Expansion of restricted cellular immune responses to HIV‐1 envelope by vaccination: IL‐7 and IL‐12 differentially augment cellular proliferative responses to HIV‐1

• Published in: Clinical and experimental immunology Vol. 108; no. 2; pp. 243 - 250
• Main Authors: KIM, J. H., LOVELAND, J. E., SITZ, K. V., RATTO KIM, S., MCLINDEN, R. J., TENCER, K., DAVIS, K., BURKE, D. S., BOSWELL, R. N., REDFIELD, R. R., BIRX, D. L.
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.05.1997; Blackwell; Blackwell Science Inc
• Subjects: Adjuvants, Immunologic - pharmacology; AIDS Vaccines - immunology; AIDS/HIV; Biological and medical sciences; Cohort Studies; Female; HIV Core Protein p24 - biosynthesis; HIV Core Protein p24 - immunology; HIV Envelope Protein gp160 - immunology; HIV Infections - immunology; HIV-1 - immunology; HIV‐1; human immunodeficiency virus 1; Humans; IL‐12; IL‐7; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Interleukin-12 - pharmacology; Interleukin-7 - pharmacology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Lymphocyte Activation - drug effects; Male; Medical sciences; Original; T cell; Tetanus Toxoid - immunology; Vaccines, Synthetic - immunology; Human; Immunopathology; Immune response; HIV-1 virus; Retroviridae; Interleukin 12; AIDS; Cellular immunity; Vaccine; Immune deficiency; Active immunization; Infection; Virus; Interleukin 7; Treatment; Viral disease; Immunotherapy; T-Lymphocyte; Lentivirinae; Human immunodeficiency virus; Virus envelope

The failure of immune effector mechanisms to control HIV‐1 infection has important consequences for the human host. In a randomized cohort of HIV‐infected patients, there was striking in vitro restriction of the proliferative response to HIV‐1 envelope protein (Env), gp160; only 34% of patients reco...