Influence of Body Mass Index on Outcome of Pediatric Chronic Hepatitis C Virus Infection

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 51; no. 2; pp. 191 - 197
• Main Authors: Delgado‐Borrego, Aymin, Healey, David, Negre, Betania, Christofi, Marielle, Sabharwal, Sabina, Ludwig, David A, Chung, Raymond T, Jonas, Maureen M
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Copyright by ESPGHAN and NASPGHAN 01.08.2010; Lippincott Williams & Wilkins
• Subjects: Adolescent; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological and medical sciences; Body Mass Index; Child; Disease Progression; Drug Resistance, Viral; Fatty Liver - drug therapy; Fatty Liver - etiology; Fatty Liver - virology; Feeding. Feeding behavior; Female; fibrosis; Fundamental and applied biological sciences. Psychology; Hepacivirus - drug effects; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Human viral diseases; Humans; Infectious diseases; interferon; Male; Medical sciences; Metabolic diseases; Models, Statistical; Multivariate Analysis; Obesity; Obesity - complications; pediatric; Retrospective Studies; steatosis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Viral diseases; Viral hepatitis; Human; Obesity; Pediatrics; Prognosis; Cytokine; Nutrition disorder; Hepatic disease; Metabolic diseases; Steatosis; pediatric; Infection; Body mass index; Viral disease; Fibrosis; Gastroenterology; Digestive diseases; Interferon; Child; Nutritional status; Viral hepatitis C

ABSTRACT Background and Aims: Evidence demonstrates that obesity is associated with progression of chronic hepatitis C virus (HCV) infection and poor response to interferon therapy among HCV‐infected adults. However, this evidence has been confounded by multiple comorbidities present in adult cohort...