Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel

• Published in: Clinical pharmacokinetics Vol. 54; no. 2; pp. 147 - 166
• Main Authors: Jiang, Xi-Ling, Samant, Snehal, Lesko, Lawrence J., Schmidt, Stephan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2015; Springer Nature B.V
• Subjects: Acute Coronary Syndrome - drug therapy; Acute Coronary Syndrome - metabolism; Cytochrome P-450 CYP2C19 - genetics; Cytochrome P-450 CYP2C19 - metabolism; Dose-Response Relationship, Drug; Humans; Internal Medicine; Medicine; Medicine & Public Health; Pharmacology/Toxicology; Pharmacotherapy; Polymorphism, Genetic; Precision Medicine; Purinergic P2Y Receptor Antagonists - pharmacokinetics; Purinergic P2Y Receptor Antagonists - pharmacology; Review Article; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Ticlopidine - pharmacology; Acute Coronary Syndrome Patient; Clopidogrel; Constitutive Androstane Receptor; Clopidogrel Therapy; Percutaneous Coronary Intervention

Acute coronary syndromes (ACS) remain life-threatening disorders, which are associated with high morbidity and mortality. Dual antiplatelet therapy with aspirin and clopidogrel has been shown to reduce cardiovascular events in patients with ACS. However, there is substantial inter-individual variabi...