Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos

• Published in: Nature communications Vol. 13; no. 1; p. 346
• Main Authors: Li, Chen C., Zhang, Guangyu, Du, Junjie, Liu, Di, Li, Zongcheng, Ni, Yanli, Zhou, Jie, Li, Yunqiao, Hou, Siyuan, Zheng, Xiaona, Lan, Yu, Liu, Bing, He, Aibin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 45/15; 45/23; 631/136/232; 631/136/532; 631/208/177; 64; 64/60; Animals; Cell differentiation; Cell lineage; Chromatin; Chromatin - chemistry; Cluster Analysis; Core Binding Factor Alpha 2 Subunit - metabolism; Differentiation (biology); Embryo, Mammalian - cytology; Embryos; Endothelial cells; Enhancer Elements, Genetic - genetics; Enhancers; Genome; Genomes; Hematopoiesis; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Histone Code; Histones; Humanities and Social Sciences; Mice; Mice, Inbred C57BL; Molecular Sequence Annotation; multidisciplinary; Multilayers; Ontogeny; Promoter Regions, Genetic - genetics; Regulatory sequences; Runx1 protein; Science; Science (multidisciplinary); Stem cell transplantation; Stem cells; Transcription factors; Transcription Factors - metabolism

The gene activity underlying cell differentiation is regulated by a diverse set of transcription factors (TFs), histone modifications, chromatin structures and more. Although definitive hematopoietic stem cells (HSCs) are known to emerge via endothelial-to-hematopoietic transition (EHT), how the mul...