Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue

• Published in: Circulation Vol. 142; no. 14; pp. 1374 - 1388
• Main Authors: Li, Yanming, Ren, Pingping, Dawson, Ashley, Vasquez, Hernan G., Ageedi, Waleed, Zhang, Chen, Luo, Wei, Chen, Rui, Li, Yumei, Kim, Sangbae, Lu, Hong S., Cassis, Lisa A., Coselli, Joseph S., Daugherty, Alan, Shen, Ying H., LeMaire, Scott A.
• Format: Journal Article
• Language: English
• Published: Ovid Technologies (Wolters Kluwer Health) 06.10.2020; by the American College of Cardiology Foundation and the American Heart Association, Inc
• Subjects: Aged; Aorta; Aortic Aneurysm, Thoracic; Female; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Humans; Male; Middle Aged; Single-Cell Analysis

Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and other life-threatening complications. To improve our understanding of ATAA pathogenesis, we aimed to comprehensively characterize the cel...