5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers

• Published in: Cell research Vol. 27; no. 10; pp. 1243 - 1257
• Main Authors: Li, Wenshuai, Zhang, Xu, Lu, Xingyu, You, Lei, Song, Yanqun, Luo, Zhongguang, Zhang, Jun, Nie, Ji, Zheng, Wanwei, Xu, Diannan, Wang, Yaping, Dong, Yuanqiang, Yu, Shulin, Hong, Jun, Shi, Jianping, Hao, Hankun, Luo, Fen, Hua, Luchun, Wang, Peng, Qian, Xiaoping, Yuan, Fang, Wei, Lianhuan, Cui, Ming, Zhang, Taiping, Liao, Quan, Dai, Menghua, Liu, Ziwen, Chen, Ge, Meckel, Katherine, Adhikari, Sarbani, Jia, Guifang, Bissonnette, Marc B, Zhang, Xinxiang, Zhao, Yupei, Zhang, Wei, He, Chuan, Liu, Jie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2017; Nature Publishing Group
• Subjects: 5-Methylcytosine - analogs & derivatives; 5-Methylcytosine - blood; 5-甲基胞嘧啶; 631/67/1857; 692/53/2421; 692/699/1503/1504; 692/700/1750; Adolescent; Adult; Aged; Biomarkers; Biomarkers, Tumor - blood; Cancer; Cell Biology; Cell-Free Nucleic Acids - blood; Cell-Free Nucleic Acids - genetics; Chromatin; Circulating Tumor DNA - blood; Colorectal cancer; Deoxyribonucleic acid; Diagnosis; Diagnostic systems; DNA; DNA Methylation - genetics; DNA修饰; Epigenetics; Epigenomics; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genomes; Humans; Life Sciences; Liquid Biopsy; Liver; Liver cancer; Male; Middle Aged; Neoplasms - blood; Neoplasms - classification; Neoplasms - genetics; Neoplasms - pathology; Original; original-article; Pancreas; Pancreatic cancer; Thyroid; Thyroid cancer; Transcription; Young Adult; 人类基因组; 生物标志物; 癌症; 签名; 羟甲基; 诊断; 5hmC-Seal; cancer biomarker; liquid biopsy; 5-hydroxymethylcytosine; circulating cell-free DNA

DNA modifications such as 5-methylcytosine （5mC） and 5-hydroxymethylcytosine （5hmC） are epigenetic marks known to affect global gene efpression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high chemical stability, these DNA epigenetic marks could...