Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children

Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single A...

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Published inNature communications Vol. 10; no. 1; pp. 2288 - 12
Main Authors Li, Yanpeng, Fu, Xuemin, Ma, Jinmin, Zhang, Jianhui, Hu, Yihong, Dong, Wei, Wan, Zhenzhou, Li, Qiongfang, Kuang, Yi-Qun, Lan, Ke, Jin, Xia, Wang, Jian-Hua, Zhang, Chiyu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.05.2019
Nature Publishing Group
Nature Portfolio
Subjects
13/21
45/22
45/23
45/88
49/90
631/250/127
631/326/107
631/326/596/2142
692/699/255/2514
82/79
Acute Disease
Bacteriophages - genetics
Bacteriophages - isolation & purification
Child
Child, Preschool
Children
Cytokines
Cytokines - blood
Cytokines - immunology
Disease Susceptibility - blood
Disease Susceptibility - immunology
Disease Susceptibility - microbiology
Female
High-Throughput Nucleotide Sequencing - methods
Homeostasis
Humanities and Social Sciences
Humans
Infant
Longitudinal Studies
Male
Metagenomics - methods
Microbiota - genetics
multidisciplinary
Phages
Platelet-derived growth factor
Platelet-derived growth factor BB
Population studies
Propionibacterium
Propionibacterium - virology
Proteomics - methods
Recurrence
Relative abundance
Respiratory System - immunology
Respiratory System - virology
Respiratory tract
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - blood
Respiratory Tract Infections - immunology
Respiratory Tract Infections - microbiology
Retrospective Studies
Science
Science (multidisciplinary)
Serum levels
Tissue inhibitor of metalloproteinase 1
Online AccessGet full text

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Abstract Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time. Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of Propionibacterium phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.
AbstractList Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time. Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of Propionibacterium phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.
Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of Propionibacterium phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show that relative abundance of Propionibacterium phages as well as serum levels of TIMP-1 and PDGF-BB are increased in multiple ARTIs compared with single ARTI.
ArticleNumber 2288
Author Li, Yanpeng
Lan, Ke
Ma, Jinmin
Fu, Xuemin
Hu, Yihong
Wang, Jian-Hua
Zhang, Jianhui
Li, Qiongfang
Wan, Zhenzhou
Kuang, Yi-Qun
Jin, Xia
Dong, Wei
Zhang, Chiyu
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31123265$$D View this record in MEDLINE/PubMed
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SSID ssj0000391844
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Snippet Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a...
Here, the authors determine the respiratory virome and serum cytokine profile in children diagnosed with acute respiratory tract infections (ARTI) and show...
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StartPage 2288
SubjectTerms 13/21
45/22
45/23
45/88
49/90
631/250/127
631/326/107
631/326/596/2142
692/699/255/2514
82/79
Acute Disease
Bacteriophages - genetics
Bacteriophages - isolation & purification
Child
Child, Preschool
Children
Cytokines
Cytokines - blood
Cytokines - immunology
Disease Susceptibility - blood
Disease Susceptibility - immunology
Disease Susceptibility - microbiology
Female
High-Throughput Nucleotide Sequencing - methods
Homeostasis
Humanities and Social Sciences
Humans
Infant
Longitudinal Studies
Male
Metagenomics - methods
Microbiota - genetics
multidisciplinary
Phages
Platelet-derived growth factor
Platelet-derived growth factor BB
Population studies
Propionibacterium
Propionibacterium - virology
Proteomics - methods
Recurrence
Relative abundance
Respiratory System - immunology
Respiratory System - virology
Respiratory tract
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - blood
Respiratory Tract Infections - immunology
Respiratory Tract Infections - microbiology
Retrospective Studies
Science
Science (multidisciplinary)
Serum levels
Tissue inhibitor of metalloproteinase 1
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Title Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children
URI https://link.springer.com/article/10.1038/s41467-019-10294-x
https://www.ncbi.nlm.nih.gov/pubmed/31123265
https://www.proquest.com/docview/2229261036
https://www.proquest.com/docview/2231851854
https://pubmed.ncbi.nlm.nih.gov/PMC6533328
https://doaj.org/article/a844a884678c47ab8be737931cdfe8ea
Volume 10
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