Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect

• Published in: Nature communications Vol. 11; no. 1; pp. 183 - 15
• Main Authors: Pi, Guilin, Gao, Di, Wu, Dongqin, Wang, Yali, Lei, Huiyang, Zeng, Wenbo, Gao, Yang, Yu, Huiling, Xiong, Rui, Jiang, Tao, Li, Shihong, Wang, Xin, Guo, Jing, Zhang, Si, Yin, Taoyuan, He, Ting, Ke, Dan, Li, Ruining, Li, Honglian, Liu, Gongping, Yang, Xifei, Luo, Min–Hua, Zhang, Xiaohui, Yang, Ying, Wang, Jian–Zhi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/109; 14/19; 38/35; 631/378/3920; 64/60; 692/699/375/365/1283; 692/699/476/1300; 82/47; 82/80; 9/74; Alzheimer Disease - metabolism; Alzheimer's disease; Amygdala; Animal behavior; Animals; Anti-Anxiety Agents - pharmacology; Anxiety; Approach behavior; Basolateral Nuclear Complex - metabolism; Behavior, Animal; CA1 Region, Hippocampal - metabolism; Calbindin; Calbindin 1 - genetics; Calbindin 1 - metabolism; Choice Behavior - physiology; Circuits; Decision Making; Hippocampus; Humanities and Social Sciences; Male; Maze Learning - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Neurodegenerative diseases; Neurons; Neurons - physiology; Posterior basolateral amygdala; Presenilin 1; Proteomics; Science; Science (multidisciplinary)

The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly and functionally diverse along their anterior–posterior and superficial-deep axes. Here, we find that anterior BLA (aBLA) and posterior BLA (pBLA) innervate deep-layer calbindin1-negative (Calb1−) and superficial-layer...