The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine
In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery in which intrathecal morphine was administered. Each patient received intrathecal morphine 0.3 mg prior to induction, followed by a standard anaesthetic. The patients were randomly allocat...
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Published in | Anaesthesia Vol. 54; no. 10; pp. 948 - 952 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Blackwell Science Ltd
01.10.1999
Blackwell |
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Abstract | In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery in which intrathecal morphine was administered. Each patient received intrathecal morphine 0.3 mg prior to induction, followed by a standard anaesthetic. The patients were randomly allocated to one of two groups. One group received 100 mg of rectal diclofenac immediately post‐induction. Patients receiving diclofenac had significantly lower pruritus scores at 30 min (p = 0.0076), 2, 4, 8 and 24 h postoperatively, as well as significantly reduced pain scores at each time point (p < 0.0001 at each study interval). Morphine consumption in the first 24 h was also significantly lower in this group. In conclusion, rectal administration of diclofenac significantly reduces the incidence and severity of postoperative pruritus. It also significantly reduces pain and further analgesic requirements postoperatively. |
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AbstractList | In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery in which intrathecal morphine was administered. Each patient received intrathecal morphine 0.3 mg prior to induction, followed by a standard anaesthetic. The patients were randomly allocated to one of two groups. One group received 100 mg of rectal diclofenac immediately post‐induction. Patients receiving diclofenac had significantly lower pruritus scores at 30 min (p = 0.0076), 2, 4, 8 and 24 h postoperatively, as well as significantly reduced pain scores at each time point (p < 0.0001 at each study interval). Morphine consumption in the first 24 h was also significantly lower in this group. In conclusion, rectal administration of diclofenac significantly reduces the incidence and severity of postoperative pruritus. It also significantly reduces pain and further analgesic requirements postoperatively. |
Author | Chambers, F. Galvin, S. Moriarty, D. C. Colbert, S. O'hanlon, D. M. |
Author_xml | – sequence: 1 givenname: S. surname: Colbert fullname: Colbert, S. – sequence: 2 givenname: D. M. surname: O'hanlon fullname: O'hanlon, D. M. – sequence: 3 givenname: S. surname: Galvin fullname: Galvin, S. – sequence: 4 givenname: F. surname: Chambers fullname: Chambers, F. – sequence: 5 givenname: D. C. surname: Moriarty fullname: Moriarty, D. C. |
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Keywords | Human Postoperative Skin disease Toxicity Morphine Opiates Pruritus Narcotic analgesic Intrathecal administration Rectal administration Diclofenac Non steroidal antiinflammatory agent Prevention Analgesia Chemotherapy Arylacetic acid derivatives Pain Complication Skin |
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SubjectTerms | Abdomen - surgery Administration, Rectal Aged Analgesics, Opioid - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biological and medical sciences Complications; pruritus Diclofenac - therapeutic use Drug Administration Schedule Drug toxicity and drugs side effects treatment Female Humans Male Medical sciences Middle Aged Morphine - adverse effects Nonsteroidal anti‐inflammatory drugs; diclofenac Opioids, spinal; morphine Pain, Postoperative - prevention & control Pharmacology. Drug treatments Prospective Studies Pruritus - chemically induced Pruritus - prevention & control Toxicity: skin, dermoskeleton |
Title | The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine |
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