Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target

• Published in: The Journal of biological chemistry Vol. 285; no. 30; pp. 22725 - 22731
• Main Authors: Raney, Kevin D., Sharma, Suresh D., Moustafa, Ibrahim M., Cameron, Craig E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.07.2010; American Society for Biochemistry and Molecular Biology
• Subjects: Antiviral Agents; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; Enzyme Mechanisms; Hepacivirus - metabolism; Hepatitis C virus; Hepatitis C Virus (HCV); Hepatitis Virus; Immunity, Innate - immunology; Microbiology; Minireviews; Non-structural Protein 3 (NS3); Nucleic Acids - chemistry; Nucleic Acids - metabolism; Protease; Protein Multimerization; RNA Helicase; Viral Nonstructural Proteins - antagonists & inhibitors; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - immunology; Viral Nonstructural Proteins - metabolism; Enzyme Mechanisms; Non-structural Protein 3 (NS3); RNA Helicase; Hepatitis Virus; Protease; Hepatitis C Virus (HCV); Antiviral Agents

Hepatitis C virus non-structural protein 3 contains a serine protease and an RNA helicase. Protease cleaves the genome-encoded polyprotein and inactivates cellular proteins required for innate immunity. Protease has emerged as an important target for the development of antiviral therapeutics, but dr...