Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

• Published in: The Journal of neuroscience Vol. 15; no. 4; pp. 2888 - 2905
• Main Authors: Li, Y, Holtzman, DM, Kromer, LF, Kaplan, DR, Chua-Couzens, J, Clary, DO, Knusel, B, Mobley, WC
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 01.04.1995; Society for Neuroscience
• Subjects: Aging - metabolism; Animals; Blotting, Northern; Choline O-Acetyltransferase - biosynthesis; Gene Expression Regulation; Hippocampus - metabolism; Immunohistochemistry; In Situ Hybridization; Nerve Growth Factors - pharmacology; Phosphotyrosine; Prosencephalon - growth & development; Prosencephalon - metabolism; Proto-Oncogene Proteins - biosynthesis; Proto-Oncogene Proteins - metabolism; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases - biosynthesis; Receptor Protein-Tyrosine Kinases - metabolism; Receptor, trkA; Receptors, Nerve Growth Factor - biosynthesis; Receptors, Nerve Growth Factor - metabolism; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; Tyrosine - analogs & derivatives; Tyrosine - metabolism

TrkA is a receptor tyrosine kinase whose activation transduces NGF signaling. TrkA expression has been demonstrated in NGF-responsive adult basal forebrain cholinergic neurons (BFCNs). Several lines of evidence have suggested that endogenous NGF plays a role in the development and differentiation of...