Detection technologies for RNA modifications

• Published in: Experimental & molecular medicine Vol. 54; no. 10; pp. 1601 - 1616
• Main Authors: Zhang, Yan, Lu, Liang, Li, Xiaoyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2022; Springer Nature B.V
• Subjects: 38; 38/91; 631/1647; 631/208/514; Biomedical and Life Sciences; Biomedicine; Epigenetics; Gene expression; Gene Expression Regulation; Gene regulation; High-Throughput Nucleotide Sequencing - methods; Medical Biochemistry; Molecular Medicine; Next-generation sequencing; Nucleotide sequence; Review; Review Article; RNA - genetics; RNA - metabolism; RNA modification; Sequence Analysis, RNA; Stem Cells

To date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome. According to the detection throughput...