Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease

• Published in: Scientific reports Vol. 7; no. 1; pp. 12906 - 11
• Main Authors: Kotliar, Konstantin, Hauser, Christine, Ortner, Marion, Muggenthaler, Claudia, Diehl-Schmid, Janine, Angermann, Susanne, Hapfelmeier, Alexander, Schmaderer, Christoph, Grimmer, Timo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.10.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 692/617; 692/617/375/132/1283; Aged; Alzheimer Disease - complications; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Alzheimer's disease; Biomarkers; Biomarkers - metabolism; Blood vessels; Cardiovascular diseases; Cognitive ability; Cohort Studies; Dementia; Dementia - complications; Dementia - physiopathology; Dementia disorders; Diabetes; Female; Geriatrics; Humanities and Social Sciences; Humans; Hypotheses; Light; Light effects; Magnetic resonance imaging; Male; multidisciplinary; Neuropsychology; Neurovascular Coupling - physiology; Optical Imaging - methods; Patients; Peptides; Psychotropic drugs; Retina; Retinal Vessels - physiopathology; ROC Curve; Science; Science (multidisciplinary); Word of mouth advertising

Neurovascular coupling can be directly assessed by retinal vessel response to flickering light using optical imaging methods. The response is altered in a number of ocular and cardiovascular diseases. Whether it is altered in Alzheimer’s disease (AD) is investigated. Retinal vessel reaction to monoc...