Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

• Published in: Nature communications Vol. 12; no. 1; pp. 2681 - 17
• Main Authors: Xing, Junji, Zhang, Ao, Du, Yong, Fang, Mingli, Minze, Laurie J., Liu, Yong-Jun, Li, Xian Chang, Zhang, Zhiqiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/1; 13/21; 13/31; 13/95; 14/19; 38/109; 38/91; 631/250; 631/250/262/2106; 64/60; 692/420/254; 692/699/255/2514; 82/80; 96/109; Adenosine diphosphate; Animals; Antiviral drugs; Chlorocebus aethiops; Dendritic cells; Dendritic Cells - enzymology; Dendritic Cells - virology; Humanities and Social Sciences; Humans; Immune system; Infections; Interferon; Interferon regulatory factor 3; Interferon regulatory factor 7; Interferon Regulatory Factor-3 - metabolism; Interferon Regulatory Factor-7 - metabolism; Interferon Type I - metabolism; Kinases; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria; multidisciplinary; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Nucleic acids; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Poly(ADP-ribose); Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerases - genetics; Poly(ADP-ribose) Polymerases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Ribonucleic acid; Ribose; RNA; RNA Virus Infections - enzymology; RNA Virus Infections - virology; RNA viruses; RNA Viruses - genetics; RNA Viruses - physiology; RNA, Viral - metabolism; Science; Science (multidisciplinary); Sensors; Signal Transduction; THP-1 Cells; Vero Cells; Viral infections; Viruses

Innate immune cells are critical in protective immunity against viral infections, involved in sensing foreign viral nucleic acids. Here we report that the poly(ADP-ribose) polymerase 9 (PARP9), a member of PARP family, serves as a non-canonical sensor for RNA virus to initiate and amplify type I int...