Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

• Published in: Cell Vol. 165; no. 4; pp. 1012 - 1026
• Main Authors: Petropoulos, Sophie, Edsgärd, Daniel, Reinius, Björn, Deng, Qiaolin, Panula, Sarita Pauliina, Codeluppi, Simone, Plaza Reyes, Alvaro, Linnarsson, Sten, Sandberg, Rickard, Lanner, Fredrik
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.05.2016; Cell Press
• Subjects: alleles; blastocyst; Blastocyst - metabolism; Blastocyst Inner Cell Mass - metabolism; Chromosomes, Human, X; Dosage Compensation, Genetic; embryogenesis; Female; females; human development; Humans; Male; mice; Resource; RNA; RNA, Long Noncoding - genetics; sequence analysis; Sequence Analysis, RNA; Sex Characteristics; Single-Cell Analysis; stem cells; transcription (genetics); Transcriptome; X chromosome

Mouse studies have been instrumental in forming our current understanding of early cell-lineage decisions; however, similar insights into the early human development are severely limited. Here, we present a comprehensive transcriptional map of human embryo development, including the sequenced transc...