The deficiency of poly-β-1,6-N-acetyl-glucosamine deacetylase trigger A. baumannii to convert to biofilm-independent colistin-tolerant cells

• Published in: Scientific reports Vol. 13; no. 1; pp. 2800 - 14
• Main Authors: Lai, Shu-Jung, Tu, I-Fan, Tseng, Tien-Sheng, Tsai, Yu-Hsuan, Wu, Shih-Hsiung
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/22; 631/326/421; 631/326/46; 692/420; Acinetobacter baumannii; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotics; Biofilms; Colistin; Colistin - metabolism; Colistin - pharmacology; Drug Resistance, Multiple, Bacterial; Glucosamine; Glucosamine - metabolism; Humanities and Social Sciences; Microbial Sensitivity Tests; multidisciplinary; Multidrug resistance; N-Acetylglucosamine; Nosocomial infection; Pathogens; Science; Science (multidisciplinary)

Acinetobacter baumannii is a nosocomial pathogen that can be resistant to antibiotics by rapidly modulating its anti-drug mechanisms. The multidrug-resistant A. baumannii has been considered one of the most threatening pathogens to our society. Biofilm formation and persistent cells within the biofi...