HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

• Published in: Journal of neurovirology Vol. 17; no. 1; pp. 3 - 16
• Main Authors: Heaton, Robert K., Franklin, Donald R., Ellis, Ronald J., McCutchan, J. Allen, Letendre, Scott L., LeBlanc, Shannon, Corkran, Stephanie H., Duarte, Nichole A., Clifford, David B., Woods, Steven P., Collier, Ann C., Marra, Christina M., Morgello, Susan, Mindt, Monica Rivera, Taylor, Michael J., Marcotte, Thomas D., Atkinson, J. Hampton, Wolfson, Tanya, Gelman, Benjamin B., McArthur, Justin C., Simpson, David M., Abramson, Ian, Gamst, Anthony, Fennema-Notestine, Christine, Jernigan, Terry L., Wong, Joseph, Grant, Igor
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2011
• Subjects: Adult; AIDS Dementia Complex - complications; AIDS Dementia Complex - drug therapy; AIDS Dementia Complex - epidemiology; Antiretroviral Therapy, Highly Active; Biomedical and Life Sciences; Biomedicine; Female; HIV - pathogenicity; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; Human immunodeficiency virus; Humans; Immunology; Infectious Diseases; Longitudinal Studies; Male; Middle Aged; Neurology; Neurosciences; Prevalence; Treatment Outcome; Virology; Young Adult; HIV; Combination antiretroviral therapy; HIV dementia

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV−) groups have not been studied with simila...