Inflammatory Pattern of the Bronchial Mucosa in Patients with Asthma with Airway Hyperresponsiveness to Hypoosmotic Stimulus

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 4; pp. 550 - 553
• Main Authors: Pirogov, A. B., Prikhod’ko, A. G., Perelman, Yu. M., Zinovyev, S. V., Afanasyeva, E. Yu, Kolosov, V. P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2016; Springer; Springer Nature B.V
• Subjects: Adult; Analysis; Asthma; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; Biomedical and Life Sciences; Biomedicine; Bronchi - immunology; Bronchi - physiopathology; Bronchial Hyperreactivity - immunology; Bronchial Hyperreactivity - metabolism; Bronchial Hyperreactivity - physiopathology; Care and treatment; Cell Biology; Eosinophils - immunology; Experimental Methods for Clinical Practice; Female; Humans; Inflammation - immunology; Inflammation - metabolism; Internal Medicine; Laboratory Medicine; Macrophages - immunology; Male; Neutrophils - immunology; Oxidases; Pathology; Peroxidase - metabolism; Young Adult; myeloperoxidase; cytolysis; eosinophilic and neutrophilic leukocytes; osmotic airway hyperresponsiveness; inflammation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3458-3

Positive reaction of the bronchi to distilled water inhalation in asthmatics is associated with significant stimulation of the respiratory epithelium desquamation against the background of increased content of eosinophilic and neutrophilic leukocytes in induced sputum, predomination of eosinophil and neutrophil cytolysis, and lower activity of myeloperoxidase in leukocyte granules (in comparison with the parameter in patients with a negative response to bronchostimulation). Enhanced cytolysis and destruction of leukocytes and high myeloperoxidase concentration in the extracellular space are essential for the development of bronchial hyperresponsiveness to hypoosmotic stimulus in asthma.