Steady-State Pharmacokinetics of Once-Daily Cyclobenzaprine Extended Release: A Randomized, Double-Blind, 2-Period Crossover Study in Healthy Volunteers

• Published in: Clinical therapeutics Vol. 33; no. 6; pp. 746 - 753
• Main Authors: Darwish, Mona, Hellriegel, Edward T.
• Format: Journal Article
• Language: English
• Published: Bridgewater, NJ EM Inc USA 01.06.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Amitriptyline - administration & dosage; Amitriptyline - adverse effects; Amitriptyline - analogs & derivatives; Amitriptyline - pharmacokinetics; Antidepressive Agents, Tricyclic - administration & dosage; Antidepressive Agents, Tricyclic - adverse effects; Antidepressive Agents, Tricyclic - pharmacokinetics; Area Under Curve; Biological and medical sciences; Catheters; Cross-Over Studies; cyclobenzaprine; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Drug dosages; Drug therapy; Female; Half-Life; Hepatitis; Humans; Internal Medicine; Male; Medical Education; Medical sciences; Middle Aged; muscle spasm; once daily; pharmacokinetic profile; Pharmacology. Drug treatments; Plasma; skeletal muscle relaxant; steady state; Studies; Young Adult; steady state; muscle spasm; once daily; pharmacokinetic profile; skeletal muscle relaxant; cyclobenzaprine; Human; Healthy subject; Controlled release form; Muscle relaxant; Psychotropic; Tricyclic compound; Striated muscle; Crossover study; Randomization; Dosage form; Cyclobenzaprine; Double blind study; Spasm; Antidepressant agent; Single daily dose; Daily dose; Pharmacokinetics
• ISSN: 0149-2918; 1879-114X; 1879-114X
• DOI: 10.1016/j.clinthera.2011.05.045

The single-dose pharmacokinetic profile of cyclobenzaprine extended-release (CER) has been previously characterized and compared with the pharmacokinetics of cyclobenzaprine immediate-release (CIR) administered 3 times daily for 3 doses. The objective of this study was to characterize the multiple-d...