All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved]

• Published in: F1000 research Vol. 9; p. 69
• Main Author: Fasano, Alessio
• Format: Journal Article
• Language: English
• Published: England Faculty of 1000 Ltd 2020; F1000 Research Limited; F1000 Research Ltd
• Subjects: Antigens; Cholera Toxin; Digestive system; Environmental changes; Enzymes; Epidemics; Gastrointestinal Microbiome; Gastrointestinal tract; Genomes; Genomics; Haptoglobins; Humans; Hypotheses; Immune response; Immunological tolerance; Infectious diseases; Inflammatory diseases; Intestinal microflora; Intestinal Mucosa; Intestine; Kinases; Microbiomes; Microbiota; Microorganisms; Mucosa; Mutation; Pathogenesis; Permeability; Physiology; Protein Precursors; Proteins; Proteomics; Review; Therapeutic applications; Transgenic animals; Tumor necrosis factor-TNF; Gut permeability; zonulin; Chronic inflammatory diseases; microbiome

Improved hygiene leading to reduced exposure to microorganisms has been implicated as one possible cause for the recent "epidemic" of chronic inflammatory diseases (CIDs) in industrialized countries. That is the essence of the hygiene hypothesis that argues that rising incidence of CIDs ma...