre (CR28) 2005; 16
Schwab, Gargett (CR20) 2007; 22
Gurung, Deane, Darzi, Werkmeister, Gargett (CR42) 2018; 27
Su (CR46) 2014; 10
de Tayrac R (CR12) 2006; 17
Gupta (CR32) 2007; 179
Smith, Holman, Moorin, Tsokos (CR9) 2010; 116
CR19
Langer, Vacanti (CR1) 1993; 260
Edwards (CR25) 2015; 13
Schindelin (CR48) 2012; 9
Klopfleisch (CR34) 2016; 43
Nold (CR50) 2013; 110
Anderson, Rodriguez, Chang (CR26) 2008; 20
Shafiee, Atala (CR2) 2017; 68
Le Blanc, Mougiakakos (CR16) 2012; 12
Ulrich (CR23) 2012; 7
Kim, Hematti (CR30) 2009; 37
Tijdink, Vierhout, Heesakkers, Withagen (CR11) 2011; 22
Chan, Schwab, Gargett (CR44) 2004; 70
Serreze, Gaedeke, Leiter (CR40) 1993; 90
Gurung, Werkmeister, Gargett (CR45) 2015; 5
Xia (CR27) 1994; 107
Elvin (CR47) 2010; 31
Gargett, Schwab, Deane (CR21) 2016; 22
Chen, Tredget, Wu, Wu (CR43) 2008; 3
RS Labow (24919_CR28) 2005; 16
S Darzi (24919_CR18) 2016; 5
MM Tijdink (24919_CR11) 2011; 22
CM Elvin (24919_CR47) 2010; 31
MF Nold (24919_CR50) 2013; 110
DV Serreze (24919_CR40) 1993; 90
K Su (24919_CR46) 2014; 10
JM Anderson (24919_CR26) 2008; 20
SL Edwards (24919_CR25) 2015; 13
H Agrawal (24919_CR41) 2014; 5
KE Schwab (24919_CR20) 2007; 22
D Ulrich (24919_CR23) 2012; 7
D Ulrich (24919_CR17) 2013; 13
L Saldana (24919_CR37) 2017; 7
G Gigliobianco (24919_CR5) 2015; 2015
FJ Smith (24919_CR9) 2010; 116
SL Edwards (24919_CR22) 2013; 23
A Matsushima (24919_CR13) 2009; 33
ZD Xia (24919_CR27) 1994; 107
J Kim (24919_CR30) 2009; 37
R Klopfleisch (24919_CR34) 2016; 43
LI Ionescu (24919_CR35) 2012; 46
RW Chan (24919_CR44) 2004; 70
S Darzi (24919_CR49) 2016; 39
L Chen (24919_CR43) 2008; 3
J Schindelin (24919_CR48) 2012; 9
CJ Dolce (24919_CR14) 2010; 24
CR Chapple (24919_CR4) 2015; 7
Y Zhao (24919_CR15) 2012; 36
F Barragan (24919_CR39) 2016; 94
24919_CR6
S Gurung (24919_CR45) 2015; 5
A Shafiee (24919_CR2) 2017; 68
DX de Tayrac R (24919_CR12) 2006; 17
P Luz-Crawford (24919_CR38) 2016; 34
ML Konstantinovic (24919_CR10) 2007; 18
LD Shultz (24919_CR33) 2007; 7
C Maher (24919_CR7) 2013; 4
CE Gargett (24919_CR21) 2016; 22
DJ Prockop (24919_CR36) 2012; 113
K Nemeth (24919_CR31) 2009; 15
R Langer (24919_CR1) 1993; 260
JP Vacanti (24919_CR3) 1999; 354
24919_CR19
N Gupta (24919_CR32) 2007; 179
S Gurung (24919_CR42) 2018; 27
AL Olsen (24919_CR8) 1997; 89
R Sridharan (24919_CR29) 2015; 18
K Le Blanc (24919_CR16) 2012; 12
D Ulrich (24919_CR24) 2014; 20
References_xml – volume: 260
  start-page: 920
  year: 1993
  end-page: 926
  ident: CR1
  article-title: Tissue engineering
  publication-title: Science
  doi: 10.1126/science.8493529
  contributor:
    fullname: Vacanti
– volume: 7
  year: 2017
  ident: CR37
  article-title: Paracrine interactions between mesenchymal stem cells and macrophages are regulated by 1,25-dihydroxyvitamin D3
  publication-title: Scientific reports
  doi: 10.1038/s41598-017-15217-8
  contributor:
    fullname: Saldana
– volume: 110
  start-page: 14384
  year: 2013
  end-page: 14389
  ident: CR50
  article-title: Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.1306859110
  contributor:
    fullname: Nold
– volume: 18
  start-page: 313
  year: 2015
  ident: CR29
  article-title: Biomaterial based modulation of macrophage polarization: a review and suggested design principles
  publication-title: Materials Today
  doi: 10.1016/j.mattod.2015.01.019
  contributor:
    fullname: O’Brien
– volume: 20
  start-page: 785
  year: 2014
  end-page: 798
  ident: CR24
  article-title: Human Endometrial Mesenchymal Stem Cells Modulate the Tissue Response and Mechanical Behavior of Polyamide Mesh Implants for Pelvic Organ Prolapse Repair
  publication-title: Tissue Eng. Part A
  contributor:
    fullname: Ulrich
– volume: 22
  start-page: 1395
  year: 2011
  end-page: 1404
  ident: CR11
  article-title: Surgical management of mesh-related complications after prior pelvic floor reconstructive surgery with mesh
  publication-title: Int Urogynecol J
  doi: 10.1007/s00192-011-1476-2
  contributor:
    fullname: Withagen
– volume: 3
  start-page: e1886
  year: 2008
  ident: CR43
  article-title: Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing
  publication-title: PloS one
  doi: 10.1371/journal.pone.0001886
  contributor:
    fullname: Wu
– volume: 46
  start-page: 207
  year: 2012
  end-page: 216
  ident: CR35
  article-title: Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2010-0391OC
  contributor:
    fullname: Ionescu
– volume: 22
  start-page: 2903
  year: 2007
  end-page: 2911
  ident: CR20
  article-title: Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium
  publication-title: Hum Reprod
  doi: 10.1093/humrep/dem265
  contributor:
    fullname: Gargett
– volume: 5
  year: 2015
  ident: CR45
  article-title: Inhibition of Transforming Growth Factor-beta Receptor signaling promotes culture expansion of undifferentiated human Endometrial Mesenchymal Stem/stromalCells
  publication-title: Scientific reports
  doi: 10.1038/srep15042
  contributor:
    fullname: Gargett
– volume: 34
  start-page: 456
  year: 2016
  end-page: 469
  ident: CR38
  article-title: The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases
  publication-title: Stem Cells
  doi: 10.1002/stem.2244
  contributor:
    fullname: Luz-Crawford
– volume: 10
  start-page: 5012
  year: 2014
  end-page: 5020
  ident: CR46
  article-title: Induction of endometrial mesenchymal stem cells into tissue-forming cells suitable for fascial repair
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2014.08.031
  contributor:
    fullname: Su
– volume: 90
  start-page: 9625
  year: 1993
  end-page: 9629
  ident: CR40
  article-title: Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.90.20.9625
  contributor:
    fullname: Leiter
– volume: 116
  start-page: 1096
  year: 2010
  end-page: 1100
  ident: CR9
  article-title: Lifetime risk of undergoing surgery for pelvic organ prolapse
  publication-title: Obstet Gynecol
  doi: 10.1097/AOG.0b013e3181f73729
  contributor:
    fullname: Tsokos
– volume: 179
  start-page: 1855
  year: 2007
  end-page: 1863
  ident: CR32
  article-title: Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.3.1855
  contributor:
    fullname: Gupta
– volume: 2015
  start-page: 968087
  year: 2015
  ident: CR5
  article-title: Biomaterials for pelvic floor reconstructive surgery: how can we do better?
  publication-title: BioMed research international
  doi: 10.1155/2015/968087
  contributor:
    fullname: Gigliobianco
– ident: CR19
– volume: 33
  start-page: 474
  year: 2009
  end-page: 481
  ident: CR13
  article-title: osteogenic capability of human mesenchymal cells cultured on hydroxyapatite and on beta-tricalcium phosphate
  publication-title: Artif Organs
  doi: 10.1111/j.1525-1594.2009.00749.x
  contributor:
    fullname: Matsushima
– volume: 89
  start-page: 501
  year: 1997
  end-page: 506
  ident: CR8
  article-title: Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence
  publication-title: Obstet. Gynecol.
  doi: 10.1016/S0029-7844(97)00058-6
  contributor:
    fullname: Clark
– volume: 17
  start-page: 483
  year: 2006
  end-page: 488
  ident: CR12
  article-title: Long-term anatomical and functional assessment of trans-vaginal cystocele repair using a tension-free polypropylene mesh
  publication-title: Int Urogynecol J
  doi: 10.1007/s00192-005-0046-x
  contributor:
    fullname: de Tayrac R
– volume: 7
  start-page: 118
  year: 2007
  end-page: 130
  ident: CR33
  article-title: Humanized mice in translational biomedical research
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri2017
  contributor:
    fullname: Greiner
– volume: 12
  start-page: 383
  year: 2012
  end-page: 396
  ident: CR16
  article-title: Multipotent mesenchymal stromal cells and the innate immune system
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri3209
  contributor:
    fullname: Mougiakakos
– volume: 13
  start-page: 1387
  year: 2013
  end-page: 1400
  ident: CR17
  article-title: Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies
  publication-title: Expert Opinion on Biological Therapy
  doi: 10.1517/14712598.2013.826187
  contributor:
    fullname: Gargett
– volume: 5
  start-page: 142
  year: 2014
  ident: CR41
  article-title: Human adipose-derived stromal/stem cells demonstrate short-lived persistence after implantation in both an immunocompetent and an immunocompromised murine model
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt532
  contributor:
    fullname: Agrawal
– volume: 31
  start-page: 8323
  year: 2010
  end-page: 8331
  ident: CR47
  article-title: A highly elastic tissue sealant based on photopolymerised gelatin
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.07.032
  contributor:
    fullname: Elvin
– volume: 70
  start-page: 1738
  year: 2004
  end-page: 1750
  ident: CR44
  article-title: Clonogenicity of human endometrial epithelial and stromal cells
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.103.024109
  contributor:
    fullname: Gargett
– volume: 43
  start-page: 3
  year: 2016
  end-page: 13
  ident: CR34
  article-title: Macrophage reaction against biomaterials in the mouse model - Phenotypes, functions and markers
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2016.07.003
  contributor:
    fullname: Klopfleisch
– volume: 18
  start-page: 619
  year: 2007
  end-page: 626
  ident: CR10
  article-title: Tensile strength and host response towards different polypropylene implant materials used for augmentation of fascial repair in a rat model
  publication-title: International urogynecology journal and pelvic floor dysfunction
  doi: 10.1007/s00192-006-0202-y
  contributor:
    fullname: Konstantinovic
– volume: 4
  start-page: Cd004014
  year: 2013
  ident: CR7
  article-title: Surgical management of pelvic organ prolapse in women
  publication-title: Cochrane Database Syst Rev
  contributor:
    fullname: Schmid
– volume: 13
  start-page: 286
  year: 2015
  end-page: 294
  ident: CR25
  article-title: Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2014.10.043
  contributor:
    fullname: Edwards
– volume: 36
  start-page: 247
  year: 2012
  end-page: 255
  ident: CR15
  article-title: Abdominal hernia repair with a decellularized dermal scaffold seeded with autologous bone marrow-derived mesenchymal stem cells
  publication-title: Artif Organs
  doi: 10.1111/j.1525-1594.2011.01343.x
  contributor:
    fullname: Zhao
– volume: 23
  start-page: 53
  year: 2013
  end-page: 61
  ident: CR22
  article-title: Characterisation of clinical and newly fabricated meshes for pelvic organ prolapse repair
  publication-title: J Mech Behav Biomed Mater
  doi: 10.1016/j.jmbbm.2013.04.002
  contributor:
    fullname: Edwards
– volume: 16
  start-page: 1167
  year: 2005
  end-page: 1177
  ident: CR28
  article-title: Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation
  publication-title: Journal of biomaterials science. Polymer edition
  doi: 10.1163/1568562054798563
  contributor:
    fullname: Santerre
– volume: 37
  start-page: 1445
  year: 2009
  end-page: 1453
  ident: CR30
  article-title: Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2009.09.004
  contributor:
    fullname: Hematti
– volume: 94
  start-page: 118
  year: 2016
  ident: CR39
  article-title: Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.115.136010
  contributor:
    fullname: Barragan
– volume: 24
  start-page: 2687
  year: 2010
  end-page: 2693
  ident: CR14
  article-title: Pushing the envelope in biomaterial research: initial results of prosthetic coating with stem cells in a rat model
  publication-title: Surg Endosc
  doi: 10.1007/s00464-010-1026-x
  contributor:
    fullname: Dolce
– ident: CR6
– volume: 107
  start-page: 845
  year: 1994
  end-page: 849
  ident: CR27
  article-title: Macrophages in degradation of collagen/hydroxylapatite(CHA), beta-tricalcium phosphate ceramics (TCP) artificial bone graft. An study
  publication-title: Chinese medical journal
  contributor:
    fullname: Xia
– volume: 15
  start-page: 42
  year: 2009
  end-page: 49
  ident: CR31
  article-title: Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
  publication-title: Nat Med
  doi: 10.1038/nm.1905
  contributor:
    fullname: Nemeth
– volume: 354
  start-page: Si32
  issue: Suppl 1
  year: 1999
  end-page: 34
  ident: CR3
  article-title: Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation
  publication-title: Lancet
  doi: 10.1016/S0140-6736(99)90247-7
  contributor:
    fullname: Langer
– volume: 39
  start-page: 114
  year: 2016
  end-page: 123
  ident: CR49
  article-title: Tissue response to collagen containing polypropylene meshes in an ovine vaginal repair model
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2016.05.010
  contributor:
    fullname: Darzi
– volume: 20
  start-page: 86
  year: 2008
  end-page: 100
  ident: CR26
  article-title: Foreign body reaction to biomaterials
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2007.11.004
  contributor:
    fullname: Chang
– volume: 27
  start-page: 35
  year: 2018
  end-page: 43
  ident: CR42
  article-title: Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice
  publication-title: Stem cells and development
  doi: 10.1089/scd.2017.0177
  contributor:
    fullname: Gargett
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: CR48
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 22
  start-page: 137
  year: 2016
  end-page: 163
  ident: CR21
  article-title: Endometrial stem/progenitor cells: the first 10 years
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmw011
  contributor:
    fullname: Deane
– volume: 113
  start-page: 1460
  year: 2012
  end-page: 1469
  ident: CR36
  article-title: Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results to the cellular and molecular explanations
  publication-title: J Cell Biochem
  contributor:
    fullname: Oh
– volume: 7
  start-page: 63
  year: 2015
  end-page: 70
  ident: CR4
  article-title: Application of Tissue Engineering to Pelvic Organ Prolapse and Stress Urinary Incontinence
  publication-title: Lower urinary tract symptoms
  doi: 10.1111/luts.12098
  contributor:
    fullname: Chapple
– volume: 5
  start-page: 1127
  year: 2016
  end-page: 1132
  ident: CR18
  article-title: Identification and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells and Their Potential for Cellular Therapy
  publication-title: Stem Cells Transl Med
  doi: 10.5966/sctm.2015-0190
  contributor:
    fullname: Gargett
– volume: 7
  start-page: e50044
  year: 2012
  ident: CR23
  article-title: A preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0050044
  contributor:
    fullname: Ulrich
– volume: 68
  start-page: 29
  year: 2017
  end-page: 40
  ident: CR2
  article-title: Tissue Engineering: Toward a New Era of Medicine
  publication-title: Annu Rev Med
  doi: 10.1146/annurev-med-102715-092331
  contributor:
    fullname: Atala
– volume: 18
  start-page: 313
  year: 2015
  ident: 24919_CR29
  publication-title: Materials Today
  doi: 10.1016/j.mattod.2015.01.019
  contributor:
    fullname: R Sridharan
– volume: 94
  start-page: 118
  year: 2016
  ident: 24919_CR39
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.115.136010
  contributor:
    fullname: F Barragan
– ident: 24919_CR19
  doi: 10.3727/096368911X637362
– volume: 10
  start-page: 5012
  year: 2014
  ident: 24919_CR46
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2014.08.031
  contributor:
    fullname: K Su
– volume: 37
  start-page: 1445
  year: 2009
  ident: 24919_CR30
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2009.09.004
  contributor:
    fullname: J Kim
– volume: 13
  start-page: 1387
  year: 2013
  ident: 24919_CR17
  publication-title: Expert Opinion on Biological Therapy
  doi: 10.1517/14712598.2013.826187
  contributor:
    fullname: D Ulrich
– volume: 116
  start-page: 1096
  year: 2010
  ident: 24919_CR9
  publication-title: Obstet Gynecol
  doi: 10.1097/AOG.0b013e3181f73729
  contributor:
    fullname: FJ Smith
– volume: 110
  start-page: 14384
  year: 2013
  ident: 24919_CR50
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.1306859110
  contributor:
    fullname: MF Nold
– volume: 89
  start-page: 501
  year: 1997
  ident: 24919_CR8
  publication-title: Obstet. Gynecol.
  doi: 10.1016/S0029-7844(97)00058-6
  contributor:
    fullname: AL Olsen
– volume: 24
  start-page: 2687
  year: 2010
  ident: 24919_CR14
  publication-title: Surg Endosc
  doi: 10.1007/s00464-010-1026-x
  contributor:
    fullname: CJ Dolce
– volume: 43
  start-page: 3
  year: 2016
  ident: 24919_CR34
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2016.07.003
  contributor:
    fullname: R Klopfleisch
– volume: 18
  start-page: 619
  year: 2007
  ident: 24919_CR10
  publication-title: International urogynecology journal and pelvic floor dysfunction
  doi: 10.1007/s00192-006-0202-y
  contributor:
    fullname: ML Konstantinovic
– volume: 3
  start-page: e1886
  year: 2008
  ident: 24919_CR43
  publication-title: PloS one
  doi: 10.1371/journal.pone.0001886
  contributor:
    fullname: L Chen
– volume: 39
  start-page: 114
  year: 2016
  ident: 24919_CR49
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2016.05.010
  contributor:
    fullname: S Darzi
– volume: 7
  start-page: 118
  year: 2007
  ident: 24919_CR33
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri2017
  contributor:
    fullname: LD Shultz
– ident: 24919_CR6
– volume: 107
  start-page: 845
  year: 1994
  ident: 24919_CR27
  publication-title: Chinese medical journal
  contributor:
    fullname: ZD Xia
– volume: 5
  year: 2015
  ident: 24919_CR45
  publication-title: Scientific reports
  doi: 10.1038/srep15042
  contributor:
    fullname: S Gurung
– volume: 22
  start-page: 137
  year: 2016
  ident: 24919_CR21
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmw011
  contributor:
    fullname: CE Gargett
– volume: 7
  start-page: 63
  year: 2015
  ident: 24919_CR4
  publication-title: Lower urinary tract symptoms
  doi: 10.1111/luts.12098
  contributor:
    fullname: CR Chapple
– volume: 4
  start-page: Cd004014
  year: 2013
  ident: 24919_CR7
  publication-title: Cochrane Database Syst Rev
  doi: 10.1002/14651858.CD004014.pub5
  contributor:
    fullname: C Maher
– volume: 179
  start-page: 1855
  year: 2007
  ident: 24919_CR32
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.3.1855
  contributor:
    fullname: N Gupta
– volume: 31
  start-page: 8323
  year: 2010
  ident: 24919_CR47
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.07.032
  contributor:
    fullname: CM Elvin
– volume: 15
  start-page: 42
  year: 2009
  ident: 24919_CR31
  publication-title: Nat Med
  doi: 10.1038/nm.1905
  contributor:
    fullname: K Nemeth
– volume: 7
  year: 2017
  ident: 24919_CR37
  publication-title: Scientific reports
  doi: 10.1038/s41598-017-15217-8
  contributor:
    fullname: L Saldana
– volume: 23
  start-page: 53
  year: 2013
  ident: 24919_CR22
  publication-title: J Mech Behav Biomed Mater
  doi: 10.1016/j.jmbbm.2013.04.002
  contributor:
    fullname: SL Edwards
– volume: 90
  start-page: 9625
  year: 1993
  ident: 24919_CR40
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.90.20.9625
  contributor:
    fullname: DV Serreze
– volume: 20
  start-page: 785
  year: 2014
  ident: 24919_CR24
  publication-title: Tissue Eng. Part A
  contributor:
    fullname: D Ulrich
– volume: 20
  start-page: 86
  year: 2008
  ident: 24919_CR26
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2007.11.004
  contributor:
    fullname: JM Anderson
– volume: 68
  start-page: 29
  year: 2017
  ident: 24919_CR2
  publication-title: Annu Rev Med
  doi: 10.1146/annurev-med-102715-092331
  contributor:
    fullname: A Shafiee
– volume: 27
  start-page: 35
  year: 2018
  ident: 24919_CR42
  publication-title: Stem cells and development
  doi: 10.1089/scd.2017.0177
  contributor:
    fullname: S Gurung
– volume: 17
  start-page: 483
  year: 2006
  ident: 24919_CR12
  publication-title: Int Urogynecol J
  doi: 10.1007/s00192-005-0046-x
  contributor:
    fullname: DX de Tayrac R
– volume: 36
  start-page: 247
  year: 2012
  ident: 24919_CR15
  publication-title: Artif Organs
  doi: 10.1111/j.1525-1594.2011.01343.x
  contributor:
    fullname: Y Zhao
– volume: 12
  start-page: 383
  year: 2012
  ident: 24919_CR16
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri3209
  contributor:
    fullname: K Le Blanc
– volume: 13
  start-page: 286
  year: 2015
  ident: 24919_CR25
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2014.10.043
  contributor:
    fullname: SL Edwards
– volume: 260
  start-page: 920
  year: 1993
  ident: 24919_CR1
  publication-title: Science
  doi: 10.1126/science.8493529
  contributor:
    fullname: R Langer
– volume: 5
  start-page: 1127
  year: 2016
  ident: 24919_CR18
  publication-title: Stem Cells Transl Med
  doi: 10.5966/sctm.2015-0190
  contributor:
    fullname: S Darzi
– volume: 22
  start-page: 2903
  year: 2007
  ident: 24919_CR20
  publication-title: Hum Reprod
  doi: 10.1093/humrep/dem265
  contributor:
    fullname: KE Schwab
– volume: 7
  start-page: e50044
  year: 2012
  ident: 24919_CR23
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0050044
  contributor:
    fullname: D Ulrich
– volume: 22
  start-page: 1395
  year: 2011
  ident: 24919_CR11
  publication-title: Int Urogynecol J
  doi: 10.1007/s00192-011-1476-2
  contributor:
    fullname: MM Tijdink
– volume: 2015
  start-page: 968087
  year: 2015
  ident: 24919_CR5
  publication-title: BioMed research international
  doi: 10.1155/2015/968087
  contributor:
    fullname: G Gigliobianco
– volume: 34
  start-page: 456
  year: 2016
  ident: 24919_CR38
  publication-title: Stem Cells
  doi: 10.1002/stem.2244
  contributor:
    fullname: P Luz-Crawford
– volume: 354
  start-page: Si32
  issue: Suppl 1
  year: 1999
  ident: 24919_CR3
  publication-title: Lancet
  doi: 10.1016/S0140-6736(99)90247-7
  contributor:
    fullname: JP Vacanti
– volume: 16
  start-page: 1167
  year: 2005
  ident: 24919_CR28
  publication-title: Journal of biomaterials science. Polymer edition
  doi: 10.1163/1568562054798563
  contributor:
    fullname: RS Labow
– volume: 33
  start-page: 474
  year: 2009
  ident: 24919_CR13
  publication-title: Artif Organs
  doi: 10.1111/j.1525-1594.2009.00749.x
  contributor:
    fullname: A Matsushima
– volume: 5
  start-page: 142
  year: 2014
  ident: 24919_CR41
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt532
  contributor:
    fullname: H Agrawal
– volume: 9
  start-page: 676
  year: 2012
  ident: 24919_CR48
  publication-title: Nat Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: J Schindelin
– volume: 46
  start-page: 207
  year: 2012
  ident: 24919_CR35
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2010-0391OC
  contributor:
    fullname: LI Ionescu
– volume: 70
  start-page: 1738
  year: 2004
  ident: 24919_CR44
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.103.024109
  contributor:
    fullname: RW Chan
– volume: 113
  start-page: 1460
  year: 2012
  ident: 24919_CR36
  publication-title: J Cell Biochem
  doi: 10.1002/jcb.24046
  contributor:
    fullname: DJ Prockop
SSID ssj0000529419
Score 2.4355686
Snippet The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC modulated...
Abstract The immunomodulatory properties of human endometrial mesenchymal stem cells (eMSC) have not been well characterised. Initial studies showed that eMSC...
SourceID pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 6554
SubjectTerms 13
13/100
13/106
13/107
13/109
13/21
13/31
14/19
38/77
631/250/2504
631/532/2074
64/60
692/308/2171
CCR7 protein
Cytokines
Endometrium
Gelatin
Gene expression
Humanities and Social Sciences
Immune status
Immune system
Immunocompetence
Immunomodulation
Inflammation
Interleukin 1
Interleukin 10
Macrophages
Mesenchyme
mRNA
multidisciplinary
Paracrine signalling
Pelvic organ prolapse
Polyamides
Science
Science (multidisciplinary)
Skin
Stem cell transplantation
Stem cells
Stromal cells
Tissue engineering
Tumor necrosis factor-TNF
Wound healing
SummonAdditionalLinks – databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVkhcEO8GCjISN7DWSZw4PiGothSkVFVbpN4ix3a0K-0mpUkP-4v4m8wk2S1LBbfEduRMZjIeex4fwPuk8qQDPVeo-7jMwoqb2FY867GQnFAqpGzk_CQ9_iG_XyaX44FbO4ZVbnRir6hdY-mMHDfpMe4F0PqWn65-ckKNIu_qCKFxH_Yi7BUT2PsyOzk9256ykB9LhnrMlhFxNm1xxaKsshAFROpQ83R3RbpjZt6NlvzLZdqvREeP4dFoQrLPA8-fwD1fP4UHA6jk-hn8mtWuWfkejoPllFxk5-sVXp93fjU9764bujn0y2XL8sYRfJdnaAay3BCc1xwVDDsbImexvWFUP5g-v2OnzXJtVgvnp1_7ELqakTahqC9PE80ZtnyjfJOGAtVxnkWLT5na_dFKNnrHclRPz-HiaHZxeMxHOAZu0azreJQ5o7JKmEyUzsbWGInWB-1qq1R4q52XxkqXxqgXdKScD6tKOF2WiU0rbeMXMKmb2u8DUyaJRKnL1GexxOe1Sqw2mZTCKFxJXQAfNhwproaiG0XvLI-zYuBfgfwrev4VaQAHG6YV4w_YFrfiEsC7bTfSTf4QU_vmph8TEQU6CuDlwOPtdJFWVKpHBKB2uL8dQGW5d3vqxbwvz51oCulVAXzcyMnta_2bilf_p-I1PIxIZoXkUXoAk-76xr9Bc6gr344y_xtz1Ayd
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VIiQuiHdTCjISNzCbOE4cHxBCVUtBCkK0lXqLHNvRrrSb0N1UYn8Rf5OZPBaWlgO3xA85zjcef5bnAfAqqTzpQM8V6j4us6jiJrYVz7pcSC5UKiJv5PxLenIuP18kFzswpjsafuDqxqMd5ZM6X87f_rhcv8cF_653Gc8mK9yEyFEsQsyljjRPb8FtIfGkTqZ8A93vY30LLSM9-M7c3HV7f7pGOq_bTv51gdrtS8f34d5AKNmHXgIewI6vH8KdPsXk-hH8PKpds_Bdcg6Wk6uRna4X-Hza-sXktF029HLo5_MVyxtHybw8Q1LIckPJvaaobti33o4WyxtG0YQJDMe-NvO1Wcycn3zsDOpqRrqFbMA8DTRlWPKJvE8aMlvHcWYr7GVq90cpMfaW5aisHsPZ8dHZ4QkfkjNwiySv5SJzRmVVaLKwdDa2xkjkInTGrdLQW-28NFa6NEYtoYVyPqqq0OmyTGxaaRs_gd26qf0eMGUSEZa6TH0WS-yvVWK1yaQMjcJ91QXwekSk-N6H4Ci6q_M4K3r8CsSv6PAr0gAORtCKUZoKQUH6KXqaDODlphrnTbcjpvbNVddG0Ay0COBpj_FmOKEVBe4JA1Bb6G8aUJDu7Zp6Nu2CdSeaDHxVAG9GOfn9Wf-exf7_NX8GdwXJcCi5SA9gt11e-edIltryRbcCfgHryhLx
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagCIkLorwa2iIjcQNrE8fx44hWLQUpCNEi9RY5tqNdaTdB3fSwv4i_2Rknu3RbOHBL_JDjfMnMJDPzDSHviyagDAxMgexjQmcNs7lrmI61kHyqVIbZyOU3efZTfL0sLkeaHMyF2fHf53qyAgWDSWAZ4ClMZph8SB6BDtYYvjWV0-3_FPRYicyMeTF_n7qre-4ZlPfjIu84R6POOX1Gno7GIv00oLtPHoT2OXk8lI9cvyC_T1rfLUMsvEFLTCNys_USjs_7sJyc91cdnkzDYrGiZeexUFegYPDR0mLhrhmIEvpjiJGF9o4iUzDeaE-_d4u1Xc59mHyOwXItRbmB8V0BF5pRaPmCmSUdhqTDOvMVzLKtv9WK1nhPSxBEL8nF6cnF9IyNhReYAwOuZ1x7q3STWp3W3uXOWgF2Bn6_NjINzvggrBNe5iABDFc-ZE2TelPXhZONcfkrstd2bTggVNmCp7WpZdC5gPlGFc5YLURqFehMn5APG0SqXwO9RhXd4rmuBvwqwK-K-FUyIUcb0KrxVVtVHAn4kRlNJOTdthv2jZ4P24buOo7huAPDE_J6wHi7HDcKSXnShKgd9LcDkIB7t6edzyIRd2EweFcl5OPmOflzWf_exZv_G35InnB8hlPBuDwie_3VdTgGQ6iv38Y34AZihgRz
  priority: 102
  providerName: Springer Nature
Title Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice
URI https://link.springer.com/article/10.1038/s41598-018-24919-6
https://www.ncbi.nlm.nih.gov/pubmed/29700360
https://www.proquest.com/docview/2031402604
https://search.proquest.com/docview/2032431292
https://pubmed.ncbi.nlm.nih.gov/PMC5919927
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbaIiQuiHcDZWUkbpDm5cT2EVZbClKqVVukvUWO7WhX2iRVNz3sL-JvMuMkS5eKC5cofsl2Zjwex9_MEPIxrSzKQOtzkH0-E1Hlq0RXvnCxkEzIeYTWyPlFdv6T_VikiwOSjrYwDrSvy9Vps65Pm9XSYStvah2MOLFgnk9TiaBJHhySQ2DQe0f03qF3LFkkBwOZMBHBBjYpNCSLgCcYNPUxblEsOfpiCff3owdK5kOs5F8Xpm4fOntGng4KJP3SD_Q5ObDNC_K4Dym5fUl-zRrT1tYF46A5mhbp5baG96vO1sFVd9tiYmrX6w3NW4PBuywFJZDmCoN5LUG80MseNwv5LUXvwfjxDZ23662qV8YG3xyArqEoSxDzZbGjJYWc72ht0iJMHfpZbaCVasy9XNTQO5qDcHpFrs9m19NzfwjG4GtQ6jo_FkZxUYVKhKXRiVaKge6BZ9oqC62WxjKlmckSkApAG2OjqgqNLMtUZ5XUyWty1LSNPSaUqzQOS1lmViQM2kueaqkEY6HisI8aj3waKVLc9C43CndVnoiiJ2UBpCwcKYvMIycj0Yph-W2KGJ3yo7c05pEPu2KYN96GqMa2d65OjDOQsUfe9DTedTcyh0f4HvV3FdAp934J8Kpzzj3wpkc-j3zyZ1j_nsXb_-7oHXkSI2eHzI-zE3LU3d7Z96AndeUEVseCT8ijr7OL-SWkptl04v45wDNnYuLWzW9ZxRma
link.rule.ids 230,315,730,783,787,867,888,12068,21400,24330,27936,27937,31731,31732,33756,33757,41132,42201,43322,43817,51588,53804,53806,74079,74636
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgCMEL4nMENjASb2DVSZw4fpqmaaODZUKsSH2LHNtRK7XJWLKH_kX8m9w5aUc3wVtiO3Kcu9ydfR8_Qj4mlUMZ6JgE2cdEFlZMx6ZimcdCslzKELOR8_N0_FN8nSbT4cCtHcIq1zLRC2rbGDwjh016DHsBsL7FweUvhqhR6F0dIDTukwdYhwsRDORUbs5Y0IslQjXkyvA4G7WgrzCnLAT2ECpULN3WR3eMzLuxkrccpl4PnTwlTwYDkh72FH9G7rn6OXnYQ0quXpDfx7Vtls6DcdAcU4vMbLWE64vOLUcX3VWDN0dusWhp3lgE73IUjECaawTzmoF4oT_6uFlobyhWD8aPb-n3ZrHSy7l1oy8-gK6mKEsw5svhRDMKLaeYbdJgmDrMM2_hKV3bv1rRQu9oDsLpJZmcHE-OxmwAY2AGjLqORZnVMqu4znhpTWy0FmB74J62SrkzyjqhjbBpDFJBRdK6sKq4VWWZmLRSJn5Fduqmdq8JlTqJeKnK1GWxgOeVTIzSmRBcS9CjNiCf1hQpLvuSG4V3lcdZ0dOvAPoVnn5FGpC9NdGK4fdrixtmCciHTTesG70hunbNtR8T4QpUFJDdnsab6SIlsVAPD4jcov5mABbl3u6p5zNfnDtRGNArA_J5zSc3r_XvVbz5_yrek0fjSX5WnJ2ef3tLHkfIv1ywKN0jO93VtdsHw6gr33nu_wO_WQ4o
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwELWgCMSlKt8pLRiJG1jrJE4cn1DVdmmBVBUt0t4ix3a0K-0mpUkP-4v4m8w42S1LBbfEseVYbzIeZ97MEPI-qRzqQMck6D4msrBiOjYVy3wtJMulDDEaOT9LT36IL5NkMvCf2oFWudKJXlHbxuA_cjikx3AWAOtbjKqBFnF-NP509ZNhBSn0tA7lNO6TBxJOKSjhciLX_1vQoyVCNcTN8DgbtbB3YXxZCKIiVKhYurk33TE47_Im_3Ke-j1pvEO2B2OSHvToPyH3XP2UPOzLSy6fkV_HtW0WzhfmoDmGGZnpcgHXF51bjC666wZvDt183tK8sVjIy1EwCGmusbDXFFQN_d5zaKG9oZhJGIGw9LyZL_ViZt3osyfT1RT1CvK_HE40pdByipEnDVLWYZ5ZC6N0bf9oRWu9ozkoqufkcnx8eXjChsIMzICB17Eos1pmFdcZL62JjdYC7BA831Ypd0ZZJ7QRNo1BQ6hIWhdWFbeqLBOTVsrEL8hW3dTuFaFSJxEvVZm6LBYwXsnEKJ0JwbWEPdUG5MMKkeKqT79ReLd5nBU9fgXgV3j8ijQgeyvQiuFTbItbwQnIu_VjWDd6RnTtmhvfJ8IVqCggL3uM19NFSmLSHh4QuYH-ugMm6N58Us-mPlF3opDcKwPycSUnt6_171Xs_n8Vb8kjEPzi2-nZ19fkcYTiywWL0j2y1V3fuH2wkbryjRf-32ULEmY
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Endometrial+Mesenchymal+Stem%2FStromal+Cells+Modulate+the+Macrophage+Response+to+Implanted+Polyamide%2FGelatin+Composite+Mesh+in+Immunocompromised+and+Immunocompetent+Mice&rft.jtitle=Scientific+reports&rft.au=Darzi%2C+S.&rft.au=Deane%2C+J.+A.&rft.au=Nold%2C+C.+A.&rft.au=Edwards%2C+S.+E.&rft.date=2018-04-26&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=8&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-018-24919-6&rft.externalDocID=10_1038_s41598_018_24919_6
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon