Pharmacokinetics and Tolerability of Etamicastat Following Single and Repeated Administration in Elderly Versus Young Healthy Male Subjects: An Open-Label, Single-Center, Parallel-Group Study - Nunes, Teresa; Rocha, José Francisco; Vaz-da-Silva, Manuel; Falcão, Amilcar; Almeida, Luis; Soares-da-Silva, Patricio (Clinical therapeutics, 2011)
Keywords: Adolescent; Adult; age effect; Age Factors; Aged; Area Under Curve; Arterial hypertension. Arterial hypotension; Arylamine N-Acetyltransferase - genetics; Benzopyrans - administration & dosage; Benzopyrans - adverse effects; Benzopyrans - pharmacokinetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Clinical trials; Dopamine; Dopamine beta-Hydroxylase - antagonists & inhibitors; dopamine-β-hydroxylase; dopamine-β-hydroxylase inhibition; Drug Administration Schedule; Drug dosages; Drug therapy; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - pharmacokinetics; etamicastat; Genotype; Heart; heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Hypertension; Imidazoles - administration & dosage; Imidazoles - adverse effects; Imidazoles - pharmacokinetics; Infections; Internal Medicine; Isoenzymes - genetics; Male; Medical Education; Medical sciences; Metabolites; Older people; pharmacokinetics; Pharmacology. Drug treatments; Rodents; Time Factors; Young Adult; heart failure; dopamine-β-hydroxylase; age effect; dopamine-β-hydroxylase inhibition; pharmacokinetics; etamicastat; hypertension; Human; Hypertension; Heart failure; Imidazole derivatives; Dopamine β-monooxygenase; Healthy subject; Etamicastat; Enzyme; Toxicity; Single dose; Cardiovascular disease; Multiple dose; Heart disease; Oxidoreductases; Pharmacokinetics; Elderly; Age; Comparative study