Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy

• Published in: Nature reviews. Clinical oncology Vol. 12; no. 6; pp. 335 - 343
• Main Authors: King, Tari A., Morrow, Monica
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2015; Nature Publishing Group
• Subjects: 692/308/409; 692/699/67/1059/99; 692/699/67/1347; 692/700/565/545/546; Adjuvant treatment; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - surgery; Cancer; Care and treatment; Chemotherapy, Adjuvant - methods; Clinical Trials as Topic; Excision (Surgery); False Negative Reactions; Female; Humans; Lymphatic Metastasis; Mastectomy, Segmental - methods; Medicine & Public Health; Neoadjuvant Therapy - methods; Neoplasm, Residual - drug therapy; Neoplasm, Residual - surgery; Oncology; Patient Selection; Preoperative Care; Randomized Controlled Trials as Topic; review-article; Sentinel Lymph Node Biopsy

Key Points Neoadjuvant chemotherapy (NACT) does not prolong survival compared with adjuvant chemotherapy, but reduces the need for mastectomy and axillary lymph-node dissection, and thus surgical morbidity, without increasing the risk of locoregional recurrence Patients with high-grade oestrogen rec...