Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects

• Published in: Nature communications Vol. 13; no. 1; p. 7838
• Main Authors: Chen, Kang, Cheong, Lai Yee, Gao, Yuan, Zhang, Yaming, Feng, Tianshi, Wang, Qin, Jin, Leigang, Honoré, Eric, Lam, Karen S. L., Wang, Weiping, Hui, Xiaoyan, Xu, Aimin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/31; 14/19; 38/77; 64/60; 692/163/2743; 692/698/690/2816; 692/700/565/1436; 82/51; Adipose tissue; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - metabolism; Animals; Apolipoprotein E; Arteriosclerosis; Atherosclerosis; Atherosclerosis - metabolism; Body fat; Body weight loss; Complications; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Fatty liver; Feedback; Glucose tolerance; Humanities and Social Sciences; Hypercholesterolemia; Innervation; Insulin; Insulin resistance; Intolerance; Liposomes; Mice; Mice, Inbred C57BL; multidisciplinary; Obesity; Obesity - metabolism; Science; Science (multidisciplinary); Side effects; Therapy; Thermogenesis; Thyroid; Thyroid gland; Thyroid hormones; Thyroid Hormones - metabolism; Triiodothyronine; Triiodothyronine - metabolism; Weight control; Weight loss; Weight reduction

Thyroid hormone (TH) is a thermogenic activator with anti-obesity potential. However, systemic TH administration has no obvious clinical benefits on weight reduction. Herein we selectively delivered triiodothyronine (T3) to adipose tissues by encapsulating T3 in liposomes modified with an adipose ho...