A population-specific HTR2B stop codon predisposes to severe impulsivity

• Published in: Nature (London) Vol. 468; no. 7327; pp. 1061 - 1066
• Main Authors: Bevilacqua, Laura, Doly, Stéphane, Kaprio, Jaakko, Yuan, Qiaoping, Tikkanen, Roope, Paunio, Tiina, Zhou, Zhifeng, Wedenoja, Juho, Maroteaux, Luc, Diaz, Silvina, Belmer, Arnaud, Hodgkinson, Colin A., Dell’Osso, Liliana, Suvisaari, Jaana, Coccaro, Emil, Rose, Richard J., Peltonen, Leena, Virkkunen, Matti, Goldman, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.12.2010; Nature Publishing Group
• Subjects: 631/208/727/2000; 692/1807; 692/699/476; Aggressive behavior; Animals; Behavior; Biochemistry, Molecular Biology; Biological and medical sciences; Brain - metabolism; Case-Control Studies; Cell Line; Female; Finland; Founder Effect; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Gene Knockout Techniques; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Genotype & phenotype; Human; Humanities and Social Sciences; Humans; Impulsive Behavior - genetics; Life Sciences; Male; Mental Disorders - genetics; Mice; Mice, 129 Strain; Mice, Knockout; multidisciplinary; Neurological disorders; Neurology; Neurotransmitters; Pedigree; Polymorphism, Single Nucleotide - genetics; Population genetics, reproduction patterns; Receptor, Serotonin, 5-HT2B - genetics; Receptor, Serotonin, 5-HT2B - metabolism; Science; Science (multidisciplinary); Testosterone - blood; Testosterone - cerebrospinal fluid; Violence; Finland; Human; Impulsivity; Founder effect; Severe; Nonsense mutation; Population genetics

Impulsivity, describing action without foresight, is an important feature of several psychiatric diseases, suicidality and violent behaviour. The complex origins of impulsivity hinder identification of the genes influencing it and the diseases with which it is associated. Here we perform exon-focuse...