Genetic dissection of the glutamatergic neuron system in cerebral cortex

• Published in: Nature (London) Vol. 598; no. 7879; pp. 182 - 187
• Main Authors: Matho, Katherine S., Huilgol, Dhananjay, Galbavy, William, He, Miao, Kim, Gukhan, An, Xu, Lu, Jiangteng, Wu, Priscilla, Di Bella, Daniela J., Shetty, Ashwin S., Palaniswamy, Ramesh, Hatfield, Joshua, Raudales, Ricardo, Narasimhan, Arun, Gamache, Eric, Levine, Jesse M., Tucciarone, Jason, Szelenyi, Eric, Harris, Julie A., Mitra, Partha P., Osten, Pavel, Arlotta, Paola, Huang, Z. Josh
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2021; Nature Publishing Group
• Subjects: 13; 14; 14/1; 14/19; 14/32; 14/35; 14/63; 14/69; 38; 42; 631/378; 631/378/2583; Animals; Cell fate; Cell Lineage - genetics; Cerebral cortex; Cerebral Cortex - cytology; Cerebral Cortex - metabolism; Channels; Cloning; Combinatorial analysis; Embryos; Gene expression; Gene Expression Regulation - genetics; Gene mapping; Glutamatergic transmission; Glutamic Acid - metabolism; Humanities and Social Sciences; Male; Mice; multidisciplinary; Neural stem cells; Neurogenesis; Neurons; Pattern formation; Pyramidal cells; Pyramidal Cells - classification; Pyramidal Cells - cytology; Pyramidal Cells - metabolism; Science; Science (multidisciplinary); Subpopulations; Temporal lobe; Transcription factors; Transcription Factors - metabolism

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams and output channels of the cerebral cortex 1 , 2 , yet all derive from neural progenitors of the embryonic dorsal telencephalon 3 , 4 . Here we establish genetic strategies and tools for dissecting and fate-mappin...