Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases

Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients’ disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and hea...

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Published inNature communications Vol. 10; no. 1; pp. 2686 - 14
Main Authors Rubin, Samuel J. S., Bai, Lawrence, Haileselassie, Yeneneh, Garay, Gotzone, Yun, Chohee, Becker, Laren, Streett, Sarah E., Sinha, Sidhartha R., Habtezion, Aida
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.06.2019
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/31
631/250/2520
631/250/256/2515
631/250/347
692/4020/1503/257/1389
692/4020/1503/257/1402
82/58
Adult
Aged
Biopsy
Blood
Blood circulation
Cell Separation
Colonoscopy
Crohn's disease
Cytometry
Digestive system
Disease control
Endoscopy
Female
Flow Cytometry - methods
Gastrointestinal tract
Heterogeneity
Homing
Humanities and Social Sciences
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - pathology
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Intestine
Intestines - immunology
Intestines - pathology
Leukocyte migration
Leukocytes
Leukocytes - immunology
Localization
Male
Mass Spectrometry - methods
Middle Aged
multidisciplinary
Phenotypes
Remission
Science
Science (multidisciplinary)
Signatures
Symptom Flare Up
Ulcerative colitis
Young Adult
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-019-10387-7

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Abstract Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients’ disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and healthcare costs. Diagnosis and monitoring of disease requires invasive procedures, such as endoscopy and tissue biopsy. Here we report signatures of heterogeneity between disease diagnoses and phenotypes. Using mass cytometry, we analyze leukocyte subsets, characterize their function(s), and examine gut-homing molecule expression in blood and intestinal tissue from healthy and/or IBD subjects. Some signatures persist in IBD despite remission, and many signatures are highly represented by leukocytes that express gut trafficking molecules. Moreover, distinct systemic and local immune signatures suggest patterns of cell localization in disease. Our findings highlight the importance of gut tropic leukocytes in circulation and reveal that blood-based immune signatures differentiate clinically relevant subsets of IBD. Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.
AbstractList Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients’ disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and healthcare costs. Diagnosis and monitoring of disease requires invasive procedures, such as endoscopy and tissue biopsy. Here we report signatures of heterogeneity between disease diagnoses and phenotypes. Using mass cytometry, we analyze leukocyte subsets, characterize their function(s), and examine gut-homing molecule expression in blood and intestinal tissue from healthy and/or IBD subjects. Some signatures persist in IBD despite remission, and many signatures are highly represented by leukocytes that express gut trafficking molecules. Moreover, distinct systemic and local immune signatures suggest patterns of cell localization in disease. Our findings highlight the importance of gut tropic leukocytes in circulation and reveal that blood-based immune signatures differentiate clinically relevant subsets of IBD. Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.
Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients' disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and healthcare costs. Diagnosis and monitoring of disease requires invasive procedures, such as endoscopy and tissue biopsy. Here we report signatures of heterogeneity between disease diagnoses and phenotypes. Using mass cytometry, we analyze leukocyte subsets, characterize their function(s), and examine gut-homing molecule expression in blood and intestinal tissue from healthy and/or IBD subjects. Some signatures persist in IBD despite remission, and many signatures are highly represented by leukocytes that express gut trafficking molecules. Moreover, distinct systemic and local immune signatures suggest patterns of cell localization in disease. Our findings highlight the importance of gut tropic leukocytes in circulation and reveal that blood-based immune signatures differentiate clinically relevant subsets of IBD.
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients' disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and healthcare costs. Diagnosis and monitoring of disease requires invasive procedures, such as endoscopy and tissue biopsy. Here we report signatures of heterogeneity between disease diagnoses and phenotypes. Using mass cytometry, we analyze leukocyte subsets, characterize their function(s), and examine gut-homing molecule expression in blood and intestinal tissue from healthy and/or IBD subjects. Some signatures persist in IBD despite remission, and many signatures are highly represented by leukocytes that express gut trafficking molecules. Moreover, distinct systemic and local immune signatures suggest patterns of cell localization in disease. Our findings highlight the importance of gut tropic leukocytes in circulation and reveal that blood-based immune signatures differentiate clinically relevant subsets of IBD.Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations, which determine patients' disease phenotype. Current understanding of phenotype determinants is limited, despite increasing prevalence and healthcare costs. Diagnosis and monitoring of disease requires invasive procedures, such as endoscopy and tissue biopsy. Here we report signatures of heterogeneity between disease diagnoses and phenotypes. Using mass cytometry, we analyze leukocyte subsets, characterize their function(s), and examine gut-homing molecule expression in blood and intestinal tissue from healthy and/or IBD subjects. Some signatures persist in IBD despite remission, and many signatures are highly represented by leukocytes that express gut trafficking molecules. Moreover, distinct systemic and local immune signatures suggest patterns of cell localization in disease. Our findings highlight the importance of gut tropic leukocytes in circulation and reveal that blood-based immune signatures differentiate clinically relevant subsets of IBD.
ArticleNumber 2686
Author Yun, Chohee
Rubin, Samuel J. S.
Sinha, Sidhartha R.
Bai, Lawrence
Habtezion, Aida
Becker, Laren
Streett, Sarah E.
Haileselassie, Yeneneh
Garay, Gotzone
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31217423$$D View this record in MEDLINE/PubMed
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Snippet Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations,...
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each disease is characterized by a diverse set of potential manifestations,...
Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the...
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Adult
Aged
Biopsy
Blood
Blood circulation
Cell Separation
Colonoscopy
Crohn's disease
Cytometry
Digestive system
Disease control
Endoscopy
Female
Flow Cytometry - methods
Gastrointestinal tract
Heterogeneity
Homing
Humanities and Social Sciences
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - pathology
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Intestine
Intestines - immunology
Intestines - pathology
Leukocyte migration
Leukocytes
Leukocytes - immunology
Localization
Male
Mass Spectrometry - methods
Middle Aged
multidisciplinary
Phenotypes
Remission
Science
Science (multidisciplinary)
Signatures
Symptom Flare Up
Ulcerative colitis
Young Adult
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Title Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases
URI https://link.springer.com/article/10.1038/s41467-019-10387-7
https://www.ncbi.nlm.nih.gov/pubmed/31217423
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https://pubmed.ncbi.nlm.nih.gov/PMC6584653
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