Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell...

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Published inNature communications Vol. 11; no. 1; pp. 524 - 15
Main Authors Mosaheb, Mubeen M., Dobrikova, Elena Y., Brown, Michael C., Yang, Yuanfan, Cable, Jana, Okada, Hideho, Nair, Smita K., Bigner, Darell D., Ashley, David M., Gromeier, Matthias
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.01.2020
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/106
13/109
13/21
13/31
13/51
631/250/251
631/326/596
631/67/1059/4042
631/67/1858
692/4028/67/1922
Adaptive immunity
Animal models
Animals
Antigen (tumor-associated)
Antigen presentation
Antigens
Cancer Vaccines
CD8 antigen
CD8-Positive T-Lymphocytes - physiology
Cell adhesion & migration
Cell migration
Chimeras
Cytokines
Dendritic cells
Dendritic Cells - immunology
Epitopes
Expression vectors
Genetic Vectors - immunology
Genomic instability
Glioblastoma
Glioma - immunology
HEK293 Cells
HeLa Cells
Humanities and Social Sciences
Humans
Immunity
Immunity, Innate
Immunotherapy - methods
Innate immunity
Inoculation
Interferon Type I - immunology
Lymphocytes
Lymphocytes T
Melanoma - immunology
Mice
Mice, Inbred C57BL
multidisciplinary
Oncolysis
Poliovirus - genetics
Poliovirus - immunology
Priming
Science
Science (multidisciplinary)
Survival
Tropism
Tumors
Viruses
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Abstract Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models. Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
AbstractList Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models. Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models.Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models.
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models.
Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-based vector applications. Here we devised a strategy based on the polio:rhinovirus chimera PVSRIPO, devoid of viral neuropathogenicity after intracerebral inoculation in human subjects, for stable expression of exogenous antigens. PVSRIPO vectors infect, activate, and induce epitope presentation in DCs in vitro; they recruit and activate DCs with Th1-dominant cytokine profiles at the injection site in vivo. They efficiently prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site, delay tumor growth and enhance survival in murine tumor models.Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
ArticleNumber 524
Author Yang, Yuanfan
Nair, Smita K.
Gromeier, Matthias
Dobrikova, Elena Y.
Cable, Jana
Bigner, Darell D.
Mosaheb, Mubeen M.
Okada, Hideho
Brown, Michael C.
Ashley, David M.
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Cites_doi 10.1128/MCB.05589-11
10.1038/nature10673
10.1128/JVI.72.6.5056-5060.1998
10.1038/nature18300
10.1128/JVI.00243-06
10.1007/BF03159989
10.4049/jimmunol.171.9.4473
10.1111/j.1600-065X.2009.00784.x
10.1016/j.ccell.2017.04.003
10.1128/JVI.01883-14
10.1016/j.immuni.2015.05.018
10.1084/jem.170.4.1091
10.1007/s00401-016-1545-1
10.1084/jem.20171046
10.1101/cshperspect.a018689
10.1084/jem.20021910
10.1073/pnas.95.14.8216
10.1128/JVI.79.10.6281-6290.2005
10.1016/j.immuni.2014.10.019
10.1146/annurev.immunol.21.120601.141110
10.1073/pnas.88.3.951
10.1128/JVI.80.7.3147-3156.2006
10.1016/j.ccr.2013.12.004
10.1084/jem.20101158
10.1128/JVI.73.11.9485-9495.1999
10.1016/S0042-6822(03)00191-0
10.1038/nature23003
10.1126/science.1164206
10.1128/JVI.75.2.622-627.2001
10.1016/j.jviromet.2008.09.020
10.1126/scitranslmed.aan4220
10.1056/NEJMoa1716435
10.1038/s41467-019-09140-x
10.1038/ncomms5767
10.1038/nri3254
10.1128/JVI.06427-11
10.1056/NEJMoa1504030
10.1002/embj.201386124
10.1073/pnas.93.6.2370
10.1084/jem.191.3.411
10.1073/pnas.0900153106
10.1111/imr.12132
10.1016/j.cell.2017.12.016
10.1128/JVI.75.16.7435-7452.2001
10.1007/BF01323236
10.1038/ni1522
10.1128/JVI.65.11.6194-6204.1991
10.1016/0300-9084(88)90166-6
10.1182/blood-2003-05-1524
10.1038/nri3845
10.1126/science.8073288
10.1097/01.cji.0000436722.46675.4a
10.1038/nature04734
10.1128/JVI.79.1.401-409.2005
10.1128/JVI.76.17.8966-8972.2002
10.1038/nature22991
10.1056/NEJMoa1414428
10.1128/JVI.72.1.20-31.1998
10.1006/viro.1993.1433
10.4049/jimmunol.156.7.2473
10.1002/0471142735.im0732s99
10.1016/S0021-9258(18)33352-0
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References Seyfried, el-Abbadi, Roy (CR41) 1992; 17
Campbell, Lin, Dobrikova, Gromeier (CR28) 2005; 79
Hildner (CR35) 2008; 322
Louis (CR13) 2016; 131
Chheda (CR15) 2018; 215
Desjardins (CR11) 2018; 379
Sahin (CR5) 2017; 547
Curtsinger, Lins, Mescher (CR44) 2003; 197
Zitvogel, Galluzzi, Kepp, Smyth, Kroemer (CR52) 2015; 15
Petersen, Morris, Solheim (CR54) 2003; 171
Yang (CR29) 2009; 155
Mellman, Coukos, Dranoff (CR43) 2011; 480
Lechner (CR40) 2013; 36
Andino (CR16) 1994; 265
Sharpe (CR53) 2009; 229
Crotty (CR17) 1999; 73
Lin (CR27) 2014; 5
Dobrikova (CR10) 2012; 86
Naik (CR33) 2007; 8
Dobrikov, Dobrikova, Shveygert, Gromeier (CR58) 2011; 31
Mueller, Wimmer (CR21) 1998; 72
Shen (CR6) 2017; 91
Martinez-Murillo, Martinez (CR42) 2007; 22
Pestova, Hellen, Wimmer (CR22) 1991; 65
Harutyunyan (CR14) 2019; 10
Steinman, Turley, Mellman, Inaba (CR46) 2000; 191
Helft (CR34) 2015; 42
Merrill, Dobrikova, Gromeier (CR25) 2006; 80
Spranger, Dai, Horton, Gajewski (CR36) 2017; 31
Yang (CR51) 2014; 25
Kato (CR55) 2006; 441
Newberg (CR39) 1996; 156
Krausslich, Nicklin, Lee, Wimmer (CR30) 1988; 70
Eberle, Nguyen, Freistadt (CR32) 1995; 140
Crotty (CR18) 2001; 75
Gromeier, Wimmer (CR38) 1998; 72
Gromeier, Alexander, Wimmer (CR8) 1996; 93
Mandl, Hix, Andino (CR19) 2001; 75
Schwartz (CR45) 2003; 21
Heemskerk (CR60) 2003; 102
Ott (CR3) 2017; 547
Brown (CR9) 2017; 9
Deng (CR48) 2014; 41
Irwin, Heath, Sherman (CR59) 1989; 170
de Breyne, Yu, Unbehaun, Pestova, Hellen (CR62) 2009; 106
Hinrichs, Rosenberg (CR1) 2014; 257
Sweeney, Abaeva, Pestova, Hellen (CR63) 2014; 33
Diamond (CR49) 2011; 208
Dufresne, Dobrikova, Schmidt, Gromeier (CR24) 2002; 76
Joffre, Segura, Savina, Amigorena (CR47) 2012; 12
Kranz (CR50) 2016; 534
Wahid, Cannon, Chow (CR7) 2005; 79
Merrill, Gromeier (CR26) 2006; 80
Freistadt, Fleit, Wimmer (CR31) 1993; 195
Postow (CR4) 2015; 372
CR61
Liu, McEachron, Schwartzentruber, Wu (CR12) 2014; 6
Brown (CR64) 2014; 88
Koike (CR57) 1991; 88
Larkin (CR2) 2015; 373
Etchison, Milburn, Edery, Sonenberg, Hershey (CR37) 1982; 257
Ahmad (CR56) 2018; 172
Mandl, Sigal, Rock, Andino (CR20) 1998; 95
Dobrikova, Florez, Gromeier (CR23) 2003; 311
ZS Chheda (13939_CR15) 2018; 215
MG Lechner (13939_CR40) 2013; 36
RH Schwartz (13939_CR45) 2003; 21
J Helft (13939_CR34) 2015; 42
MH Newberg (13939_CR39) 1996; 156
KE Eberle (13939_CR32) 1995; 140
JL Petersen (13939_CR54) 2003; 171
DN Louis (13939_CR13) 2016; 131
L Shen (13939_CR6) 2017; 91
I Mellman (13939_CR43) 2011; 480
S Koike (13939_CR57) 1991; 88
X Yang (13939_CR29) 2009; 155
MK Merrill (13939_CR25) 2006; 80
MC Brown (13939_CR9) 2017; 9
MS Freistadt (13939_CR31) 1993; 195
SH Naik (13939_CR33) 2007; 8
MS Diamond (13939_CR49) 2011; 208
S Crotty (13939_CR17) 1999; 73
MC Brown (13939_CR64) 2014; 88
S Mandl (13939_CR19) 2001; 75
S Mandl (13939_CR20) 1998; 95
M Dobrikov (13939_CR58) 2011; 31
MA Postow (13939_CR4) 2015; 372
MJ Irwin (13939_CR59) 1989; 170
JM Curtsinger (13939_CR44) 2003; 197
X Liu (13939_CR12) 2014; 6
EY Dobrikova (13939_CR23) 2003; 311
HG Krausslich (13939_CR30) 1988; 70
MH Heemskerk (13939_CR60) 2003; 102
AS Harutyunyan (13939_CR14) 2019; 10
YC Lin (13939_CR27) 2014; 5
S de Breyne (13939_CR62) 2009; 106
S Crotty (13939_CR18) 2001; 75
R Wahid (13939_CR7) 2005; 79
R Andino (13939_CR16) 1994; 265
13939_CR61
MK Merrill (13939_CR26) 2006; 80
TN Seyfried (13939_CR41) 1992; 17
SA Campbell (13939_CR28) 2005; 79
M Gromeier (13939_CR38) 1998; 72
AH Sharpe (13939_CR53) 2009; 229
R Martinez-Murillo (13939_CR42) 2007; 22
K Hildner (13939_CR35) 2008; 322
LM Kranz (13939_CR50) 2016; 534
S Mueller (13939_CR21) 1998; 72
PA Ott (13939_CR3) 2017; 547
TV Pestova (13939_CR22) 1991; 65
D Etchison (13939_CR37) 1982; 257
S Ahmad (13939_CR56) 2018; 172
H Kato (13939_CR55) 2006; 441
EY Dobrikova (13939_CR10) 2012; 86
L Zitvogel (13939_CR52) 2015; 15
TR Sweeney (13939_CR63) 2014; 33
S Spranger (13939_CR36) 2017; 31
J Larkin (13939_CR2) 2015; 373
X Yang (13939_CR51) 2014; 25
AT Dufresne (13939_CR24) 2002; 76
L Deng (13939_CR48) 2014; 41
OP Joffre (13939_CR47) 2012; 12
CS Hinrichs (13939_CR1) 2014; 257
RM Steinman (13939_CR46) 2000; 191
U Sahin (13939_CR5) 2017; 547
M Gromeier (13939_CR8) 1996; 93
A Desjardins (13939_CR11) 2018; 379
References_xml – volume: 31
  start-page: 2947
  year: 2011
  end-page: 2959
  ident: CR58
  article-title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.05589-11
– volume: 480
  start-page: 480
  year: 2011
  end-page: 489
  ident: CR43
  article-title: Cancer immunotherapy comes of age
  publication-title: Nature
  doi: 10.1038/nature10673
– volume: 72
  start-page: 5056
  year: 1998
  end-page: 5060
  ident: CR38
  article-title: Mechanism of injury-provoked poliomyelitis
  publication-title: J. Virol.
  doi: 10.1128/JVI.72.6.5056-5060.1998
– volume: 534
  start-page: 396
  year: 2016
  end-page: 401
  ident: CR50
  article-title: Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
  publication-title: Nature
  doi: 10.1038/nature18300
– volume: 80
  start-page: 6936
  year: 2006
  end-page: 6942
  ident: CR26
  article-title: The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site
  publication-title: J. Virol.
  doi: 10.1128/JVI.00243-06
– volume: 17
  start-page: 147
  year: 1992
  end-page: 167
  ident: CR41
  article-title: Ganglioside distribution in murine neural tumors
  publication-title: Mol. Chem. Neuropathol.
  doi: 10.1007/BF03159989
– volume: 171
  start-page: 4473
  year: 2003
  end-page: 4478
  ident: CR54
  article-title: Virus evasion of MHC class I molecule presentation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.171.9.4473
– volume: 229
  start-page: 5
  year: 2009
  end-page: 11
  ident: CR53
  article-title: Mechanisms of costimulation
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2009.00784.x
– ident: CR61
– volume: 31
  start-page: 711
  year: 2017
  end-page: 723 e714
  ident: CR36
  article-title: Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2017.04.003
– volume: 88
  start-page: 13135
  year: 2014
  end-page: 13148
  ident: CR64
  article-title: Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase
  publication-title: J. Virol.
  doi: 10.1128/JVI.01883-14
– volume: 42
  start-page: 1197
  year: 2015
  end-page: 1211
  ident: CR34
  article-title: GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.05.018
– volume: 170
  start-page: 1091
  year: 1989
  end-page: 1101
  ident: CR59
  article-title: Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.170.4.1091
– volume: 131
  start-page: 803
  year: 2016
  end-page: 820
  ident: CR13
  article-title: The 2016 world health organization classification of tumors of the central nervous system: a summary
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-016-1545-1
– volume: 215
  start-page: 141
  year: 2018
  end-page: 157
  ident: CR15
  article-title: Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20171046
– volume: 6
  start-page: a018689
  year: 2014
  ident: CR12
  article-title: Histone H3 mutations in pediatric brain tumors
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a018689
– volume: 197
  start-page: 1141
  year: 2003
  end-page: 1151
  ident: CR44
  article-title: Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function
  publication-title: J. Exp. Med
  doi: 10.1084/jem.20021910
– volume: 91
  start-page: e02310
  year: 2017
  end-page: e02316
  ident: CR6
  article-title: Pathogenic events in a nonhuman primate model of oral poliovirus infection leading to paralytic poliomyelitis
  publication-title: J. Virol.
– volume: 95
  start-page: 8216
  year: 1998
  end-page: 8221
  ident: CR20
  article-title: Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.14.8216
– volume: 79
  start-page: 6281
  year: 2005
  end-page: 6290
  ident: CR28
  article-title: Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.10.6281-6290.2005
– volume: 41
  start-page: 843
  year: 2014
  end-page: 852
  ident: CR48
  article-title: STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.10.019
– volume: 21
  start-page: 305
  year: 2003
  end-page: 334
  ident: CR45
  article-title: T cell anergy
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.21.120601.141110
– volume: 88
  start-page: 951
  year: 1991
  end-page: 955
  ident: CR57
  article-title: Transgenic mice susceptible to poliovirus
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.88.3.951
– volume: 80
  start-page: 3147
  year: 2006
  end-page: 3156
  ident: CR25
  article-title: Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76
  publication-title: J. Virol.
  doi: 10.1128/JVI.80.7.3147-3156.2006
– volume: 25
  start-page: 37
  year: 2014
  end-page: 48
  ident: CR51
  article-title: Targeting the tumor microenvironment with interferon-beta bridges innate and adaptive immune responses
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.12.004
– volume: 208
  start-page: 1989
  year: 2011
  end-page: 2003
  ident: CR49
  article-title: Type I interferon is selectively required by dendritic cells for immune rejection of tumors
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20101158
– volume: 73
  start-page: 9485
  year: 1999
  end-page: 9495
  ident: CR17
  article-title: Mucosal immunization of cynomolgus macaques with two serotypes of live poliovirus vectors expressing simian immunodeficiency virus antigens: stimulation of humoral, mucosal, and cellular immunity
  publication-title: J. Virol.
  doi: 10.1128/JVI.73.11.9485-9495.1999
– volume: 311
  start-page: 241
  year: 2003
  end-page: 253
  ident: CR23
  article-title: Structural determinants of insert retention of poliovirus expression vectors with recombinant IRES elements
  publication-title: Virology
  doi: 10.1016/S0042-6822(03)00191-0
– volume: 547
  start-page: 222
  year: 2017
  end-page: 226
  ident: CR5
  article-title: Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
  publication-title: Nature
  doi: 10.1038/nature23003
– volume: 322
  start-page: 1097
  year: 2008
  end-page: 1100
  ident: CR35
  article-title: Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity
  publication-title: Science
  doi: 10.1126/science.1164206
– volume: 75
  start-page: 622
  year: 2001
  end-page: 627
  ident: CR19
  article-title: Preexisting immunity to poliovirus does not impair the efficacy of recombinant poliovirus vaccine vectors
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.2.622-627.2001
– volume: 156
  start-page: 2473
  year: 1996
  end-page: 2480
  ident: CR39
  article-title: Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules
  publication-title: J. Immunol.
– volume: 155
  start-page: 44
  year: 2009
  end-page: 54
  ident: CR29
  article-title: Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay
  publication-title: J. Virol. Methods
  doi: 10.1016/j.jviromet.2008.09.020
– volume: 9
  start-page: eaan4220
  year: 2017
  ident: CR9
  article-title: Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aan4220
– volume: 379
  start-page: 150
  year: 2018
  end-page: 161
  ident: CR11
  article-title: Recurrent glioblastoma treated with recombinant poliovirus
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1716435
– volume: 10
  year: 2019
  ident: CR14
  article-title: H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09140-x
– volume: 5
  year: 2014
  ident: CR27
  article-title: Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5767
– volume: 12
  start-page: 557
  year: 2012
  end-page: 569
  ident: CR47
  article-title: Cross-presentation by dendritic cells
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3254
– volume: 22
  start-page: 1309
  year: 2007
  end-page: 1326
  ident: CR42
  article-title: Standardization of an orthotopic mouse brain tumor model following transplantation of CT-2A astrocytoma cells
  publication-title: Histol. Histopathol.
– volume: 86
  start-page: 2750
  year: 2012
  end-page: 2759
  ident: CR10
  article-title: Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in
  publication-title: J. Virol.
  doi: 10.1128/JVI.06427-11
– volume: 373
  start-page: 23
  year: 2015
  end-page: 34
  ident: CR2
  article-title: Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1504030
– volume: 33
  start-page: 76
  year: 2014
  end-page: 92
  ident: CR63
  article-title: The mechanism of translation initiation on Type 1 picornavirus IRESs
  publication-title: EMBO J.
  doi: 10.1002/embj.201386124
– volume: 93
  start-page: 2370
  year: 1996
  end-page: 2375
  ident: CR8
  article-title: Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.6.2370
– volume: 191
  start-page: 411
  year: 2000
  end-page: 416
  ident: CR46
  article-title: The induction of tolerance by dendritic cells that have captured apoptotic cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.3.411
– volume: 106
  start-page: 9197
  year: 2009
  end-page: 9202
  ident: CR62
  article-title: Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0900153106
– volume: 257
  start-page: 56
  year: 2014
  end-page: 71
  ident: CR1
  article-title: Exploiting the curative potential of adoptive T-cell therapy for cancer
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12132
– volume: 172
  start-page: 797
  year: 2018
  end-page: 810 e713
  ident: CR56
  article-title: Breaching self-tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation
  publication-title: Cell
  doi: 10.1016/j.cell.2017.12.016
– volume: 75
  start-page: 7435
  year: 2001
  end-page: 7452
  ident: CR18
  article-title: Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.16.7435-7452.2001
– volume: 140
  start-page: 2135
  year: 1995
  end-page: 2150
  ident: CR32
  article-title: Low levels of poliovirus replication in primary human monocytes: possible interactions with lymphocytes
  publication-title: Arch. Virol.
  doi: 10.1007/BF01323236
– volume: 8
  start-page: 1217
  year: 2007
  end-page: 1226
  ident: CR33
  article-title: Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1522
– volume: 65
  start-page: 6194
  year: 1991
  end-page: 6204
  ident: CR22
  article-title: Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5′ nontranslated region and involvement of a cellular 57-kilodalton protein
  publication-title: J. Virol.
  doi: 10.1128/JVI.65.11.6194-6204.1991
– volume: 70
  start-page: 119
  year: 1988
  end-page: 130
  ident: CR30
  article-title: Polyprotein processing in picornavirus replication
  publication-title: Biochimie
  doi: 10.1016/0300-9084(88)90166-6
– volume: 102
  start-page: 3530
  year: 2003
  end-page: 3540
  ident: CR60
  article-title: Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region
  publication-title: Blood
  doi: 10.1182/blood-2003-05-1524
– volume: 15
  start-page: 405
  year: 2015
  end-page: 414
  ident: CR52
  article-title: Type I interferons in anticancer immunity
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3845
– volume: 265
  start-page: 1448
  year: 1994
  end-page: 1451
  ident: CR16
  article-title: Engineering poliovirus as a vaccine vector for the expression of diverse antigens
  publication-title: Science
  doi: 10.1126/science.8073288
– volume: 36
  start-page: 477
  year: 2013
  end-page: 489
  ident: CR40
  article-title: Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy
  publication-title: J. Immunother.
  doi: 10.1097/01.cji.0000436722.46675.4a
– volume: 441
  start-page: 101
  year: 2006
  end-page: 105
  ident: CR55
  article-title: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
  publication-title: Nature
  doi: 10.1038/nature04734
– volume: 79
  start-page: 401
  year: 2005
  end-page: 409
  ident: CR7
  article-title: Dendritic cells and macrophages are productively infected by poliovirus
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.1.401-409.2005
– volume: 76
  start-page: 8966
  year: 2002
  end-page: 8972
  ident: CR24
  article-title: Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites
  publication-title: J. Virol.
  doi: 10.1128/JVI.76.17.8966-8972.2002
– volume: 547
  start-page: 217
  year: 2017
  end-page: 221
  ident: CR3
  article-title: An immunogenic personal neoantigen vaccine for patients with melanoma
  publication-title: Nature
  doi: 10.1038/nature22991
– volume: 372
  start-page: 2006
  year: 2015
  end-page: 2017
  ident: CR4
  article-title: Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1414428
– volume: 72
  start-page: 20
  year: 1998
  end-page: 31
  ident: CR21
  article-title: Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames
  publication-title: J. Virol.
  doi: 10.1128/JVI.72.1.20-31.1998
– volume: 195
  start-page: 798
  year: 1993
  end-page: 803
  ident: CR31
  article-title: Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication
  publication-title: Virology
  doi: 10.1006/viro.1993.1433
– volume: 257
  start-page: 14806
  year: 1982
  end-page: 14810
  ident: CR37
  article-title: Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex
  publication-title: J. Biol. Chem.
– volume: 86
  start-page: 2750
  year: 2012
  ident: 13939_CR10
  publication-title: J. Virol.
  doi: 10.1128/JVI.06427-11
– volume: 171
  start-page: 4473
  year: 2003
  ident: 13939_CR54
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.171.9.4473
– volume: 547
  start-page: 217
  year: 2017
  ident: 13939_CR3
  publication-title: Nature
  doi: 10.1038/nature22991
– volume: 229
  start-page: 5
  year: 2009
  ident: 13939_CR53
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2009.00784.x
– volume: 534
  start-page: 396
  year: 2016
  ident: 13939_CR50
  publication-title: Nature
  doi: 10.1038/nature18300
– volume: 65
  start-page: 6194
  year: 1991
  ident: 13939_CR22
  publication-title: J. Virol.
  doi: 10.1128/JVI.65.11.6194-6204.1991
– volume: 73
  start-page: 9485
  year: 1999
  ident: 13939_CR17
  publication-title: J. Virol.
  doi: 10.1128/JVI.73.11.9485-9495.1999
– volume: 75
  start-page: 7435
  year: 2001
  ident: 13939_CR18
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.16.7435-7452.2001
– volume: 131
  start-page: 803
  year: 2016
  ident: 13939_CR13
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-016-1545-1
– volume: 79
  start-page: 401
  year: 2005
  ident: 13939_CR7
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.1.401-409.2005
– volume: 9
  start-page: eaan4220
  year: 2017
  ident: 13939_CR9
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aan4220
– volume: 257
  start-page: 56
  year: 2014
  ident: 13939_CR1
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12132
– volume: 88
  start-page: 13135
  year: 2014
  ident: 13939_CR64
  publication-title: J. Virol.
  doi: 10.1128/JVI.01883-14
– volume: 41
  start-page: 843
  year: 2014
  ident: 13939_CR48
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.10.019
– volume: 5
  year: 2014
  ident: 13939_CR27
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5767
– volume: 547
  start-page: 222
  year: 2017
  ident: 13939_CR5
  publication-title: Nature
  doi: 10.1038/nature23003
– volume: 480
  start-page: 480
  year: 2011
  ident: 13939_CR43
  publication-title: Nature
  doi: 10.1038/nature10673
– volume: 15
  start-page: 405
  year: 2015
  ident: 13939_CR52
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3845
– volume: 70
  start-page: 119
  year: 1988
  ident: 13939_CR30
  publication-title: Biochimie
  doi: 10.1016/0300-9084(88)90166-6
– volume: 373
  start-page: 23
  year: 2015
  ident: 13939_CR2
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1504030
– volume: 311
  start-page: 241
  year: 2003
  ident: 13939_CR23
  publication-title: Virology
  doi: 10.1016/S0042-6822(03)00191-0
– volume: 155
  start-page: 44
  year: 2009
  ident: 13939_CR29
  publication-title: J. Virol. Methods
  doi: 10.1016/j.jviromet.2008.09.020
– volume: 75
  start-page: 622
  year: 2001
  ident: 13939_CR19
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.2.622-627.2001
– volume: 372
  start-page: 2006
  year: 2015
  ident: 13939_CR4
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1414428
– volume: 156
  start-page: 2473
  year: 1996
  ident: 13939_CR39
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.156.7.2473
– volume: 33
  start-page: 76
  year: 2014
  ident: 13939_CR63
  publication-title: EMBO J.
  doi: 10.1002/embj.201386124
– volume: 102
  start-page: 3530
  year: 2003
  ident: 13939_CR60
  publication-title: Blood
  doi: 10.1182/blood-2003-05-1524
– volume: 76
  start-page: 8966
  year: 2002
  ident: 13939_CR24
  publication-title: J. Virol.
  doi: 10.1128/JVI.76.17.8966-8972.2002
– volume: 42
  start-page: 1197
  year: 2015
  ident: 13939_CR34
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.05.018
– volume: 80
  start-page: 3147
  year: 2006
  ident: 13939_CR25
  publication-title: J. Virol.
  doi: 10.1128/JVI.80.7.3147-3156.2006
– volume: 36
  start-page: 477
  year: 2013
  ident: 13939_CR40
  publication-title: J. Immunother.
  doi: 10.1097/01.cji.0000436722.46675.4a
– volume: 170
  start-page: 1091
  year: 1989
  ident: 13939_CR59
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.170.4.1091
– volume: 80
  start-page: 6936
  year: 2006
  ident: 13939_CR26
  publication-title: J. Virol.
  doi: 10.1128/JVI.00243-06
– volume: 79
  start-page: 6281
  year: 2005
  ident: 13939_CR28
  publication-title: J. Virol.
  doi: 10.1128/JVI.79.10.6281-6290.2005
– volume: 72
  start-page: 20
  year: 1998
  ident: 13939_CR21
  publication-title: J. Virol.
  doi: 10.1128/JVI.72.1.20-31.1998
– volume: 191
  start-page: 411
  year: 2000
  ident: 13939_CR46
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.191.3.411
– volume: 72
  start-page: 5056
  year: 1998
  ident: 13939_CR38
  publication-title: J. Virol.
  doi: 10.1128/JVI.72.6.5056-5060.1998
– volume: 195
  start-page: 798
  year: 1993
  ident: 13939_CR31
  publication-title: Virology
  doi: 10.1006/viro.1993.1433
– volume: 93
  start-page: 2370
  year: 1996
  ident: 13939_CR8
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.6.2370
– volume: 31
  start-page: 711
  year: 2017
  ident: 13939_CR36
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2017.04.003
– ident: 13939_CR61
  doi: 10.1002/0471142735.im0732s99
– volume: 197
  start-page: 1141
  year: 2003
  ident: 13939_CR44
  publication-title: J. Exp. Med
  doi: 10.1084/jem.20021910
– volume: 257
  start-page: 14806
  year: 1982
  ident: 13939_CR37
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)33352-0
– volume: 17
  start-page: 147
  year: 1992
  ident: 13939_CR41
  publication-title: Mol. Chem. Neuropathol.
  doi: 10.1007/BF03159989
– volume: 91
  start-page: e02310
  year: 2017
  ident: 13939_CR6
  publication-title: J. Virol.
– volume: 95
  start-page: 8216
  year: 1998
  ident: 13939_CR20
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.95.14.8216
– volume: 6
  start-page: a018689
  year: 2014
  ident: 13939_CR12
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a018689
– volume: 8
  start-page: 1217
  year: 2007
  ident: 13939_CR33
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1522
– volume: 106
  start-page: 9197
  year: 2009
  ident: 13939_CR62
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0900153106
– volume: 31
  start-page: 2947
  year: 2011
  ident: 13939_CR58
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.05589-11
– volume: 379
  start-page: 150
  year: 2018
  ident: 13939_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1716435
– volume: 140
  start-page: 2135
  year: 1995
  ident: 13939_CR32
  publication-title: Arch. Virol.
  doi: 10.1007/BF01323236
– volume: 21
  start-page: 305
  year: 2003
  ident: 13939_CR45
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.21.120601.141110
– volume: 25
  start-page: 37
  year: 2014
  ident: 13939_CR51
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.12.004
– volume: 441
  start-page: 101
  year: 2006
  ident: 13939_CR55
  publication-title: Nature
  doi: 10.1038/nature04734
– volume: 172
  start-page: 797
  year: 2018
  ident: 13939_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2017.12.016
– volume: 215
  start-page: 141
  year: 2018
  ident: 13939_CR15
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20171046
– volume: 208
  start-page: 1989
  year: 2011
  ident: 13939_CR49
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20101158
– volume: 322
  start-page: 1097
  year: 2008
  ident: 13939_CR35
  publication-title: Science
  doi: 10.1126/science.1164206
– volume: 22
  start-page: 1309
  year: 2007
  ident: 13939_CR42
  publication-title: Histol. Histopathol.
– volume: 265
  start-page: 1448
  year: 1994
  ident: 13939_CR16
  publication-title: Science
  doi: 10.1126/science.8073288
– volume: 10
  year: 2019
  ident: 13939_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-09140-x
– volume: 88
  start-page: 951
  year: 1991
  ident: 13939_CR57
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.88.3.951
– volume: 12
  start-page: 557
  year: 2012
  ident: 13939_CR47
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3254
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Snippet Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a...
Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to...
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13/31
13/51
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631/326/596
631/67/1059/4042
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692/4028/67/1922
Adaptive immunity
Animal models
Animals
Antigen (tumor-associated)
Antigen presentation
Antigens
Cancer Vaccines
CD8 antigen
CD8-Positive T-Lymphocytes - physiology
Cell adhesion & migration
Cell migration
Chimeras
Cytokines
Dendritic cells
Dendritic Cells - immunology
Epitopes
Expression vectors
Genetic Vectors - immunology
Genomic instability
Glioblastoma
Glioma - immunology
HEK293 Cells
HeLa Cells
Humanities and Social Sciences
Humans
Immunity
Immunity, Innate
Immunotherapy - methods
Innate immunity
Inoculation
Interferon Type I - immunology
Lymphocytes
Lymphocytes T
Melanoma - immunology
Mice
Mice, Inbred C57BL
multidisciplinary
Oncolysis
Poliovirus - genetics
Poliovirus - immunology
Priming
Science
Science (multidisciplinary)
Survival
Tropism
Tumors
Viruses
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Title Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
URI https://link.springer.com/article/10.1038/s41467-019-13939-z
https://www.ncbi.nlm.nih.gov/pubmed/31988324
https://www.proquest.com/docview/2346393465
https://www.proquest.com/docview/2347510356
https://pubmed.ncbi.nlm.nih.gov/PMC6985231
https://doaj.org/article/9ce93ce8bbd34e53a699a9500f6bbbbf
Volume 11
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