Membrane-associated RING-CH protein (MARCH8) is a novel glycolysis repressor targeted by miR-32 in colorectal cancer

• Published in: Journal of translational medicine Vol. 20; no. 1; pp. 1 - 13
• Main Authors: Wang, Zhan, Wang, Miao-Miao, Geng, Yan, Ye, Chen-Yang, Zang, Yuan-Sheng
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 05.09.2022; BioMed Central; BMC
• Subjects: Antibodies; Antigens; Biomarkers; Breast cancer; Cancer; Cancer therapies; Care and treatment; Cell culture; Chromatin; Cloning; Colorectal cancer; Colorectal carcinoma; Gene silencing; Glycolysis; Health aspects; Hexokinase; HK2; Medical prognosis; Membrane proteins; Membrane-associated RING-CH protein 8 (MARCH8); Membranes; Metabolism; Metastasis; MicroRNA; miR-32; Packaging; Patients; Plasmids; Proteasomes; Proteins; Risk factors; Survival analysis; Tumor proteins; Tumors; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Xenografts; China; United States > US

Background Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer-related deaths worldwide. Aberrant cellular metabolism is a hallmark of cancer cells, and disturbed metabolism showed clinical significance in CRC. The membrane-associated RING-CH 8 (MARCH8) protein, the f...