Reversing insecticide resistance with allelic-drive in Drosophila melanogaster

A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred to as knockdown resistance or kdr ) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a ma...

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Published inNature communications Vol. 13; no. 1; p. 291
Main Authors Kaduskar, Bhagyashree, Kushwah, Raja Babu Singh, Auradkar, Ankush, Guichard, Annabel, Li, Menglin, Bennett, Jared B., Julio, Alison Henrique Ferreira, Marshall, John M., Montell, Craig, Bier, Ethan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.01.2022
Nature Publishing Group
Nature Portfolio
Subjects
42/41
45/70
631/208/2156
631/61/17/1511
64/24
Alleles
Animals
CRISPR
CRISPR-Cas Systems
Culicidae
DDT
Deltamethrin
Directional control
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Female
Fruit flies
Genetic Engineering
Global health
Humanities and Social Sciences
Insecticide resistance
Insecticide Resistance - genetics
Insecticides
Insects
Laboratories
Malaria
Male
multidisciplinary
Mutation
Parasite resistance
Parasites
Permethrin
Pesticide resistance
Pests
Public health
Pyrethroids
Reversion
Science
Science (multidisciplinary)
Sodium channels (voltage-gated)
Vector-borne diseases
Vectors
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Abstract A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred to as knockdown resistance or kdr ) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a major global threat to the continued use of insecticides as a means for vector control. In this study, we generate common kdr mutations in isogenic laboratory Drosophila strains using CRISPR/Cas9 editing. We identify differential sensitivities to permethrin and DDT versus deltamethrin among these mutants as well as contrasting physiological consequences of two different kdr mutations. Importantly, we apply a CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens-up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria transmitting mosquitoes with those bearing naturally occurring parasite resistant alleles. Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.
AbstractList Abstract A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred to as knockdown resistance or kdr ) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a major global threat to the continued use of insecticides as a means for vector control. In this study, we generate common kdr mutations in isogenic laboratory Drosophila strains using CRISPR/Cas9 editing. We identify differential sensitivities to permethrin and DDT versus deltamethrin among these mutants as well as contrasting physiological consequences of two different kdr mutations. Importantly, we apply a CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens-up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria transmitting mosquitoes with those bearing naturally occurring parasite resistant alleles.
Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred to as knockdown resistance or kdr ) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a major global threat to the continued use of insecticides as a means for vector control. In this study, we generate common kdr mutations in isogenic laboratory Drosophila strains using CRISPR/Cas9 editing. We identify differential sensitivities to permethrin and DDT versus deltamethrin among these mutants as well as contrasting physiological consequences of two different kdr mutations. Importantly, we apply a CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens-up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria transmitting mosquitoes with those bearing naturally occurring parasite resistant alleles. Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a major global threat to the continued use of insecticides as a means for vector control. In this study, we generate common kdr mutations in isogenic laboratory Drosophila strains using CRISPR/Cas9 editing. We identify differential sensitivities to permethrin and DDT versus deltamethrin among these mutants as well as contrasting physiological consequences of two different kdr mutations. Importantly, we apply a CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens-up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria transmitting mosquitoes with those bearing naturally occurring parasite resistant alleles.Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a CRISPR-based allelic-drive to replace an IR allele with a susceptible wild-type counterpart, providing a potent new tool for vector control.
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer resistance to commonly used insecticides, pyrethroids and DDT. The ubiquity of kdr mutations poses a major global threat to the continued use of insecticides as a means for vector control. In this study, we generate common kdr mutations in isogenic laboratory Drosophila strains using CRISPR/Cas9 editing. We identify differential sensitivities to permethrin and DDT versus deltamethrin among these mutants as well as contrasting physiological consequences of two different kdr mutations. Importantly, we apply a CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens-up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria transmitting mosquitoes with those bearing naturally occurring parasite resistant alleles.
ArticleNumber 291
Author Julio, Alison Henrique Ferreira
Kaduskar, Bhagyashree
Auradkar, Ankush
Kushwah, Raja Babu Singh
Marshall, John M.
Bier, Ethan
Guichard, Annabel
Montell, Craig
Li, Menglin
Bennett, Jared B.
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  email: ebier@ucsd.edu
  organization: Section of Cell and Developmental Biology, University of California, San Diego, Tata Institute for Genetics and Society, University of California, San Diego
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Snippet A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred to as...
A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as...
Abstract A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel ( vgsc ) gene (often referred...
Insecticide resistance (IR) poses a major global health challenge. Here, the authors generate common IR mutations in laboratory Drosophila strains and use a...
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SubjectTerms 42/41
45/70
631/208/2156
631/61/17/1511
64/24
Alleles
Animals
CRISPR
CRISPR-Cas Systems
Culicidae
DDT
Deltamethrin
Directional control
Drosophila
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Female
Fruit flies
Genetic Engineering
Global health
Humanities and Social Sciences
Insecticide resistance
Insecticide Resistance - genetics
Insecticides
Insects
Laboratories
Malaria
Male
multidisciplinary
Mutation
Parasite resistance
Parasites
Permethrin
Pesticide resistance
Pests
Public health
Pyrethroids
Reversion
Science
Science (multidisciplinary)
Sodium channels (voltage-gated)
Vector-borne diseases
Vectors
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Title Reversing insecticide resistance with allelic-drive in Drosophila melanogaster
URI https://link.springer.com/article/10.1038/s41467-021-27654-1
https://www.ncbi.nlm.nih.gov/pubmed/35022402
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https://search.proquest.com/docview/2619541892
https://pubmed.ncbi.nlm.nih.gov/PMC8755802
https://doaj.org/article/f9c5e9f5132e4a7aa564c5c7a2289e58
Volume 13
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