C242T CYBA Polymorphism of the NADPH Oxidase Is Associated With Reduced Respiratory Burst in Human Neutrophils

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 43; no. 6; pp. 1246 - 1251
• Main Authors: Wyche, Keith E., Wang, Shaoshan S., Griendling, Kathy K., Dikalov, Sergey I., Austin, Harland, Rao, Swapna, Fink, Bruno, Harrison, David G., Zafari, A. Maziar
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.06.2004; Hagerstown, MD Lippincott
• Subjects: Adult; Alleles; Amino Acid Substitution; Arterial hypertension. Arterial hypotension; Arteriosclerosis - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Codon - genetics; Experimental diseases; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Medical sciences; Membrane Transport Proteins - genetics; Middle Aged; NADPH Dehydrogenase - genetics; NADPH Oxidases - metabolism; Neutrophils - drug effects; Neutrophils - metabolism; Oxidative Stress - genetics; Phosphoproteins - genetics; Polymorphism, Single Nucleotide; Respiratory Burst - drug effects; Respiratory Burst - genetics; Superoxides - metabolism; Tetradecanoylphorbol Acetate - pharmacology; Human; Hypertension; NADPH; Oxidative stress; risk factors; Enzyme; Oxidase; Cardiovascular disease; Vascular disease; Atherosclerosis; Risk factor; Oxidoreductases; Neutrophil; neutrophils; Polymorphism

Oxidative stress contributes to the pathogenesis of atherosclerosis. p22-based NAD(P)H oxidases exist in the vessel wall, acting as important superoxide-generating systems in the vasculature. Some studies have identified reduced atherosclerosis in the presence of the C242T CYBA polymorphism, whereas...