OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine

• Published in: Scientific reports Vol. 10; no. 1; p. 5285
• Main Authors: López-Cortés, Andrés, Paz-y-Miño, César, Guerrero, Santiago, Cabrera-Andrade, Alejandro, Barigye, Stephen J., Munteanu, Cristian R., González-Díaz, Humberto, Pazos, Alejandro, Pérez-Castillo, Yunierkis, Tejera, Eduardo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.03.2020; Nature Publishing Group
• Subjects: 38; 631/67/1347; 631/67/69; 692/4017; AKT1 protein; Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Clinical trials; Cyclin-dependent kinase 2; Doxorubicin; Drug development; E-cadherin; Epidermal growth factor receptors; ErbB-2 protein; Female; GATA-3 protein; Gene Expression Regulation, Neoplastic; Gene mapping; Gene Regulatory Networks; Genes, Essential; Grb2 protein; Heterogeneity; High-Throughput Nucleotide Sequencing; Humanities and Social Sciences; Humans; Mice; Monoclonal antibodies; mRNA; multidisciplinary; Mutation; Oncology; p53 Protein; Paclitaxel; Precision Medicine; Prognosis; Protein Interaction Maps; Proteins; Proteome; Rac1 protein; Science; Science (multidisciplinary); Signal transduction; Tamoxifen; Targeted cancer therapy; Therapeutic applications; Trastuzumab; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Xenografts

Breast cancer (BC) is the leading cause of cancer-related death among women and the most commonly diagnosed cancer worldwide. Although in recent years large-scale efforts have focused on identifying new therapeutic targets, a better understanding of BC molecular processes is required. Here we focuse...