IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα

• Published in: Experimental and therapeutic medicine Vol. 11; no. 2; pp. 631 - 636
• Main Authors: MA, WEI-YUAN, JIA, KUN, ZHANG, YAN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Analysis; Binding proteins; Biopsy; Biotechnology; Care and treatment; CCATT/enhancer binding protein α; Cell cycle; Cell growth; Cell proliferation; Genetic aspects; interleukin-17; Interleukins; keratinocyte; Keratinocytes; Kinases; Pathogenesis; proliferation; Protein expression; Proteins; Psoriasis; psoriasis vulgaris; Transcription factors; Tumors; China; CCATT/enhancer binding protein α; interleukin-17; proliferation; psoriasis vulgaris; keratinocyte

Psoriasis vulgaris is a common chronic inflammatory skin disease characterized by the hyperproliferation and abnormal differentiation of keratinocytes. CCATT/enhancer binding protein α (C/EBPα) is abundant in the epidermis and is associated with the proliferation of keratinocytes. However, the role...