Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

• Published in: Nature medicine Vol. 28; no. 5; pp. 1050 - 1062
• Main Authors: Sacco, Keith, Castagnoli, Riccardo, Vakkilainen, Svetlana, Liu, Can, Delmonte, Ottavia M., Oguz, Cihan, Kaplan, Ian M., Alehashemi, Sara, Burbelo, Peter D., Bhuyan, Farzana, de Jesus, Adriana A., Dobbs, Kerry, Rosen, Lindsey B., Cheng, Aristine, Shaw, Elana, Vakkilainen, Mikko S., Pala, Francesca, Lack, Justin, Zhang, Yu, Fink, Danielle L., Oikonomou, Vasileios, Snow, Andrew L., Dalgard, Clifton L., Chen, Jinguo, Sellers, Brian A., Montealegre Sanchez, Gina A., Barron, Karyl, Rey-Jurado, Emma, Vial, Cecilia, Poli, Maria Cecilia, Licari, Amelia, Montagna, Daniela, Marseglia, Gian Luigi, Licciardi, Francesco, Ramenghi, Ugo, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Eisenstein, Eli M., Imberti, Luisa, Sottini, Alessandra, Biondi, Andrea, Mató, Sayonara, Gerstbacher, Dana, Truong, Meng, Stack, Michael A., Magliocco, Mary, Bosticardo, Marita, Kawai, Tomoki, Danielson, Jeffrey J., Hulett, Tyler, Askenazi, Manor, Hu, Shaohui, Cohen, Jeffrey I., Su, Helen C., Kuhns, Douglas B., Lionakis, Michail S., Snyder, Thomas M., Holland, Steven M., Goldbach-Mansky, Raphaela, Tsang, John S., Notarangelo, Luigi D.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2022; Nature Publishing Group
• Subjects: 631/208/514/1949; 631/250/256; 631/326/596/4130; 692/420/2780; 692/699/255/2514; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell activation; Child; Children; Coronaviruses; COVID-19; COVID-19 - complications; COVID-19 - genetics; Gene expression; Histocompatibility antigen HLA; Humans; Infectious Diseases; Inflammation; Interferon; Lymphocytes; Lymphocytes B; Lymphocytes T; Metabolic Diseases; Molecular Medicine; Morbidity; Multisystem inflammatory syndrome in children; Mutation; Mutation rates; Neurosciences; NF-κB protein; Pediatrics; Proteins; Proteomics; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike protein; Systemic Inflammatory Response Syndrome - genetics; T-Lymphocytes; Transcriptomics; Viral diseases

Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might develop multisystem inflammatory syndrome in children (MIS-C), with substantial morbidity. In this longitudinal multi-inst...