Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

• Published in: Nature communications Vol. 9; no. 1; pp. 4412 - 11
• Main Authors: Readhead, Benjamin, Hartley, Brigham J., Eastwood, Brian J., Collier, David A., Evans, David, Farias, Richard, He, Ching, Hoffman, Gabriel, Sklar, Pamela, Dudley, Joel T., Schadt, Eric E., Savić, Radoslav, Brennand, Kristen J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.10.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/100; 38/39; 49; 631/114/2401; 631/154/1435/2163; 631/532/2064/2158; Cancer; Cell Line; Cell Line, Tumor; Cells (biology); Dimethyl Sulfoxide - pharmacology; Drug screening; Gene expression; Humanities and Social Sciences; Humans; Induced Pluripotent Stem Cells - drug effects; Induced Pluripotent Stem Cells - metabolism; Mental disorders; multidisciplinary; Neural stem cells; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Pluripotency; Progenitor cells; Quality Control; Schizophrenia; Schizophrenia - metabolism; Science; Science (multidisciplinary); Screening; Signatures; Stem cells; Transcription; Transcriptome; Tumor cell lines

A lack of biologically relevant screening models hinders the discovery of better treatments for schizophrenia (SZ) and other neuropsychiatric disorders. Here we compare the transcriptional responses of 8 commonly used cancer cell lines (CCLs) directly with that of human induced pluripotent stem cell...