Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium

• Published in: International journal of oral science Vol. 13; no. 1; pp. 43 - 15
• Main Authors: Zhang, Yong, Chen, Jiayao, Fu, Haijun, Kuang, Shuhong, He, Feng, Zhang, Min, Shen, Zongshan, Qin, Wei, Lin, Zhengmei, Huang, Shuheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/532/2074; 631/61/2320; Cell culture; Colitis; Dentistry; Exosomes; Gum disease; Helper cells; Humans; Immune response; Inflammatory bowel disease; Inflammatory bowel diseases; Lymphocytes T; Medicine; Mesenchyme; Oral and Maxillofacial Surgery; Orthopedics; Periodontitis; Periodontitis - therapy; Periodontium; Stem cells; Surgical Orthopedics; T-Lymphocytes, Regulatory; Th17 Cells

Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, have hampered their clinical application. These drawbacks can be largely reduced by replacing the traditional...