Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy

• Published in: Cell death & disease Vol. 12; no. 11; pp. 1069 - 13
• Main Authors: Wang, Weichen, Wang, Longlong, Yang, Mengyue, Wu, Chunwei, Lan, Rui, Wang, Weiwei, Li, Yuze
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.11.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/109; 45/77; 631/61; 631/80; Angiotensin; Angiotensin II; Animals; Antibodies; Aorta; Autophagy; Autophagy - genetics; Biochemistry; Biomedical and Life Sciences; Cardiomegaly - genetics; Cardiomegaly - pathology; Cardiomyocytes; Cell Biology; Cell Culture; Disease Models, Animal; Heart; Humans; Hypertrophy; Immunology; Life Sciences; Mice; Phagocytosis; Post-transcription; Post-translation; RNA, Circular - genetics; SIRT1 protein; Sirtuin 1 - metabolism; Transfection; Up-Regulation

Mounting studies have substantiated that abrogating autophagy contributes to cardiac hypertrophy (CH). Sirtuin 1 (SIRT1) has been reported to support autophagy and inhibit CH. However, the upstream regulation mechanism behind the regulation of SIRT1 level in CH remains unclear. Circular RNAs (circRN...