Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

• Published in: Journal of translational medicine Vol. 20; no. 1; pp. 1 - 290
• Main Authors: Cocco, Stefania, Leone, Alessandra, Roca, Maria Serena, Lombardi, Rita, Piezzo, Michela, Caputo, Roberta, Ciardiello, Chiara, Costantini, Susan, Bruzzese, Francesca, Sisalli, Maria José, Budillon, Alfredo, De Laurentiis, Michelino
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 27.06.2022; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Annexin V; Antitumor activity; Apoptosis; Autophagy; Autophagy (Cytology); Breast Cancer; Cancer therapies; Care and treatment; Cell cycle; Cell growth; Chemotherapy; Chloroquine; Clinical trials; Diagnosis; Dosage and administration; Drug resistance; Drugs; Flow cytometry; Health aspects; Immunoblotting; Immunofluorescence; Metastasis; Mutation; Paclitaxel; Physiological aspects; Physiology; PI3K/AKT/mTOR inhibitors; Poly(ADP-ribose) polymerase; Proteins; Spheroids; TNBC; Tumor cell lines; Tumors; Xenografts; Italy; United States > US

Abstract Background Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investigated in TNBC with modest results in clinical trials. Among these, PI3K/...