Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study

• Published in: European journal of neurology Vol. 16; no. 7; pp. 808 - 813
• Main Authors: Kivipelto, M., Annerbo, S., Hultdin, J., Bäckman, L., Viitanen, M., Fratiglioni, L., Lökk, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2009
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - epidemiology; Alzheimer Disease - metabolism; Alzheimers disease; Community Health Planning; dementia; Dementia - epidemiology; Dementia - metabolism; Female; holo-transcobalamin; homocysteine; Homocysteine - metabolism; Humans; Male; Medicin och hälsovetenskap; Models, Anatomic; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Transcobalamins - metabolism

Background:  Elevated total homocysteine (tHcy) levels may be caused by vitamin B12 deficiency and are linked to Alzheimers disease (AD) in some studies, although the evidence is mixed. Another marker of vitamin B12 deficiency, holo‐transcobalamin (holo‐TC), has not been studied in a prospective set...