Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis - Pai, Shraddha; Li, Peipei; Killinger, Bryan; Marshall, Lee; Jia, Peixin; Liao, Ji; Petronis, Arturas; Szabó, Piroska E.; Labrie, Viviane (Nature communications, 2019)
Keywords: 38/91; 45/23; 59; 631/208/177; 631/208/200; 631/337/100/101; 631/378/1689/1761; 631/378/2583; 64/60; 82/58; Abnormalities; Adult; Aged; Animals; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - pathology; Chromatin; Deoxyribonucleic acid; DNA; DNA Methylation; Dopamine; Dopamine - biosynthesis; Enhancer Elements, Genetic - genetics; Epigenesis, Genetic; Epigenetics; Female; Gene Expression Profiling; Growth factors; Humanities and Social Sciences; Humans; Hydroxylase; Insulin; Insulin-like growth factor II; Insulin-Like Growth Factor II - genetics; Male; Mental disorders; Mice; Mice, Knockout; Middle Aged; multidisciplinary; Neostriatum; Neurons; Neurons - pathology; Pathogenesis; Prefrontal cortex; Prefrontal Cortex - cytology; Prefrontal Cortex - pathology; Proteins; Proteomics; Psychosis; Schizophrenia; Schizophrenia - genetics; Schizophrenia - pathology; Science; Science (multidisciplinary); Synthesis; Transcription; Transcriptome - genetics; Tyrosine; Tyrosine 3-monooxygenase; Tyrosine 3-Monooxygenase - genetics; Tyrosine 3-Monooxygenase - metabolism; Young Adult