Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

• Published in: Molecular cancer Vol. 19; no. 1; pp. 1 - 19
• Main Authors: Deng, Rong, Huang, Jun-Hao, Wang, Yan, Zhou, Li-Huan, Wang, Zi-Feng, Hu, Bing-Xin, Chen, Yu-Hong, Yang, Dong, Mai, Jia, Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Peng, Xiao-Dan, Feng, Gong-Kan, Zhu, Xiao-Feng, Tang, Jun
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 08.08.2020; BioMed Central; BMC
• Subjects: Analysis; BRD4; Breast cancer; Breast carcinoma; Calcineurin; Cancer genetics; Carcinoma; Chromosome 21; Cloning; CRISPR; Datasets; Down syndrome; Down's syndrome; Drug resistance; Enhancers; Epigenetics; Gene expression; Genes; Genome editing; Genomes; Genomics; Immunohistochemistry; Information management; Malignancy; Medical prognosis; Medical research; Metastases; Patients; Phenotypes; Plasmids; RCAN1.4; RUNX3; Runx3 protein; Super-enhancer; Survival analysis; Tumor suppressor genes; Tumors

Background Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhibit a remarkably reduced incidence of breast cancer (BC), moving the search for...