Comparing DNA enrichment of proliferating cells following administration of different stable isotopes of heavy water

Deuterated water ( 2 H 2 O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enr...

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Published inScientific reports Vol. 7; no. 1; pp. 4043 - 12
Main Authors Farthing, Don E., Buxbaum, Nataliya P., Lucas, Philip J., Maglakelidze, Natella, Oliver, Brittany, Wang, Jiun, Hu, Kevin, Castro, Ehydel, Bare, Catherine V., Gress, Ronald E.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 22.06.2017
Nature Publishing Group
Nature Portfolio
Subjects
13/106
13/31
631/1647/2196/1379
631/67/70
631/92/147
639/638/11/296
64/60
692/308/575
82/16
82/56
Animals
Body water
Bone marrow
Cell growth
Cell Line, Tumor
Cell Proliferation
Deoxyadenosine
Deoxyribonucleic acid
Deuterium
Deuterium Oxide - pharmacology
DNA
DNA - chemistry
DNA - genetics
DNA Replication - drug effects
Headspace
Heavy water
Humanities and Social Sciences
Ionization
Isotope Labeling
Isotopes
Kinases
Mass Spectrometry
Mice
multidisciplinary
Quantitation
Radioactive labeling
Science
Science (multidisciplinary)
Stable isotopes
Thymus
Water levels
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Abstract Deuterated water ( 2 H 2 O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enrichment differences into the DNA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well as tumor cell proliferation effects for various forms of commercially available stable heavy water ( 2 H 2 O, H 2 18 O, and 2 H 2 18 O). Using an in vitro mouse thymus tumor cell line, we determined that H 2 18 O provides superior DNA labeling enrichment quantitation, as measured by GC-positive chemical ionization (PCI)-MS/MS. In addition, at higher but physiologically relevant doses, both 2 H 2 18 O and 2 H 2 O down modulated mouse thymus tumor cell proliferation, whereas H 2 18 O water had no observable effects on cell proliferation. The in vivo labeling studies, where normal mouse bone marrow cells (i.e. high turnover) were evaluated post labeling, demonstrated DNA enrichments concordant with measurements from the in vitro studies. Our research also reports a headspace-GC-NCI-MS method, which rapidly and quantitatively measures stable heavy water levels in total body water.
AbstractList Deuterated water ( H O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enrichment differences into the DNA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well as tumor cell proliferation effects for various forms of commercially available stable heavy water ( H O, H O, and H O). Using an in vitro mouse thymus tumor cell line, we determined that H O provides superior DNA labeling enrichment quantitation, as measured by GC-positive chemical ionization (PCI)-MS/MS. In addition, at higher but physiologically relevant doses, both H O and H O down modulated mouse thymus tumor cell proliferation, whereas H O water had no observable effects on cell proliferation. The in vivo labeling studies, where normal mouse bone marrow cells (i.e. high turnover) were evaluated post labeling, demonstrated DNA enrichments concordant with measurements from the in vitro studies. Our research also reports a headspace-GC-NCI-MS method, which rapidly and quantitatively measures stable heavy water levels in total body water.
Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enrichment differences into the DNA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well as tumor cell proliferation effects for various forms of commercially available stable heavy water (2H2O, H218O, and 2H218O). Using an in vitro mouse thymus tumor cell line, we determined that H218O provides superior DNA labeling enrichment quantitation, as measured by GC-positive chemical ionization (PCI)-MS/MS. In addition, at higher but physiologically relevant doses, both 2H218O and 2H2O down modulated mouse thymus tumor cell proliferation, whereas H218O water had no observable effects on cell proliferation. The in vivo labeling studies, where normal mouse bone marrow cells (i.e. high turnover) were evaluated post labeling, demonstrated DNA enrichments concordant with measurements from the in vitro studies. Our research also reports a headspace-GC-NCI-MS method, which rapidly and quantitatively measures stable heavy water levels in total body water.
Deuterated water ( 2 H 2 O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enrichment differences into the DNA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well as tumor cell proliferation effects for various forms of commercially available stable heavy water ( 2 H 2 O, H 2 18 O, and 2 H 2 18 O). Using an in vitro mouse thymus tumor cell line, we determined that H 2 18 O provides superior DNA labeling enrichment quantitation, as measured by GC-positive chemical ionization (PCI)-MS/MS. In addition, at higher but physiologically relevant doses, both 2 H 2 18 O and 2 H 2 O down modulated mouse thymus tumor cell proliferation, whereas H 2 18 O water had no observable effects on cell proliferation. The in vivo labeling studies, where normal mouse bone marrow cells (i.e. high turnover) were evaluated post labeling, demonstrated DNA enrichments concordant with measurements from the in vitro studies. Our research also reports a headspace-GC-NCI-MS method, which rapidly and quantitatively measures stable heavy water levels in total body water.
Abstract Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and other biomolecules. Our in vitro - in vivo research reports important stable isotopic labeling enrichment differences into the DNA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well as tumor cell proliferation effects for various forms of commercially available stable heavy water (2H2O, H2 18O, and 2H2 18O). Using an in vitro mouse thymus tumor cell line, we determined that H2 18O provides superior DNA labeling enrichment quantitation, as measured by GC-positive chemical ionization (PCI)-MS/MS. In addition, at higher but physiologically relevant doses, both 2H2 18O and 2H2O down modulated mouse thymus tumor cell proliferation, whereas H2 18O water had no observable effects on cell proliferation. The in vivo labeling studies, where normal mouse bone marrow cells (i.e. high turnover) were evaluated post labeling, demonstrated DNA enrichments concordant with measurements from the in vitro studies. Our research also reports a headspace-GC-NCI-MS method, which rapidly and quantitatively measures stable heavy water levels in total body water.
ArticleNumber 4043
Author Bare, Catherine V.
Gress, Ronald E.
Hu, Kevin
Buxbaum, Nataliya P.
Lucas, Philip J.
Farthing, Don E.
Maglakelidze, Natella
Oliver, Brittany
Wang, Jiun
Castro, Ehydel
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/28642474$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nri2037
10.1016/j.ab.2011.09.007
10.1002/jms.3593
10.1073/pnas.232551499
10.1139/y99-005
10.1002/(SICI)1096-9888(199606)31:6<639::AID-JMS336>3.0.CO;2-S
10.1152/japplphysiol.00691.2002
10.1016/S0167-5699(99)01529-7
10.1172/JCI23409
10.1021/pr8009879
10.1111/j.1365-2141.2010.08334.x
10.1016/j.ymben.2003.09.003
10.1006/abio.1997.2068
10.1038/nprot.2009.117
10.1172/JCI35834
10.1016/S0026-0495(96)90152-3
10.1016/j.ab.2008.04.042
10.1016/j.ab.2010.05.010
10.1152/ajprenal.00295.2003
10.1038/nprot.2007.421
10.1006/abio.2002.5720
10.1006/abio.2001.5375
10.1021/pr025572s
10.1074/jbc.M409660200
10.1073/pnas.95.2.708
10.2527/2006.8413_supplE94x
10.1016/j.ab.2010.04.018
10.1016/j.jim.2008.05.014
10.1111/cei.12064
10.1088/0967-3334/22/4/301
10.1038/nprot.2007.420
10.1006/abio.1998.2632
10.1021/ac030186v
10.1021/ac400309d
10.1002/prca.201400038
10.1182/blood-2003-01-0139
10.1093/ajcn/68.4.932S
10.1093/ajcn/41.2.363
10.1093/ajcn/33.12.2686
10.1242/jcs.98.4.463
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References Vukmanovic-Stejic (CR13) 2008; 118
Fox (CR3) 2003; 75
Farthing (CR10) 2013; 85
Fanara (CR31) 2004; 279
Wang (CR18) 2014; 8
Busch, Neese, Awada, Hayes, Hellerstein (CR2) 2007; 2
Busch, Siah, Gee, Hellerstein (CR35) 2008; 337
Messmer (CR15) 2005; 115
Cabral (CR25) 2008; 379
Schwartz (CR8) 2003; 102
Akbar, Vukmanovic-Stejic, Taams, Macallan (CR12) 2007; 7
Kushner, Baker, Dunstall (CR29) 1999; 77
Yao, Afonso, Fenselau (CR21) 2003; 2
Diraison, Pachiaudi, Beylot (CR26) 1996; 45
De Riva, Deery, McDonald, Lund, Busch (CR16) 2010; 403
Collins, Eng, Hoh, Hellerstein (CR38) 2003; 94
Lukaski, Johnson (CR30) 1985; 41
Raman (CR43) 2004; 286
Katz, Crespi, Hasterlik, Thomson, Finkel (CR41) 1957; 18
Bollyky (CR11) 2013; 172
Neese (CR7) 2001; 298
Defoiche, Zhang, Lagneaux, Willems, Macallan (CR14) 2010; 151
Macallan (CR4) 2009; 4
Price (CR17) 2012; 420
McCabe, Previs (CR23) 2004; 6
Schoeller (CR27) 1980; 33
Lamprecht, Schroeter, Paweletz (CR40) 1991; 98
Previs (CR33) 1996; 31
Hazey (CR24) 1997; 248
Brunengraber, McCabe, Katanik, Previs (CR28) 2002; 306
Walker, Thaden, Deutz (CR39) 2015; 50
Fenselau, Yao (CR19) 2009; 8
Neese (CR6) 2002; 99
Speakman (CR22) 1998; 68
Hellerstein (CR1) 1999; 20
CR42
Murphy (CR20) 2006; 84
Shah, Herath, Previs, Hubbard, Roddy (CR37) 2010; 404
Voogt (CR9) 2007; 2
Macallan (CR5) 1998; 95
Yang (CR34) 1998; 258
Davies, Spanel, Smith (CR32) 2001; 22
Bollyky (CR36) 2013; 172
J Defoiche (4404_CR14) 2010; 151
D Yang (4404_CR34) 1998; 258
C Fenselau (4404_CR19) 2009; 8
JN Voogt (4404_CR9) 2007; 2
CB Cabral (4404_CR25) 2008; 379
R Busch (4404_CR35) 2008; 337
GN Schwartz (4404_CR8) 2003; 102
BT Messmer (4404_CR15) 2005; 115
D Wang (4404_CR18) 2014; 8
DE Farthing (4404_CR10) 2013; 85
DC Macallan (4404_CR4) 2009; 4
DZ Brunengraber (4404_CR28) 2002; 306
JR Speakman (4404_CR22) 1998; 68
JJ Katz (4404_CR41) 1957; 18
RA Neese (4404_CR6) 2002; 99
BJ McCabe (4404_CR23) 2004; 6
JC Price (4404_CR17) 2012; 420
RA Neese (4404_CR7) 2001; 298
JB Bollyky (4404_CR11) 2013; 172
A De Riva (4404_CR16) 2010; 403
P Fanara (4404_CR31) 2004; 279
ML Collins (4404_CR38) 2003; 94
DJ Kushner (4404_CR29) 1999; 77
R Busch (4404_CR2) 2007; 2
A Raman (4404_CR43) 2004; 286
AN Akbar (4404_CR12) 2007; 7
JW Hazey (4404_CR24) 1997; 248
DA Schoeller (4404_CR27) 1980; 33
J Lamprecht (4404_CR40) 1991; 98
4404_CR42
SD Fox (4404_CR3) 2003; 75
S Davies (4404_CR32) 2001; 22
X Yao (4404_CR21) 2003; 2
M Vukmanovic-Stejic (4404_CR13) 2008; 118
V Shah (4404_CR37) 2010; 404
F Diraison (4404_CR26) 1996; 45
HC Lukaski (4404_CR30) 1985; 41
EJ Murphy (4404_CR20) 2006; 84
SF Previs (4404_CR33) 1996; 31
MK Hellerstein (4404_CR1) 1999; 20
DC Macallan (4404_CR5) 1998; 95
JB Bollyky (4404_CR36) 2013; 172
DK Walker (4404_CR39) 2015; 50
References_xml – volume: 7
  start-page: 231
  year: 2007
  end-page: 237
  ident: CR12
  article-title: The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
  publication-title: Nature Reviews Immunology.
  doi: 10.1038/nri2037
  contributor:
    fullname: Macallan
– volume: 420
  start-page: 73
  year: 2012
  end-page: 83
  ident: CR17
  article-title: Measurement of human plasma proteome dynamics with H O and liquid chromatography tandem mass spectrometry
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2011.09.007
  contributor:
    fullname: Price
– volume: 50
  start-page: 838
  year: 2015
  end-page: 843
  ident: CR39
  article-title: Applications of gas chromatography-tandem spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water
  publication-title: J. Mass Spectrometry.
  doi: 10.1002/jms.3593
  contributor:
    fullname: Deutz
– volume: 99
  start-page: 15345
  year: 2002
  end-page: 15350
  ident: CR6
  article-title: Measurement of proliferation rates of slow turnover cells by H O labeling of the deoxyribose moiety of DNA
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.232551499
  contributor:
    fullname: Neese
– volume: 77
  start-page: 79
  issue: 2
  year: 1999
  end-page: 88
  ident: CR29
  article-title: Phamacological uses and perspectives of heavy water and deuterated compounds
  publication-title: Can. J. Physiol Pharmacol.
  doi: 10.1139/y99-005
  contributor:
    fullname: Dunstall
– volume: 31
  start-page: 639
  year: 1996
  end-page: 642
  ident: CR33
  article-title: Assay of the deuterium enrichment of water via acetylene
  publication-title: J. of Mass Spectrometry.
  doi: 10.1002/(SICI)1096-9888(199606)31:6<639::AID-JMS336>3.0.CO;2-S
  contributor:
    fullname: Previs
– volume: 94
  start-page: 2203
  year: 2003
  end-page: 2211
  ident: CR38
  article-title: Measurement of mitochondrial DNA synthesis using a stable isotope-mass spectrometric technique
  publication-title: Journal of Applied Physiology.
  doi: 10.1152/japplphysiol.00691.2002
  contributor:
    fullname: Hellerstein
– volume: 20
  start-page: 438
  year: 1999
  end-page: 441
  ident: CR1
  article-title: Measurement of T-cell kinetics: recent methodologic advances
  publication-title: Trends Immunology Today.
  doi: 10.1016/S0167-5699(99)01529-7
  contributor:
    fullname: Hellerstein
– volume: 115
  start-page: 755
  year: 2005
  end-page: 764
  ident: CR15
  article-title: measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
  publication-title: The Journal of Clinical Investigations.
  doi: 10.1172/JCI23409
  contributor:
    fullname: Messmer
– volume: 8
  start-page: 2140
  year: 2009
  end-page: 2143
  ident: CR19
  article-title: O -Labeling in quantitative proteomic strategies: A status report
  publication-title: Journal of Proteome Research.
  doi: 10.1021/pr8009879
  contributor:
    fullname: Yao
– volume: 68
  start-page: 932S
  year: 1998
  end-page: 938S
  ident: CR22
  article-title: The history and theory of the doubly labeled water technique
  publication-title: Am. J. Clin. Nutr.
  contributor:
    fullname: Speakman
– volume: 151
  start-page: 189
  year: 2010
  end-page: 206
  ident: CR14
  article-title: ribosomal RNA turnover is down-regulated in leukaemic cells in chronic lymphocytic leukaemia
  publication-title: British Journal of Haematology.
  doi: 10.1111/j.1365-2141.2010.08334.x
  contributor:
    fullname: Macallan
– volume: 6
  start-page: 25
  year: 2004
  end-page: 35
  ident: CR23
  article-title: Using isotope tracers to study metabolism: application in mouse models
  publication-title: Metabolic Engineering.
  doi: 10.1016/j.ymben.2003.09.003
  contributor:
    fullname: Previs
– volume: 248
  start-page: 158
  year: 1997
  end-page: 167
  ident: CR24
  article-title: Tracing gluconeogenesis with deuterated water: Measurement of low deuterium enrichments on carbons 6 and 2 of glucose
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.1997.2068
  contributor:
    fullname: Hazey
– volume: 33
  start-page: 2686
  year: 1980
  end-page: 2693
  ident: CR27
  article-title: Total body water measurement in humans with O and H labeled water
  publication-title: American Journal of Clinical Nutrition.
  contributor:
    fullname: Schoeller
– volume: 18
  start-page: 641
  issue: 5
  year: 1957
  end-page: 659
  ident: CR41
  article-title: Some observations on biological effects of deuterium, with special reference to effects on neoplastic processes
  publication-title: J. of the National Cancer Institute
  contributor:
    fullname: Finkel
– volume: 4
  start-page: 1313
  year: 2009
  end-page: 1327
  ident: CR4
  article-title: Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2009.117
  contributor:
    fullname: Macallan
– ident: CR42
– volume: 118
  start-page: 3639
  year: 2008
  end-page: 3650
  ident: CR13
  article-title: The kinetics of CD4+ Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response
  publication-title: The Journal of Clinical Investigations.
  doi: 10.1172/JCI35834
  contributor:
    fullname: Vukmanovic-Stejic
– volume: 45
  start-page: 817
  year: 1996
  end-page: 821
  ident: CR26
  article-title: measurement of plasma cholesterol and fatty acid synthesis with deuterated water: Determinatinon of the average number of deuterium atoms incorporated
  publication-title: Metabolism.
  doi: 10.1016/S0026-0495(96)90152-3
  contributor:
    fullname: Beylot
– volume: 379
  start-page: 40
  year: 2008
  end-page: 44
  ident: CR25
  article-title: Estimating glutathione synthesis with deuterated water: A model for peptide biosynthesis
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2008.04.042
  contributor:
    fullname: Cabral
– volume: 41
  start-page: 363
  year: 1985
  end-page: 370
  ident: CR30
  article-title: A simple, inexpensive method of determining total body water using a tracer dose of D O and infrared absorption of biological fluids
  publication-title: The American Journal of Clinical Nutrition.
  contributor:
    fullname: Johnson
– volume: 404
  start-page: 235
  year: 2010
  end-page: 237
  ident: CR37
  article-title: Headspace analyses of acetone: A rapid method for measuring the H-labeling of water
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2010.05.010
  contributor:
    fullname: Roddy
– volume: 286
  start-page: F394
  year: 2004
  end-page: F401
  ident: CR43
  article-title: Water turnover in 458 American adults 40–79 yr of age
  publication-title: Am J. Physiol Renal Physiol
  doi: 10.1152/ajprenal.00295.2003
  contributor:
    fullname: Raman
– volume: 2
  start-page: 3058
  year: 2007
  end-page: 3062
  ident: CR9
  article-title: Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2007.421
  contributor:
    fullname: Voogt
– volume: 306
  start-page: 278
  year: 2002
  end-page: 282
  ident: CR28
  article-title: Gas chromatography-mass spectrometry assay of the O enrichment of water as trimethyl phosphate
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.2002.5720
  contributor:
    fullname: Previs
– volume: 298
  start-page: 189
  year: 2001
  end-page: 195
  ident: CR7
  article-title: Advances in the stable isotope-mass spectrometric measurement of DNA synthesis and cell proliferation
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.2001.5375
  contributor:
    fullname: Neese
– volume: 2
  start-page: 147
  year: 2003
  end-page: 152
  ident: CR21
  article-title: Dissection of proteolytic O labeling: endoprotease-catalyzed O to O exchange of truncated peptide substrates
  publication-title: Journal of Proteome Research.
  doi: 10.1021/pr025572s
  contributor:
    fullname: Fenselau
– volume: 279
  start-page: 49940
  year: 2004
  end-page: 49947
  ident: CR31
  article-title: measurement of microtubule dynamics using stable isotope labeling with heavy water
  publication-title: J. of Bio. Chem.
  doi: 10.1074/jbc.M409660200
  contributor:
    fullname: Fanara
– volume: 95
  start-page: 708
  year: 1998
  end-page: 713
  ident: CR5
  article-title: Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: Studies , in animals, and in humans
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.2.708
  contributor:
    fullname: Macallan
– volume: 84
  start-page: E94
  year: 2006
  end-page: E104
  ident: CR20
  article-title: Stable isotope methods for the measurement of lipogenesis and triglyceride metabolism
  publication-title: J. Anim. Sci.
  doi: 10.2527/2006.8413_supplE94x
  contributor:
    fullname: Murphy
– volume: 403
  start-page: 1
  year: 2010
  end-page: 12
  ident: CR16
  article-title: Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2010.04.018
  contributor:
    fullname: Busch
– volume: 337
  start-page: 24
  year: 2008
  end-page: 34
  ident: CR35
  article-title: Heavy water labeling of DNA for measurement of cell proliferation and recruitment during primary murine lymph node responses against model antigens
  publication-title: Journal of Immunological Methods.
  doi: 10.1016/j.jim.2008.05.014
  contributor:
    fullname: Hellerstein
– volume: 98
  start-page: 463
  year: 1991
  end-page: 473
  ident: CR40
  article-title: Derangement of microtubule arrays in interphase and mitotic PtK2 cells treated with deuterium oxide (heavy water)
  publication-title: J. of Cell Science
  contributor:
    fullname: Paweletz
– volume: 172
  start-page: 363
  year: 2013
  end-page: 374
  ident: CR36
  article-title: Evaluation of T cell kinetics: use of heavy isotope labelling in type 1 diabetes
  publication-title: Clinical and Experimental Immunology.
  doi: 10.1111/cei.12064
  contributor:
    fullname: Bollyky
– volume: 172
  start-page: 363
  year: 2013
  end-page: 374
  ident: CR11
  article-title: Evaluation of T cell kinetics: use of heavy isotope labelling in type I diabetes
  publication-title: Clinical and Experimental Immunology.
  doi: 10.1111/cei.12064
  contributor:
    fullname: Bollyky
– volume: 22
  start-page: 651
  year: 2001
  end-page: 659
  ident: CR32
  article-title: Rapid measurement of deuterium content of breath following oral ingestion to determine body water
  publication-title: Physiological Measurement.
  doi: 10.1088/0967-3334/22/4/301
  contributor:
    fullname: Smith
– volume: 2
  start-page: 3045
  year: 2007
  end-page: 3057
  ident: CR2
  article-title: Measurement of cell proliferation by heavy water labeling
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2007.420
  contributor:
    fullname: Hellerstein
– volume: 258
  start-page: 315
  year: 1998
  end-page: 321
  ident: CR34
  article-title: Assay of low deuterium enrichment of water by isotopic exchange with [U- C ]-acetone and gas chromatography-mass spectrometry
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.1998.2632
  contributor:
    fullname: Yang
– volume: 75
  start-page: 6517
  year: 2003
  end-page: 6522
  ident: CR3
  article-title: A Comparison of μLC/Electrospray Ionization-MS and GC/MS for the Measurement of Stable Isotope Enrichment from a [ H ]-Glucose Metabolic Probe in T-Cell Genomic DNA
  publication-title: Analytical Chemistry.
  doi: 10.1021/ac030186v
  contributor:
    fullname: Fox
– volume: 85
  start-page: 4613
  year: 2013
  end-page: 4620
  ident: CR10
  article-title: Sensitive GC-MS/MS method to measure deuterium labeled deoxyadenosine in DNA from limited mouse cell populations
  publication-title: Analytical Chemistry.
  doi: 10.1021/ac400309d
  contributor:
    fullname: Farthing
– volume: 8
  start-page: 610
  year: 2014
  end-page: 619
  ident: CR18
  article-title: Characterization of human plasma proteome dynamics using deuterium oxide
  publication-title: Proteomics Clin. Appl.
  doi: 10.1002/prca.201400038
  contributor:
    fullname: Wang
– volume: 102
  start-page: 2068
  year: 2003
  end-page: 2073
  ident: CR8
  article-title: Proliferation kinetics of subpopulations of human marrow cells determined by quantifying incorporation of [2H2]-glucose into DNA of S-phase cells
  publication-title: Blood.
  doi: 10.1182/blood-2003-01-0139
  contributor:
    fullname: Schwartz
– volume: 20
  start-page: 438
  year: 1999
  ident: 4404_CR1
  publication-title: Trends Immunology Today.
  doi: 10.1016/S0167-5699(99)01529-7
  contributor:
    fullname: MK Hellerstein
– volume: 306
  start-page: 278
  year: 2002
  ident: 4404_CR28
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.2002.5720
  contributor:
    fullname: DZ Brunengraber
– ident: 4404_CR42
– volume: 8
  start-page: 610
  year: 2014
  ident: 4404_CR18
  publication-title: Proteomics Clin. Appl.
  doi: 10.1002/prca.201400038
  contributor:
    fullname: D Wang
– volume: 404
  start-page: 235
  year: 2010
  ident: 4404_CR37
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2010.05.010
  contributor:
    fullname: V Shah
– volume: 77
  start-page: 79
  issue: 2
  year: 1999
  ident: 4404_CR29
  publication-title: Can. J. Physiol Pharmacol.
  doi: 10.1139/y99-005
  contributor:
    fullname: DJ Kushner
– volume: 22
  start-page: 651
  year: 2001
  ident: 4404_CR32
  publication-title: Physiological Measurement.
  doi: 10.1088/0967-3334/22/4/301
  contributor:
    fullname: S Davies
– volume: 151
  start-page: 189
  year: 2010
  ident: 4404_CR14
  publication-title: British Journal of Haematology.
  doi: 10.1111/j.1365-2141.2010.08334.x
  contributor:
    fullname: J Defoiche
– volume: 420
  start-page: 73
  year: 2012
  ident: 4404_CR17
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2011.09.007
  contributor:
    fullname: JC Price
– volume: 337
  start-page: 24
  year: 2008
  ident: 4404_CR35
  publication-title: Journal of Immunological Methods.
  doi: 10.1016/j.jim.2008.05.014
  contributor:
    fullname: R Busch
– volume: 286
  start-page: F394
  year: 2004
  ident: 4404_CR43
  publication-title: Am J. Physiol Renal Physiol
  doi: 10.1152/ajprenal.00295.2003
  contributor:
    fullname: A Raman
– volume: 4
  start-page: 1313
  year: 2009
  ident: 4404_CR4
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2009.117
  contributor:
    fullname: DC Macallan
– volume: 403
  start-page: 1
  year: 2010
  ident: 4404_CR16
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2010.04.018
  contributor:
    fullname: A De Riva
– volume: 68
  start-page: 932S
  year: 1998
  ident: 4404_CR22
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/68.4.932S
  contributor:
    fullname: JR Speakman
– volume: 379
  start-page: 40
  year: 2008
  ident: 4404_CR25
  publication-title: Analytical Biochemistry.
  doi: 10.1016/j.ab.2008.04.042
  contributor:
    fullname: CB Cabral
– volume: 279
  start-page: 49940
  year: 2004
  ident: 4404_CR31
  publication-title: J. of Bio. Chem.
  doi: 10.1074/jbc.M409660200
  contributor:
    fullname: P Fanara
– volume: 18
  start-page: 641
  issue: 5
  year: 1957
  ident: 4404_CR41
  publication-title: J. of the National Cancer Institute
  contributor:
    fullname: JJ Katz
– volume: 6
  start-page: 25
  year: 2004
  ident: 4404_CR23
  publication-title: Metabolic Engineering.
  doi: 10.1016/j.ymben.2003.09.003
  contributor:
    fullname: BJ McCabe
– volume: 45
  start-page: 817
  year: 1996
  ident: 4404_CR26
  publication-title: Metabolism.
  doi: 10.1016/S0026-0495(96)90152-3
  contributor:
    fullname: F Diraison
– volume: 118
  start-page: 3639
  year: 2008
  ident: 4404_CR13
  publication-title: The Journal of Clinical Investigations.
  doi: 10.1172/JCI35834
  contributor:
    fullname: M Vukmanovic-Stejic
– volume: 172
  start-page: 363
  year: 2013
  ident: 4404_CR11
  publication-title: Clinical and Experimental Immunology.
  doi: 10.1111/cei.12064
  contributor:
    fullname: JB Bollyky
– volume: 258
  start-page: 315
  year: 1998
  ident: 4404_CR34
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.1998.2632
  contributor:
    fullname: D Yang
– volume: 248
  start-page: 158
  year: 1997
  ident: 4404_CR24
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.1997.2068
  contributor:
    fullname: JW Hazey
– volume: 115
  start-page: 755
  year: 2005
  ident: 4404_CR15
  publication-title: The Journal of Clinical Investigations.
  doi: 10.1172/JCI23409
  contributor:
    fullname: BT Messmer
– volume: 31
  start-page: 639
  year: 1996
  ident: 4404_CR33
  publication-title: J. of Mass Spectrometry.
  doi: 10.1002/(SICI)1096-9888(199606)31:6<639::AID-JMS336>3.0.CO;2-S
  contributor:
    fullname: SF Previs
– volume: 2
  start-page: 3058
  year: 2007
  ident: 4404_CR9
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2007.421
  contributor:
    fullname: JN Voogt
– volume: 7
  start-page: 231
  year: 2007
  ident: 4404_CR12
  publication-title: Nature Reviews Immunology.
  doi: 10.1038/nri2037
  contributor:
    fullname: AN Akbar
– volume: 172
  start-page: 363
  year: 2013
  ident: 4404_CR36
  publication-title: Clinical and Experimental Immunology.
  doi: 10.1111/cei.12064
  contributor:
    fullname: JB Bollyky
– volume: 99
  start-page: 15345
  year: 2002
  ident: 4404_CR6
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.232551499
  contributor:
    fullname: RA Neese
– volume: 41
  start-page: 363
  year: 1985
  ident: 4404_CR30
  publication-title: The American Journal of Clinical Nutrition.
  doi: 10.1093/ajcn/41.2.363
  contributor:
    fullname: HC Lukaski
– volume: 94
  start-page: 2203
  year: 2003
  ident: 4404_CR38
  publication-title: Journal of Applied Physiology.
  doi: 10.1152/japplphysiol.00691.2002
  contributor:
    fullname: ML Collins
– volume: 95
  start-page: 708
  year: 1998
  ident: 4404_CR5
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.95.2.708
  contributor:
    fullname: DC Macallan
– volume: 8
  start-page: 2140
  year: 2009
  ident: 4404_CR19
  publication-title: Journal of Proteome Research.
  doi: 10.1021/pr8009879
  contributor:
    fullname: C Fenselau
– volume: 2
  start-page: 147
  year: 2003
  ident: 4404_CR21
  publication-title: Journal of Proteome Research.
  doi: 10.1021/pr025572s
  contributor:
    fullname: X Yao
– volume: 2
  start-page: 3045
  year: 2007
  ident: 4404_CR2
  publication-title: Nature Protocols.
  doi: 10.1038/nprot.2007.420
  contributor:
    fullname: R Busch
– volume: 50
  start-page: 838
  year: 2015
  ident: 4404_CR39
  publication-title: J. Mass Spectrometry.
  doi: 10.1002/jms.3593
  contributor:
    fullname: DK Walker
– volume: 33
  start-page: 2686
  year: 1980
  ident: 4404_CR27
  publication-title: American Journal of Clinical Nutrition.
  doi: 10.1093/ajcn/33.12.2686
  contributor:
    fullname: DA Schoeller
– volume: 98
  start-page: 463
  year: 1991
  ident: 4404_CR40
  publication-title: J. of Cell Science
  doi: 10.1242/jcs.98.4.463
  contributor:
    fullname: J Lamprecht
– volume: 75
  start-page: 6517
  year: 2003
  ident: 4404_CR3
  publication-title: Analytical Chemistry.
  doi: 10.1021/ac030186v
  contributor:
    fullname: SD Fox
– volume: 298
  start-page: 189
  year: 2001
  ident: 4404_CR7
  publication-title: Analytical Biochemistry.
  doi: 10.1006/abio.2001.5375
  contributor:
    fullname: RA Neese
– volume: 85
  start-page: 4613
  year: 2013
  ident: 4404_CR10
  publication-title: Analytical Chemistry.
  doi: 10.1021/ac400309d
  contributor:
    fullname: DE Farthing
– volume: 84
  start-page: E94
  year: 2006
  ident: 4404_CR20
  publication-title: J. Anim. Sci.
  doi: 10.2527/2006.8413_supplE94x
  contributor:
    fullname: EJ Murphy
– volume: 102
  start-page: 2068
  year: 2003
  ident: 4404_CR8
  publication-title: Blood.
  doi: 10.1182/blood-2003-01-0139
  contributor:
    fullname: GN Schwartz
SSID ssj0000529419
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Snippet Deuterated water ( 2 H 2 O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently,...
Deuterated water ( H O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it...
Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it...
Abstract Deuterated water (2H2O) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More...
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631/1647/2196/1379
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631/92/147
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Animals
Body water
Bone marrow
Cell growth
Cell Line, Tumor
Cell Proliferation
Deoxyadenosine
Deoxyribonucleic acid
Deuterium
Deuterium Oxide - pharmacology
DNA
DNA - chemistry
DNA - genetics
DNA Replication - drug effects
Headspace
Heavy water
Humanities and Social Sciences
Ionization
Isotope Labeling
Isotopes
Kinases
Mass Spectrometry
Mice
multidisciplinary
Quantitation
Radioactive labeling
Science
Science (multidisciplinary)
Stable isotopes
Thymus
Water levels
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Title Comparing DNA enrichment of proliferating cells following administration of different stable isotopes of heavy water
URI https://link.springer.com/article/10.1038/s41598-017-04404-2
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