Betaine Inhibits NLRP3 Inflammasome Hyperactivation and Regulates Microglial M1/M2 Phenotypic Differentiation, Thereby Attenuating Lipopolysaccharide-Induced Depression-Like Behavior

• Published in: Journal of Immunology Research Vol. 2022; pp. 1 - 14
• Main Authors: Zhang, Man, Wang, Xiao-Long, Shi, Hui, Meng, Lan-Qing, Quan, Hong-Feng, Yan, Lin, Yang, Hui-Fang, Peng, Xiao-Dong
• Format: Journal Article
• Language: English
• Published: New York Hindawi 26.10.2022; John Wiley & Sons, Inc; Hindawi Limited; Wiley
• Subjects: Animals; Antidepressants; Behavior; Betaine; Brain; Caspase-1; Cytokines; Depression, Mental; Drinking water; Enzyme-linked immunosorbent assay; Food; Genotype & phenotype; Herbal medicine; Hypotheses; IL-1β; Immunofluorescence; Immunohistochemistry; Immunology; Inflammasomes; Inflammation; Lipopolysaccharides; Mental depression; Mental disorders; Microglia; Morphology; Natural products; Nervous system; Neuroprotection; Nitric oxide; Nitric-oxide synthase; Oligomerization; Open-field behavior; Phenotypes; Polarization; Protein binding; Sucrose; Tetracycline; Tetracyclines; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Western blotting; China

Depression is one of the most important mental illnesses and is closely related to inflammation. Betaine is a natural product with an anti-inflammatory and antioxidant activities. However, the mechanism by which betaine ameliorates depression-like behaviors induced by lipopolysaccharide (LPS) is poo...