Brain milieu induces early microglial maturation through the BAX-Notch axis

• Published in: Nature communications Vol. 13; no. 1; p. 6117
• Main Authors: Zhao, Fangying, He, Jiangyong, Tang, Jun, Cui, Nianfei, Shi, Yanyan, Li, Zhifan, Liu, Shengnan, Wang, Yazhou, Ma, Ming, Zhao, Congjian, Luo, Lingfei, Li, Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.10.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 14/32; 14/34; 38/1; 38/23; 38/39; 38/47; 38/77; 38/88; 45/41; 631/136/142; 631/208/135; 631/250/2502/248; 631/378/2596/1953; 631/80/86/1999; 64/116; 64/60; 82/1; 96/44; Animals; Apoptosis; bcl-2-Associated X Protein - genetics; Brain; Ca2+/calmodulin-dependent protein kinase II; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP response element-binding protein; Embryogenesis; Humanities and Social Sciences; Maturation; Mice; Microglia; multidisciplinary; Myeloid cells; Neurons; Science; Science (multidisciplinary); Signaling; Zebrafish

Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the mechanism by which the brain milieu confers microglial maturation signature remains elusive. Here, we demonstrate that the bax cq55 zebrafish and Bax tm1Sjk mouse embryos exhibit si...