PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma

• Published in: Cell death & disease Vol. 13; no. 11; pp. 1010 - 12
• Main Authors: Hu, Xiaomeng, He, Yuchao, Han, Zhiqiang, Liu, Wei, Liu, Dongming, Zhang, Xihao, Chen, Lu, Qi, Lisha, Chen, Liwei, Luo, Yi, Li, Qiang, Chen, Peng, Wu, Qiang, Zhu, Xiaolin, Guo, Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.11.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 13/31; 13/51; 631/67/395; 631/80/82; 64/60; 82/1; Antibodies; Antitumor activity; Autophagy; Autophagy - genetics; Biochemistry; Biomedical and Life Sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell Biology; Cell Culture; Cell death; Cystine; Drug development; Ferroptosis; Ferroptosis - genetics; Glutamic Acid; Glutathione; Hepatocellular carcinoma; Homeostasis; Humans; Immunology; Inhibitor drugs; Life Sciences; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Malignancy; Metabolism; Molecular modelling; RNA-Binding Proteins; Therapeutic applications; Therapeutic targets

Effective strategies for hepatocellular carcinoma, which is the second leading cause of death worldwide, remain limited. A growing body of emerging evidence suggests that ferroptosis activation is a novel promising approach for the treatment of this malignancy. Nevertheless, the potential therapeuti...