E3 ubiquitin ligase Nedd4 inhibits AP-1 activity and TNF-α production through targeting p38α for polyubiquitination and subsequent degradation - Liu, Qingjun; Zhang, Shihui; Chen, Gan; Zhou, Hong (Scientific reports, 2017)
Keywords: 13/109; 13/21; 13/44; 13/89; 13/95; 38/23; 631/250/2504/342/1726; 631/337/458/582; 82/1; 82/58; 82/80; 96/10; Animals; Arthritis; Cell Line, Tumor; Conformation; Dermatitis; Endotoxemia; Enzymes; Gene Knockdown Techniques; Humanities and Social Sciences; Humans; Inflammation; Inflammatory diseases; Isoforms; Kinases; Lipopolysaccharides; Lipopolysaccharides - immunology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Mitogen-Activated Protein Kinase 14 - chemistry; Mitogen-Activated Protein Kinase 14 - metabolism; Models, Molecular; multidisciplinary; Nedd4 Ubiquitin Protein Ligases - chemistry; Nedd4 Ubiquitin Protein Ligases - genetics; Nedd4 Ubiquitin Protein Ligases - metabolism; Phosphorylation; Protein Conformation; Protein Domains; Proteins; Proteolysis; Science; Science (multidisciplinary); Shock; Skin; Skin diseases; TAK1 protein; Transcription Factor AP-1 - metabolism; Transcription factors; Tumor Necrosis Factor-alpha - biosynthesis; Tumor necrosis factor-α; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination